Tag: PIM

Formononetin | FGFR2 inhibitor | Axon 4067

All All Products Enzymes Receptors Ion Channels Research Areas Oxidoreductases Transferases Lyases Isomerases Ligases Nuclear Receptors Ligand-gated ATP-Sensitive Angiogenesis Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics Immunology Miscellaneous Pain & Inflammation Stem Cell Oxidases MAO Cys-loop, cationic Cis-Trans Isomerase CypA DNA Topoisomerase Synthetases…

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Bioinformatics analysis of immune characteristics in tumors with alternative carcinogenesis pathways induced by human papillomaviruses | Virology Journal

de Martel C, Georges D, Bray F, Ferlay J, Clifford GM. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health. 2020;8:e180–90. Article  PubMed  Google Scholar  McKaig RG, Baric RS, Olshan AF. Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head…

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Ryvu Therapeutics Reports Third Quarter 2023 Financial

The total operating revenues amounted to $11.9M and increased by 42% compared to Q3 2022. Updated data from Phase Ib study of RVU120 in AML/HR-MDS to be presented at the upcoming American Society of Hematology (ASH) Annual Meeting in December. Preparations for executing Phase II clinical trials of RVU120 in…

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How to enrich product data with generative AI using Vertex AI

Product Information Management (PIM) is a critical process in the retail industry to manage product data, such as descriptions, images, and other attributes. In this blog post, we will show how to use Large Language Models (LLMs) with Vertex AI to enrich product data, which can improve the customer experience…

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Ryvu Therapeutics’ Global Licensee Menarini to Expand Development of MEN1703 (SEL24) with a New Study in Advanced Diffuse Large B-Cell Lymphoma (DLBCL)

–  Phase II Study to be Initiated in H1 2024 KRAKÓW, Poland , Sept. 14, 2023 /PRNewswire/ — Ryvu Therapeutics (WSE: RVU), a clinical-stage drug discovery and development company focusing on novel small molecule therapies that address emerging targets in oncology, today announced that Ryvu’s licensee, the Menarini Group, will…

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targeting PIM kinase to treat autoimmune disorders

A healthy immune system is supposed to defend the body against disease and infection, but in autoimmune diseases, the immune system malfunctions, and instead attacks the body’s healthy cells, tissues, and organs. Despite recent progress in therapeutic options for autoimmune disorders, a significant unmet need remains, which is why Mysthera…

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Weston Town Hall Happenings For August 4

**News Release Submitted by Town of Weston** August 4, 2023 Greetings and welcome to today’s Town Hall Happenings Opening NoteThis week marks the completion of my second year as your First Selectwoman and I am so grateful to serve this town that I love so much. Plenty has happened over…

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UCSD Professor Leads COVID-19, Recommendation System Research Using ‘Hyperdimensional Computing’ – High-Performance Computing News Analysis

Professor Tajana Simunic Rosing Intel Labs has released a case study involving a professor at the University of California-San Diego, who for the past five years has led research efforts into what’s called hyperdimensional computing aimed at solving memory and data storage challenges. Hyperdimensional computing (HD) is a type of…

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Combination Therapies May Spur Evolution of the Myelofibrosis Treatment Paradigm

JAK inhibitor combination therapies may bolster the efficacy of ruxolitinib (Jakafi) monotherapy in patients with myelofibrosis, although further phase 3 research is necessary to define the roles of these combinations and determine how certain patient subsets may benefit from these and other treatment approaches, according to Prithviraj Bose, MD. The…

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Role of RNA splicing mutation

Introduction Non-Hodgkin lymphoma is a heterogeneous group of cancers that starts during immune system differentiation.1 Recent reports show that more than 100 different lymphoma types have been identified.2 These lymphomas originate from cells of the immune system such as B cells, T cells, and dendritic cells. B-cell lymphomas are another…

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From past to present: opportunities and trends in the molecular detection and diagnosis of Strongyloides stercoralis | Parasites & Vectors

Bisoffi Z, Buonfrate D, Montresor A, Requena-Méndez A, Muñoz J, Krolewiecki AJ, et al. Strongyloides stercoralis: a plea for action. PLoS Negl Trop Dis. 2013;7:5. Google Scholar  Schär F, Trostdorf U, Giardina F, Khieu V, Muth S, Marti H, et al. Strongyloides stercoralis: global distribution and risk factors. PLoS Negl…

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Gromacs Installation Issue – AMD Community

Dear Community,   This is Pim, a new EPYC user. I just DIYed a workstation as following:     – Supermicro H11DSi     – EPYC 7B12 * 2     – Samsung RECC 3200 32G * 16     –  Samsung 980 Pro 2t     – Centos 7…

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Role and mechanism of PIM family in the immune microenvironment of diffuse large B cell lymphoma | World Journal of Surgical Oncology

DLBCL patients with high expression of PIM kinase family had a poor prognosis The prognostic value of PIM kinase family for DLBCL was verified with the dataset GSE10846. It was found that DLBCL patients with high expression of PIM1, PIM2, and PIM3 all had a poor OS (Fig. 1A–C). The results…

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Master mitotic kinases regulate viral genome delivery during papillomavirus cell entry

Marsh, M. & Helenius, A. Virus entry: open sesame. Cell 124, 729–740 (2006). Article  CAS  Google Scholar  Roe, T., Reynolds, T. C., Yu, G. & Brown, P. O. Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12, 2099–2108 (1993). Article  CAS  Google Scholar  Bieniasz, P. D., Weiss,…

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Gene Set – TFDP2

Symbol Name ACBD6 acyl-CoA binding domain containing 6 ACO2 aconitase 2, mitochondrial ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 AK2 adenylate kinase 2 ALDH6A1 aldehyde dehydrogenase 6 family, member A1 AP1S1 adaptor-related protein complex 1, sigma 1 subunit AP4M1 adaptor-related protein complex 4, mu 1 subunit APH1A APH1A…

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Percent identity matrix from ClustalOmega/Clustalw with Biopython

I have a set of sequences for the YPR193C coding sequence from various yeast strains. I would like to get the percent identity matrix from multiple sequence alignments using ClustalW, Clustal Omega, or MUSCLE using the Biopython wrappers. This should be possible for ClustalW and Clustal Omega based on the…

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