Tag: R

Protocol for single-nucleus ATAC sequencing and bioinformatic analysis in frozen human brain tissue.

Abstract Single-nucleus ATAC sequencing (snATAC-seq) employs a hyperactive Tn5 transposase to gain precise information about the cis-regulatory elements in specific cell types. However, the standard protocol of snATAC-seq is not optimized for all tissues, including the brain. Here, we present a modified protocol for single-nuclei isolation from postmortem frozen human…

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ggplot2 – Issue in creating polygon in ggplot in R

Why does my polygon look like two triangles instead of a box? Can some help explain how I can turn the polygon into a box? data <- structure(list(AREA = c(“a”, “a”, “b”, “b”), Lat = c(43.68389835, 43.68389835, 44.3395883, 44.3395883), Long = c(-88.22909367, -88.99888743, -88.22909367, -88.99888743)), row.names = c(NA, -4L), spec…

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r – How to plot in time series with ggplot, geom_line, with line group by ‘answer’

I have plotted this time series data that contains three variables: date, answer, and counts. I would like to plot in time series where the lines representing categories of the answers. I have tried this codes below, but result are not as expected: I did’t get any line. Could anyone…

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Unsure how to run FastQC on interactive node : bioinformatics

Hi all. My goal has long been to get involved in biology-problems — especially in the biomedical realm, but I haven’t had a direct path to doing so because I don’t love “doing” biology itself. For instance, I did a BS and MS in applied math with a healthy dose…

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Brawl breaks out outside ‘Squad’ congresswomen rally

Two protestors at an event at the Somerville Theatre featuring the progressive ‘squad’ congresswomen were involved in a brawl Saturday afternoon with four other men. One video of the incident shows four men approach the protestors, identified as Richard Cadigan-McCarron and Shawn Nelson, just after 4 p.m. and the camera…

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An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

We constructed an untargeted metabolomic workflow that integrated XY-Meta and metaX together. In this protocol, we displayed how to use XY-Meta to generate a decoy spectral library from open access spectra reference, and then performed FDR control and used the metaX to quantitate the metabolites after identifying the metabolomics spectra….

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Genetic footprints of assortative mating in the Japanese population

Study cohort description We used data on a total of 172,270 individuals of Japanese and East Asian ancestry. Of these, data on 165,098 individuals were obtained from BBJ, which has enrolled ≥200,000 participants to date. BBJ is a multi-institutional hospital-based genome cohort that collected participants affected with at least one…

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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Martincorena, I. et al. Somatic mutant clones colonize the human esophagus with age. Science 362, 911–917 (2018). CAS  PubMed  PubMed Central  Google Scholar  Yizhak, K. et al. RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. Science 364, eaaw0726 (2019). CAS  PubMed  PubMed Central  Google Scholar  Yokoyama, A….

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Plastomes of limestone karst gesneriad genera Petrocodon and Primulina, and the comparative plastid phylogenomics of Gesneriaceae

Features of the newly sequenced Petrocodon and Primulina plastomes Sizes of the nine newly sequenced plastomes of Petrocodon and Primulina range from 152,323 bp in Pr. medica (D.Fang ex W.T.Wang) Yin Z.Wang to 153,786 bp in Pr. cordata Mich.Möller & A.Weber (Tables 1, S1). These nine plastomes display the typical quadripartite structure…

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Ten challenges for clinical translation in psychiatric genetics

Pardinas, A. F. et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat. Genet. 50, 381–389 (2018). CAS  PubMed  PubMed Central  Article  Google Scholar  Stahl, E. A. et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat. Genet. 51,…

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HISAT2 and HTSEQ command

HISAT2 and HTSEQ command 0 @4fedfa78 Last seen 10 hours ago Japan Hello, For analysis of the data by rna-sequencing I selected HISAT2 and HTSeq-count for mapping and counting the genes levels, the libraryLayout is paired, I am using the below command for both but the results are not exact…

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Electrochemistry Analysis of Drugs Summarized in Lenvatinibdextrins

Therefore, these systems generally have to have a advanced level involving computational sources as well as run-time, which usually boosts as the difficulty along with the size the information sets. It is known that computational charges are mainly due to continuing assessment technique of the guidelines and also the men…

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r – Feature Standardize in AutoML H2O

I’m wondering how to standardize features when using h2o‘s AutoML with deep learning and GLM algorithms. Seems it is supported to deep learning and GLM models (docs.h2o.ai/h2o/latest-stable/h2o-docs/data-science/algo-params/standardize.html), but in h2o.automl it does not accept the standardize = TRUE argument. My questions are: Does autoML automatically scales (i.e. standardizes) the features…

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Bioconductor – SNPlocs.Hsapiens.dbSNP155.GRCh37 (development version)

DOI: 10.18129/B9.bioc.SNPlocs.Hsapiens.dbSNP155.GRCh37     This is the development version of SNPlocs.Hsapiens.dbSNP155.GRCh37; to use it, please install the devel version of Bioconductor. Human SNP locations and alleles extracted from dbSNP Build 155 and placed on the GRCh37/hg19 assembly Bioconductor version: Development (3.16) The 929,496,192 SNPs in this package were extracted from…

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Multiple conditions DESeq2

Multiple conditions DESeq2 1 Hi, I am working on differentially expressed genes analysis of RNA-seq data extracted from multiple but related experiments: experiment DESH21_E DESH40_S DESN21_E DESN21_S DESN40_E DESN40_S ES21_E ES21_S ES40_E ES40_S where, DES and ES are different in vitro cells; 21/40 are concentration (low/high), and H/N are additional…

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Visualization of Pool-HMM results

Visualization of Pool-HMM results 0 Hello everyone, I have run the Pool-HMM tool on my pool-seq data and got final results in this format Chr Start End Pool-HMM 1 312212 413291 11.60071199 1 595314 676207 11.40558651 1 3136358 3180593 11.65338609 1 3788166 3813896 4.561544648 1 5202297 5218014 1.620942559 1 5448808…

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Immuno Cure BioTech acquires Shanghai Teresa Healthcare | Taiwan News

Integrating Electroporation Technology & DNA Vaccine Platforms HONG KONG SAR – Media OutReach – 20 September 2022 – Immuno Cure BioTech, a clinical stage biotechnology group based in the Hong Kong Science Park specialising in DNA vaccines and immunotherapies, announced today the acquisition of 92.6% of Shanghai Teresa Healthcare, the…

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Senior/Junior Postdoctoral fellow in Bioinformatics

Highly motivated candidates are invited to apply for a 2-year postdoctoral position (with the possibility of an extension) in the laboratory of Assoc. Professor David Gomez-Cabrero in the Biological and Environmental Sciences and Engineering (BESE) Division at the King Abdullah University of Science and Technology (KAUST) (www.kaust.edu.sa/en/study/faculty/david-gomez-cabrero). The project investigates…

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Job – Principal Biostistician/Bioinformatics job at Kenya Medical Research

Vacancy title: Principal Biostistician/Bioinformatics [ Type: FULL TIME , Industry: Research , Category: Research ] Jobs at: Kenya Medical Research – KEMRI Deadline of this Job: 06 October 2022   Duty Station: Within Kenya , Kisumu , East Africa SummaryDate Posted: Tuesday, September 20, 2022 , Base Salary: Not Disclosed…

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Institut Pasteur de Dakar hiring Bioinformatics Analyst in Dakar, Senegal

We are looking for an enthusiastic and motivated bioinformatician to join the Epidemiology, Clinical Research, and Data Science department at the Institut Pasteur de Dakar. The selected candidate will develop and apply bioinformatics methods to support multiple projects in the area of next-generation sequencing and -omics. Minimum qualification Bachelor’s degree…

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DE analysis with multiple factors

DE analysis with multiple factors 0 Hi all, I’m using DEP R package to perform analysis (including DE analysis) on proteins across different conditions bioconductor.org/packages/devel/bioc/vignettes/DEP/inst/doc/DEP.html The package uses limma for DE analysis My experiment is structured as : sample – disease_state( disease / healthy) – environment (env1 / env2) I…

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Electroporation Protocol Bio Rad Gene Pulser

Unit will be tested before shipping. Rad Gene Pulser different transformations. We autoclave the Freezing Mix and store at room temperature. No limit on the number of engaged members from Commun. It is not necessary to incubate DNA with cells. We have a large inventory of equipment, components and parts…

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Scientist* Bioinformatics & Statistics | datacareer.de

Mainz Work experience Research, development, teaching Become a member of the BioNTech Family! As a part of our team of more than 2.500 pioneers, you will play a key role in developing solutions for some of the most crucial scientific challenges of our age. Within less than a year, we…

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KEGG COMPOUND: C00236

KEGG COMPOUND: C00236     COMPOUND: C00236 Help Entry C00236                      Compound                                Name 3-Phospho-D-glyceroyl phosphate;1,3-Bisphospho-D-glycerate;(R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydride with phosphoric propanoic acid;D-Glycerate 1,3-diphosphate Formula C3H8O10P2 Exact mass 265.9593 Mol weight 266.0371 Structure Mol fileKCF fileDB search Reaction Pathway map00010   Glycolysis / Gluconeogenesis map00710   Carbon fixation in photosynthetic organisms map01060   Biosynthesis of plant secondary metabolites map01061   Biosynthesis…

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Set Axis Breaks Of Ggplot2 Plot In R 3 Examples Specify Tick Marks Of Graph Scale X Con Code

Set Axis Limits in ggplot2 R Plot (3 Examples) | Adjust … 5 days ago Modification of Axis Limits with scale_x_continuous. We have basically two alternatives, if … Modification of Axis Limits with coord_cartesian. Another way to widen the axis ranges of … Cutting off Values with Zoom In. In…

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[100% Discount] Image Recognition for Beginners using CNN in R Studio

You’re looking for a complete Convolutional Neural Network (CNN) course that teaches you everything you need to create an Image Recognition model in R, right? You’ve found the right Convolutional Neural Networks course! After completing this course you will be able to: Identify the Image Recognition problems which can be solved using CNN Models….

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Dyadic International : Presentation | MarketScreener

Dyadic International (NASDAQ: DYAI) Next Generation Proteins for World Health C1 Vaccine Technology Presentation Mark Emalfarb, Founder & CEO Vaccine Technology Summit September 15-16, 2022 London UK Safe Harbor Regarding Forward-looking Statements Certain statements contained in this presentation are forward-looking statements within…

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Hidden paths to endless forms most wonderful: ecology latently shapes evolution of multicellular development in predatory bacteria

Carroll, S. B. Endless Forms Most Beautiful: The New Science of Evo Devo and the Making of the Animal Kingdom (Quercus, 2005). Dobzhansky, T. & Spassky, B. Genetics of natural populations. XI. Manifestation of genetic variants in Drosophila pseudoobscura in different environments. Genetics 29, 270–290 (1944). CAS  PubMed  PubMed Central …

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Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes.

Author List Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Kasahara NA, Cicciarelli JC Publication ID (Profile URL) researcherprofiles.org/profile/27465210 Publication Title Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke…

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Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

doi: 10.1038/s41556-022-00989-7. Online ahead of print. Brandon T Wesley #  1   2 , Alexander D B Ross #  1   2   3 , Daniele Muraro  1   2   4 , Zhichao Miao  4   5 , Sarah Saxton  6   7 , Rute A Tomaz  1   2 , Carola M Morell  1   2…

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All transcript variants in gene MAD1L1 – BIPMed SNP Array

Legend Please note that a short description of a certain column can be displayed when you move your mouse cursor over the column’s header and hold it still. Below, a more detailed description is shown per column. Effect: The variant’s effect on the protein’s function, in the format ‘R/C’ where…

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Research Fellow, Bioinformatician – Cancer Science Institute job with NATIONAL UNIVERSITY OF SINGAPORE

Job Description A postdoctoral position is available immediately in Prof Chng Wee Joo’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of the lab is on deciphering transcriptional and genomic abnormalities in the context of blood cancer, including epigenetic and superenhancer deregulation, using single cell…

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JNCASR Nomination for Ramanujan/Ramalingaswami Fellowship

JNCASR Nomination for Ramanujan/Ramalingaswami Fellowship Nomination for Ramanujan/Ramalingaswami Fellowship. Nomination for Ramanujan/Ramalingaswami Fellowship 2022 at JNCASR. Interested and eligible applicants can check out all of the details on the same below This call expires in 29Days 11Hours 57Minutes 35Seconds Nomination for Ramanujan/Ramalingaswami Fellowship Jawaharlal Nehru Centre for Advanced Scientific Research…

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Bioinformatics Intern Job Des Moines IA

Corteva Agriscience is seeking two highly capable and motivated 3 month interns to develop and deploy computational biology solutions by leveraging their knowledge of best practices to solve meaningful challenges in the areas of bioinformatics and computational biology using high performance computing.  As part of our R&D data science…

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Service Procurement Market Growth Challenges (2022-2028)

“ The global Service Procurement market is being driven by a surge in demand for precise technology, as well as rising government steps to promote efficient procedures that raise productivity and benefit industrial players. The introduction of rules controlling the use of new technology such as drones and AI, on…

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r – Adding values as text in raster images – ggplot2

I am plotting values in SpeedClass as rasterfile. I want to add text to the each tile to show the AvgSpeed from column 3. enter image description here Here is my code so far: AllDataSBAvgSpeed <- aggregate(AllDataSB$speed ~ AllDataSB$milepost + AllDataSB$Time, data = AllDataSB, mean) colnames(AllDataSBAvgSpeed)[1] <- “milepost” colnames(AllDataSBAvgSpeed)[2] <-…

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ggplot2 – How to plot several outcomes for several groups in R ggplot?

I want to build a single graph displaying several outcomes (with different point- and lineshapes for each, respectively) for several strata (displayed in different colours) over time. Using this for one group works: data <- data.frame( time = rep(c(“Baseline”, “Follow-Up 1”, “Follow-Up 2”), each = 8), stratum = rep(c(“Intervention”, “Control”),…

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Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious

Introduction Infection due to myelosuppression after chemotherapy for malignancies is a common complication and cause of treatment-related death.1,2 In clinical practice, the traditional identification of pathogens relies heavily on laboratory capacity to detect common pathogenic microorganisms with discrete methods, such as assays for pathogen-specific antibodies, nucleic acids and antigens, and…

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FBXW7 and Its Downstream NOTCH Pathway Could be Potential Indicators of Organ-Free Metastasis in Colorectal Cancer

doi: 10.3389/fonc.2021.783564. eCollection 2021. Dongzheng Li  1 , Shiye Jiang  1 , Xin Zhou  1 , Chengshuai Si  1 , Peng Shao  1 , Qian Jiang  1 , Liuqing Zhu  2 , Lu Shen  2 , Qi Meng  2 , Jiani C Yin  2 , Yang Shao  2   3 , Yueming Sun  4 , Liu Yang  1 Affiliations Expand Affiliations 1…

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A global dataset of microbial community in ticks from metagenome study

Data collection The study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement20. To attain an exhaustive review of the published literature on the microbiome diversity by NGS in field-collected ticks, a literature search was conducted on Chinese and English databases using a set…

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PRIME PubMed | Genetic evidence for a single stock of the deep-sea teleost Beryx decadactylus in the North Atlantic Ocean as inferred from mtDNA control region analysis

Citation Friess, C, and G R. Sedberry. “Genetic Evidence for a Single Stock of the Deep-sea Teleost Beryx Decadactylus in the North Atlantic Ocean as Inferred From mtDNA Control Region Analysis.” Journal of Fish Biology, vol. 78, no. 2, 2011, pp. 466-78. Friess C, Sedberry GR. Genetic evidence for a…

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Online Diagram Editor Market to Get a New Boost

Advance Market Analytics added research publication document on Worldwide Online Diagram Editor Market breaking major business segments and highlighting wider level geographies to get deep dive analysis on market data. The study is a perfect balance bridging both qualitative and quantitative information of Worldwide Online Diagram Editor market. The study…

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24 groundbreaking events that happened during the Queen’s reign

When Queen Elizabeth was crowned in 1953, she promised to rule for her whole life. It was a commitment that never waivered and saw her on the throne for more than 70 years, over which time the world changed significantly. During her reign, the Queen saw some of the most…

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The crisprVerse: a comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies

Abstract The success of CRISPR-mediated gene perturbation studies is highly dependent on the quality of gRNAs, and several tools have been developed to enable optimal gRNA design. However, these tools are not all adaptable to the latest CRISPR modalities or nucleases, nor do they offer comprehensive annotation methods for advanced…

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deseq2 – Creating multiple phenotype datasets using bootstrap method “Bootstrap-samples-by-column-of-a-data-frame-in-r” for DEG analysis

I am working on a datasets and after some discussion with my group, we doubt that maybe one or more of our controls are different than the other controls. The motivation is to see if one or more controls have been effected differently by the solvent they were kept in….

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Bioinformatics Scientist in Pittsburgh, PA

Description Purpose:The scientist works independently using a robust math toolbox to discover solutions for a diverse portfolio of interesting and challenging problems. The scientist develops, implements, and monitors advanced analytic, medical informatics, and predictive modeling tools for health care programs at the UPMC. The scientist normally works Monday through Friday…

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Bioinformatics phd Jobs in India, September 2022

3.8 Senior Manager -Bioinformatics Bangalore ₹350,000 – ₹627,807 (Glassdoor Est.) Understand complex research problems and design and implement bioinformatics solutions working across multiple stakeholders and customers.… 4.2 Bioinformatics Trainer/ Research Associate Noida ₹160,000 – ₹340,000 (Employer Est.) Executing biotechnology training for students. Good Knowledge of Programming Languages. Good Knowledge of…

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Data Scientist – Bioinformatics at Faculty – London, England, United Kingdom

Faculty is one of Europe’s leading applied artificial intelligence companies. We build, deploy and operate AI solutions to increase our customers’ performance and help them realise their full potential. We believe that AI should be trustworthy, impactful and beneficial across society. Those principles have shaped our work with more than…

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Integrated Resources, Inc ( IRI ) hiring Bioinformatics Data Scientist in Mississauga, Ontario, Canada

Location: Mississauga, ON Duration: 12+ Months Who We Are Looking ForWe are looking for an experienced Bioinformatics Data Scientist, with a proven track record of generating insights and building predictive models from biological data.For this position, we will consider applicants focused on Data Science applied to biological data with 3…

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Global Gene Therapy R&D Market Worth US$ 22,685.70 million by 2031: Visiongain Reports Ltd

Visiongain Reports Ltd Global Gene Therapy R&D Market Forecast 2021-2031: – Market Segment by Disease {Cancer, Rare Diseases (Oncologic, Non-Oncologic), Cardiovascular Diseases, Ophthalmic Diseases, Hematology, Neurological, Diabetes Mellitus, Other Diseases}, Vector {Viral (Retrovirus, Adenovirus, AAV, Lentivirus, Others), Non-Viral (Naked DNA, Gene Gun, Electroporation, Lipofection)}, Techniques (Gene Augmentation Therapy, Gene Replacement…

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[Internship] Bioinformatics Intern, Fall 2022 at Harmonic Discovery (United States)

About Us Based in NYC, Harmonic Discovery is a biotechnology company leveraging biology, medicinal chemistry, and machine learning to create a new generation of therapeutics for oncology and autoimmune disorders. We look for passionate innovators, radical thinkers, and collaborative builders. It’s time to integrate our understanding of biology and chemistry…

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Exporting DESeq2 results to CSV files

Exporting DESeq2 results to CSV files 1 Hello there. I need a help with this situation. I’m following this vignette and I’m getting an error on the item “Exporting results to CSV files”: write.csv(as.data.frame(resOrdered), file=”condition_treated_results.csv”) In my case i get this: write.csv(as.data.frame(resOrdered), file = “myres_counts.csv”) error in evaluating the argument…

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TSE treatment of two dogs at FloridaWild veterinary hospital shows promising results

Scandinavian ChemoTech AB’s (publ) subsidiary Vetiqure AB has been notified that two dogs have recovered after being treated with its Tumour Specific Electroporation (TSE) treatment at the FloridaWild veterinary hospital. During the evaluation of vetIQure™ at FloridaWild, several treatments were carried out on dogs. After this evaluation was completed, the…

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Commercial software for genomics / NGS / bioinformatics

Forum:Commercial software for genomics / NGS / bioinformatics 2 Hi there, I’ve been doing bioinformatics and genomics for almost 10 years mainly using academic software, mostly with command-line interface, as well as writing my own scripts using Perl/python/R.Lately, I’ve run into three commercial tools related to bioinformatics and genomics, namely:…

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r – While running ggplot2 command, geom smooth is not working

This question was caused by a typo or a problem that can no longer be reproduced. While similar questions may be on-topic here, this one was resolved in a way less likely to help future readers. I am giving a small portion of my task…

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Adding objects together in R (like ggplot layers)

I’m doing OOP R and was wondering how to make it so the + can be used to add custom objects together. The most common example of this I’ve found is in ggplot2 w/ adding geoms together. I read through the ggplot2 source code and found this github.com/hadley/ggplot2/blob/master/R/plot-construction.r It looks…

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plm – Error with indexing pdata.frame in r using pgmm()

I am a student and struggling with a specific problem regarding the pgmm() function of the plm package in R. I have a pdata.frame for which I want to use the pgmm function for a dynamic panel model. However, the following error occurs: Error in pdata.frame(data, index): variable NA does…

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The genus Serratia revisited by genomics

Merlino, C. P. Bartolomeo Bizio’s letter to the most eminent priest, Angelo Bellani, concerning the phenomenon of the red-colored polenta [translated from the Italian]. J. Bacteriol. 9, 527–543 (1924). Grimont, P. A. D. & Dulong de Rosnay, H. L. C. Numerical study of 60 strains of Serratia. J. Gen. Microbiol….

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Improved Genome Editing by an Engineered CRISPR-Cas12a

%PDF-1.4 % 166 0 obj > endobj 182 0 obj >stream 2022-09-02T18:05:42Z Word 2022-09-03T22:12:57-07:00 2022-09-03T22:12:57-07:00 macOS Version 12.5 (Build 21G72) Quartz PDFContext application/pdf Improved Genome Editing by an Engineered CRISPR-Cas12a uuid:c71e5867-1dd1-11b2-0a00-3508276d7200 uuid:c71e586a-1dd1-11b2-0a00-b80000000000 endstream endobj 5 0 obj > endobj 2 0 obj > endobj 58 0 obj > endobj 89 0…

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Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification

doi: 10.1002/kjm2.12574. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China. Item in Clipboard Yi Yu et al. Kaohsiung J Med Sci. 2022. Show…

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A7993 – YFull YTree Info

R-A7993 – YFull YTree Info SNPs currently defining R-A7993 A7993     Sample ID Country / Language Info Ref File Testing company Statistics Status YF063745 —— R-A7993 R-A7993*, R-FGC59783* Hg38 .BAM FTDNA (Y700) 30X, 18.6 Mbp, 151 bp YF015291 Germany (Rheinland-Pfalz) R-A7993 R-A7993*, R-FGC59783* Hg38 .BAM FTDNA (Y500) 28X, 12.1 Mbp,…

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GPU inference doesn’t work when importing open3d

Thanks for your error report and we appreciate it a lot. Checklist I have searched related issues but cannot get the expected help. I have read the FAQ documentation but cannot get the expected help. The bug has not been fixed in the latest version. Describe the bug The GPU…

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Did Stacey Dash bleach her skin? Here are before and after photos after what looks like skin lightening

Did Stacey Dash bleach her skin? Here are before and after photos after what looks like skin lightening Hello Everyone lastest Update about Did Stacey Dash bleach her skin? Here are before and after photos after what looks like skin lightening Welcome guys to Bulletinzone.com . Here you can Find…

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Cellosaurus cell line LL/2 (LLC1) (CVCL_4358)

STR profile Source(s): PubMed=31220119 Markers: Mouse STR 1-1 15,17,18 Mouse STR 1-2 18,19,20 Mouse STR 2-1 15,16 Mouse STR 3-2 13,14 Mouse STR 4-2 20.3,21.3,23.3 Mouse STR 5-5 16,17,18 Mouse STR 6-4 17,18 Mouse STR 6-7 14,15,16 Mouse STR 7-1 26.2,27.2,28.2 Mouse STR 8-1 16 Mouse STR 11-2 13.3,14.3,15.3,16 Mouse…

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Cas4-Cas1 is a Protospacer Adjacent Motif-Processing factor mediating half-site spacer integration 5 during CRISPR adaptation

@article{271b49f1d0724db19d00b53dbf126380, title = “Cas4-Cas1 is a Protospacer Adjacent Motif-Processing factor mediating half-site spacer integration 5 during CRISPR adaptation”, abstract = “The immunization of bacteria and archaea against invading viruses via CRISPR adaptation is critically reliant on the efficient capture, accurate processing, and integration of CRISPR spacers into the host genome….

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Evolution of stickleback spines through independent cis-regulatory changes at HOXDB

Darwin, C. On the Origin of Species by Means of Natural Selection (John Murray, 1859). Owen, R. On the Archetype and Homologies of the Vertebrate Skeleton (Richard and John E. Taylor, 1848). Stern, D. L. & Orgogozo, V. Is genetic evolution predictable? Science 323, 746–751 (2009). CAS  PubMed  PubMed Central …

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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017). CAS  PubMed  PubMed Central  Article  Google Scholar  Hekselman, I. & Yeger-Lotem, E. Mechanisms of tissue and cell-type specificity in heritable traits and diseases. Nat. Rev. Genet. 21, 137–150 (2020)….

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How can I convert Ensembl ID to gene symbol in R?

I tried several R packages (mygene, org.Hs.eg.db, biomaRt, EnsDb.Hsapiens.v79) to convert Ensembl.gene to gene.symbol, and found that the EnsDb.Hsapiens.v79 package / gene database provides the best conversion quality (in terms of being able to convert most of Ensembl.gene to gene.symbol). Install the package if you have not installed by running…

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Cellosaurus cell line LoVo (CVCL_0399)

Publications PubMed=1260746Drewinko B., Romsdahl M.M., Yang L.Y., Ahearn M.J., Trujillo J.M.Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.Cancer Res. 36:467-475(1976) PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0Chen T.-R., Hay R.J., Macy M.L.Karyotype consistency in human colorectal carcinoma cell lines established in vitro.Cancer Genet. Cytogenet. 6:93-117(1982) PubMed=3335022Alley M.C., Scudiero D.A., Monks A., Hursey M.L.,…

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Chimeric antigen receptor T cell therapy for cancer: clinical applications and practical considerations

Joseph E Maakaron, assistant professor of medicine, Marie Hu, assistant professor of medicine, Najla El Jurdi, assistant professor of medicine University of Minnesota Twin Cities, Minneapolis, United States Correspondence to: maaka001{at}umn.edu Abstract Chimeric antigen receptor T cells have revolutionized the treatment of hematological malignancies during the past five years, boasting…

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The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering

Retrosynthesis from target to chassis Typically, the target compound, also named “source compound” is the compound of interest one wishes to produce, while the precursors are usually compounds that are natively present in a chassis strain. In the present implementation, the target can be any chemical that could be described…

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r – How can I install the Bioconductor package “liftOver” in a conda environment?

I’m trying to install the Bioconductor package liftOver using conda. I’m creating a conda environment using a .yml file like this: conda env create -f coo_environment.yml When I do this, I get: Collecting package metadata: done Solving environment: failed ResolvePackageNotFound: – bioconductor-liftover The relevant contents of coo_environment.yml are shown below…

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Log2FC values slightly higher in some genes after DESeq2 shrinkage

Hi, I have a question about DESeq2 LFCshrinkage: Is it possible that some genes have a slightly higher LFC after shrinkage? It happened during my RNAseq DE analysis, I have very deeply sequenced samples with large base means. I tried visualizing using MAplot check, and it looks fine. I’m mainly…

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Research Fellow to monitor SARS-CoV-2 and other viral pathogens in samples, School of Biological Sciences at Queen’s University Belfast, UK

Application closing date: 05/09/2022 Job reference: 22/110138 The School of Biological Sciences at Queen’s University Belfast, is currently seeking to appoint an exceptional candidate to the post of Research Fellow. The successful candidate will be an active member of a research team monitoring SARS-CoV-2 and other viral pathogens in samples…

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Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3

In vitro reconstitution of Escherichia coli CRISPR-Cas3 interference E. coli CRISPR-Cas3 is generally well-characterized type I CRISPR complexes in vitro and in vivo32,33,37,38. However, recombinant EcoCas3 protein is difficult to purify because of poor solubility and propensity to aggregate at 37 °C25,26,30,39. Co-expression of HtpG chaperon40 and/or low temperature growth at…

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r – How can I change the order of stacking in ggplot2 stacked bar chart?

I’m trying to create a stacked bar chart, but I’ve run into an issue where ggplot2 automatically stacks the values in my chart based on magnitude rather than keeping the stack order the same between bars. Dataset: drive.google.com/file/d/1lriQafJRtGrNC6OD2FnHx9Rt-BT9ReVm/view?usp=sharing Code: library(viridis) library(ggplot2) ggplot(rank_df, aes(y = Rank, x = Kinase, fill =…

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r – ggplot – geom_raster scale_fill_identity

I’m kinda stuck in a matter. Following the advice of another fellow user in this platform, I was able to plot a raster image and have the pixel assume the values I had assigned I a column, named “colors” in my df. That was great, but know I need the…

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Installation | _main.knit

Before you start the installation of R, make sure your computer software is up-to-date. To get the most out of R, it is usually best to update to the maximum possible operating system. On a Mac, under the  you can find About This Mac. Then, in the Overview Tab…

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Introduction to HybridNets using PyTorch

In deep learning and computer vision, models tackle a specific task. For example, we can find models for image classification, object detection, and image segmentation also. But there are very few models out there which perform end-to-end vision perception on both, object detection and semantic segmentation. But one of the…

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NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis

NDX is a heterochromatin-associated factor To understand the genome-wide regulatory roles of NDX, we first analyzed its genomic distribution. For this, we performed chromatin immunoprecipitation sequencing (ChIP-seq) in 10-day old Arabidopsis seedlings expressing N-terminally and C-terminally tagged NDX fusion proteins (flag-NDX/ndx1-1(FRI)/flc-2 and NDX-GFP/ndx1-1(FRI)/flc-2, respectively) expressed from their endogenous promoter21,32. The…

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CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS IN PRIMARY BREAST DIFFUSE LARGE B-CELL LYMPHOMA

Keywords Diffuse large B-cell lymphoma, Breast, Prognostic factors, Relapse, Central nervous system References [1] C. Wiseman, and K.T. Liao, Primary lymphoma of the breast. Cancer 29 (1972) 1705-12.www.ncbi.nlm.nih.gov/pubmed/4555557 [2] P.J. Hosein, J.C. Maragulia, M.P. Salzberg, O.W. Press, T.M. Habermann, J.M. Vose, M. Bast, R.H. Advani, R. Tibshirani, A.M. Evens, N….

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Simultaneously induced mutations in eIF4E genes by CRISPR/Cas9 enhance PVY resistance in tobacco

Pasin, F., Daròs, J.-A. & Tzanetakis, I. E. Proteome expansion in the Potyviridae evolutionary radiation. FEMS Microbiol. Rev. 46, 011. doi.org/10.1093/femsre/fuac011 (2022). Article  Google Scholar  Karasev, A. V. & Gray, S. M. Continuous and emerging challenges of Potato virus Y in potato. Annu. Rev. Phytopathol. 51, 571–586 (2013). CAS  PubMed …

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Differential enrichment of H3K9me3 in intrahepatic cholangiocarcinoma | BMC Medical Genomics

Sia D, Tovar V, Moeini A, Llovet JM. Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies. Oncogene. 2013;32(41):4861–70. CAS  Article  Google Scholar  Sungwan P, Lert-Itthiporn W, Silsirivanit A, Klinhom-On N, Okada S, Wongkham S, Seubwai W. Bioinformatics analysis identified CDC20 as a potential drug target for cholangiocarcinoma. PeerJ. 2021;9:e11067. Article …

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Unveiling new perspective of phylogeography, genetic diversity, and population dynamics of Southeast Asian and Pacific chickens

Food and Agriculture Organization. The state of the world’s animal genetic resources for food and agriculture (Rome, 2007). Lawler, A. Dawn of the chicken revealed in Southeast Asia. Science 368, 1411 (2020). ADS  CAS  PubMed  Article  Google Scholar  Sykes, N. A social perspective on the introduction of exotic animals: the…

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DNA Methylation Sequencing market to showcase strong CAGR between 2028 and 2028

The business intelligence report on the DNA Methylation Sequencing market provides investors a tactical advantage by focusing on the growth trajectory of this business vertical during 2022–2028 through a thorough assessment of the historical and current trends. The estimations in the document have also been calculated and verified by professionals…

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Bioconductor – lumi

DOI: 10.18129/B9.bioc.lumi     This package is for version 3.12 of Bioconductor; for the stable, up-to-date release version, see lumi. BeadArray Specific Methods for Illumina Methylation and Expression Microarrays Bioconductor version: 3.12 The lumi package provides an integrated solution for the Illumina microarray data analysis. It includes functions of Illumina…

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Research Fellow, Bioinformatician, Department of Medicine job with NATIONAL UNIVERSITY OF SINGAPORE

Job Description To provide specialist bioinformatics analyses of genomic, transcriptomic, proteomic and cellular phenotypic data to investigate genetic influences on gene expression and vascular cell behaviour in relation to cardiovascular diseases. To provide input into the design of experimental studies and the preparation of research grants and scientific…

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Global Genome Editing Market Report 2022: Developing Biotechnology Industry in Emerging Regions Presents Opportunities – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Genome Editing Market Forecast to 2028 – COVID-19 Impact and Global Analysis By Technology, Application, and End User” report has been added to ResearchAndMarkets.com‘s offering. The genome editing market is projected to reach US$ 16,986.69 million by 2028 from US$ 5,199.40 million in 2021; it is expected to…

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How to Choose the Right Bioinformatics Position in 2022?

When you’re looking to land a good bioinformatics job, whether you’re a fresher, a career changer, or an experienced candidate, there’s usually a lot on your mind. And although the job search phase can look intimidating and exhausting, there has never been a better time to start a career in…

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Exponential curve fitting in Python matplotlib

Exponential curve fitting in Python matplotlib 0 Dear community, I’m trying to fit an exponential curve without overfitting. Currently, my code uses 3 to 5 parameters for fitting the curve which looks nice but that incurs information cost and overfitting. Could you help me solve this problem where I can…

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What is the Difference Between FASTA and FASTQ

The key difference between FASTA and FASTQ is that FASTA is a text-based format that only stores nucleotide or protein sequences, while FASTQ is a text-based format that stores both sequence and associated sequence quality values. Bioinformatics is a field that uses different software to analyse and understand biological data,…

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What is the ggplot2 package in R?

Overview The programming language R is popular among statisticians and mathematicians for mathematical computations and programming. The language has many diverse libraries that help make a user’s programming journey easy. It also has built-in datasets that can be used for experimenting and learning. The ggplot2 is one of R’s most…

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r – Plot 4-parameter logistic model with ggplot

I am trying to plot results from a 4 parameter logistic regression with ggplot. y= (q1) diversity measures for bird dataset, x = (FC600) Forest cover measures. data$q1 [1] 13.873635 13.377120 11.099290 11.481513 7.989731 [6] 9.750019 12.737163 12.971196 12.413030 11.576204 [11] 13.909131 14.801793 11.270471 11.126155 13.620503 [16] 11.092484 11.651279 11.304653…

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rstudio/tensorflow – bytemeta

TensorFlow for R TensorFlow™ is an open source software library for numerical computation using data flow graphs. Nodes in the graph represent mathematical operations, while the graph edges represent the multidimensional data arrays (tensors) communicated between them. The flexible architecture allows you to deploy computation to one or more CPUs…

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iPSCs derived from infertile men carrying complex genetic abnormalities can generate primordial germ-like cells

Patients and controls The patient 1 was 38 years old and consulted for infertility after he and his partner had been trying to conceive for 2 years. The patient was the first child of unrelated parents, and he had four brothers and five sisters whose fertility status could not be determined…

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Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US Usman A. Tahir, Daniel H. Katz, Jeremy M. Robbins, Zsu-Zsu Chen, Mark D. Benson, Daniel E. Cruz, Debby Ngo, Shuliang Deng, Xu Shi, Shuning Zheng, Aaron S. Eisman, Laurie Farrell, James G. Wilson & Robert E. Gerszten Broad Institute of Harvard and MIT, Cambridge, MA, US Julian Avila-Pachecho, Alexander G….

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Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

Study population The study sample included 34,072 unrelated (3rd degree or less) TOPMed participants from eight U.S. based cohort studies: Jackson Heart Study (JHS; n = 2504), Framingham Heart Study (FHS; n = 3520), Hispanic Community Health Study/Study of Latinos (HCHS/SOL; n = 6,408), Atherosclerosis Risk in Communities study (ARIC; n = 6197), Cardiovascular Health Study (CHS; n = 2835),…

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Loading reference genome from BSgenome

Loading reference genome from BSgenome 1 I am trying to run an analysis via the MutationalPatterns package. The first step is to install the BSgenome package, and then load a reference genome from BSgenome: library(“BSgenome”) ref_genome <- “BSgenome.Mmusculus.UCSC.mm39” library(ref_genome, character.only = TRUE) When I run my script, it gets hung…

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Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Chu, B. B. et al. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell 161, 291–306 (2015). CAS  Article  Google Scholar  Luo, J., Yang, H. & Song, B. L. Mechanisms and regulation of cholesterol homeostasis. Nat. Rev. Mol. Cell Biol. 21, 225–245 (2020). CAS  Article  Google Scholar  Luo, J., Jiang, L., Yang,…

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InnoCare Releases 2022 Mid-Year Results and Business Highlights

BEIJING–(BUSINESS WIRE)–InnoCare Pharma (HKEX: 09969), a leading biopharmaceutical company focusing on cancer and autoimmune diseases, today announced 2022 mid-year results which ended on June 30, 2022. Dr. Jasmine Cui, Co-founder, Chairwoman and CEO of InnoCare said: “The announcement of 2022 mid-year results coincides with our seventh anniversary. In the challenging…

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