Tag: R

Translational Regenerative Medicine market is estimated to grow at a CAGR of 24.3% by 2034: Visiongain

Visiongain Reports Ltd Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS…

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Scaling of MD with domain decomposition on JUWELS Cluster – Developers discussions

GROMACS version: 2024-dev-20240201-787d96c7a9-unknownGROMACS modification: YesI’m conducting some performance tests on the JUWELS Cluster, trying to see the improvement in performance that DD can bring within a single node. GROMACS build infoHere, GROMACS was built using GCC v11.4.0, uses OpenMP and OpenMPI v4.1.5, and builds its own FFTW v3.3.8. JUWELS Cluster…

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Bioinformatics Developer (Intermediate To Senior) in New Zealand

Job Details Auckland, Auckland, New Zealand Netvalue Ltd Posted 1 day ago Want updates for this and similar Jobs? This advertiser has chosen not to accept applicants from your region. Full Job Description Bioinformatics Developer (Intermediate to Senior) Bioinformatics Developer (Intermediate to Senior) 15 openings But enough about us, what…

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Translational Regenerative Medicine market is estimated to

Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS Analysis of Leading…

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Assessing the Durability, Tolerability of Loncastuximab in R/R DLBCL

CASE A 73-year-old woman presented with fever, headaches, and 7-lb unintentional weight loss​. Medical history: no family history of cancer, and hyperlipidemia that was well controlled with simvastatin. Physical exam: palpable bilateral cervical lymphadenopathy​ Laboratory results: lactate dehydrogenase, 265 U/L (280 U/L upper limit); Hemoglobulin, 10.8 g/dL; bilirubin, 1.3 mg/dL…

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A Simple Overview for Proteins Molecular Dynamics Simulations Using GROMACS

About Gromacs – Gromacs. s.d. Consulté le 5 mai 2023. www.gromacs.org/About_Gromacs Baker, D., Sali, A.: Protein structure prediction and structural genomics. Science 294(5540), 93–96 (2001). doi.org/10.1126/science.1065659 Beckstein, O., et al.: Ion channel gating: insights via molecular simulations. FEBS Lett. 555(1), 85–90 (2003). doi.org/10.1016/s0014-5793(03)01151-7 CrossRef  Google Scholar  Bowman, A.L., Ridder, L.,…

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Bristol Myers Squibb hiring Machine Learning/AI Scientist Computational Tissue Imaging Research, Translational Bioinformatics in Cambridge, MA

Working with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work…

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The Evolution from HG19 to HG38

Welcome to another blog post! ‍ Reference genomes are essential benchmarks of a species’ genome that facilitate the accurate comparison of individual genomes and are crucial tools for identifying genetic variants and diagnosing rare diseases. Here, we will explore the evolution of the human reference genome, focusing on the transition…

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The Henry M. Jackson Foundation for the Advancement of Military Medicine hiring Senior Bioinformatics Scientist in Bethesda, MD

Join the HJF Team!The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) is a nonprofit organization dedicated to advancing military medicine. We serve military, medical, academic and government clients by administering, managing and supporting preeminent scientific programs that benefit members of the armed forces and civilians alike….

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Bioinformatics Market Is Set To Reach USD 28.6 Billion By 2030 With CAGR Of 13.73% | Marketdigits

(MENAFN– GlobeNewsWire – Nasdaq) The Global Bioinformatics Market was valued USD 10.23 Billion in 2023 and projected to reach USD 28.6 Billion by 2030, growing at a CAGR of 13.73% during the forecast period of 2023-2030 Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report ” Bioinformatics…

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2024 Ggplot axis labels

Plot Titles, Axes and Legend Titles. One way to modify plot titles, axes and legend titles is through the labs() function in ggplot2.In order to add math notation to those labels, we can use the expression() function to specify the label text. For example, if we wanted to modify the…

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Pacritinib Shows Transfusion Independence Benefits in Myelofibrosis

Bart Scott, MD Professor, Transplantation Program Clinical Research Division Miklos Kohary and Natalia Zimonyi Kohary Endowed Chair Fred Hutchinson Cancer Center Seattle, WA Targeted Oncology: Could you summarize the approved Janus kinase (JAK) inhibitors for patients with myelofibrosis? BART SCOTT, MD: Ruxolitinib (Jakafi) was approved in 2011, fedratinib (Inrebic) in…

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Bioconductor – MCRestimate

DOI: 10.18129/B9.bioc.MCRestimate     Misclassification error estimation with cross-validation Bioconductor version: Release (3.6) This package includes a function for combining preprocessing and classification methods to calculate misclassification errors Author: Marc Johannes, Markus Ruschhaupt, Holger Froehlich, Ulrich Mansmann, Andreas Buness, Patrick Warnat, Wolfgang Huber, Axel Benner, Tim Beissbarth Maintainer: Marc Johannes…

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Topic Modelling with LDA: A Comprehensive Guide for Students

2/8/24, 5:59 PMtopic-modelling-lda.ipynb – Colaboratory 1/5# This Python 3 environment comes with many helpful analytics libraries installed # It is defined by the kaggle/python Docker image: # For example, here’s several helpful packages to load import numpy as np # linear algebra import pandas as pd # data processing, CSV…

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King’s College London hiring Research Associate in Translational Bioinformatics in London, England, United Kingdom

Job DescriptionThis is a Pre-Fellowship for early career researchers wanting to establish a career in MND translational research and become MND research leaders of the future. The postholder will have a leading role in an exciting new project funded by Motor Neurone Disease Association and MND Scotland. The project is…

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CRISPR/Cas9 are the Most Sought Genome Editing Tools

Company Logo Global Genome Editing Market Global Genome Editing Market Dublin, Feb. 09, 2024 (GLOBE NEWSWIRE) — The “Global Genome Editing Market, 2023-2035: Focus on Technology, Industry Trends and Forecasts” report has been added to ResearchAndMarkets.com‘s offering. The global genome editing market size for technologies is estimated to be worth…

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r – ggplot2 legend not appearing

The @benson23 answer is correct, if you want more control you can use manual scales for different aesthetics. If you use linetype in aes instead of fill, you will get a legend as above, if you like that more. library(tidyverse) df <- tribble( ~ tree, ~ o18, “A”, 15, “A”,…

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r – The optimal the Stack size for Rstudio on a Windows OS;

This question was caused by a typo or a problem that can no longer be reproduced. While similar questions may be on-topic here, this one was resolved in a way less likely to help future readers. What would be the optimal the Stack size for Rstudio (on a Windows OS)…

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Faulty DNA Disposal System Causes Inflammation

Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. Credit: Salk Institute One of the ways our cells respond to damage and infection is with what’s known as the innate immune system. While the innate immune response is the first…

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Bioconductor – genomation

DOI: 10.18129/B9.bioc.genomation     Summary, annotation and visualization of genomic data Bioconductor version: Release (3.6) A package for summary and annotation of genomic intervals. Users can visualize and quantify genomic intervals over pre-defined functional regions, such as promoters, exons, introns, etc. The genomic intervals represent regions with a defined chromosome…

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Create Box Plots in R using Plotly and ggplot2: Step-by-Step

Box Plots Using plotly library(plotly) # data sample data <- c(1, 2, 2, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 5) plot_ly(y = data, type = “box”) This code creates a box plot of the data provided in the data variable. You can further customize the…

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PCA from plink2 for SGDP using a pangenome and DeepVariant

Hi there, I’m doing my first experiments with PCA and UMAP as dimensionality reductions to visualize a dataset I’ve been working on. Basically, I used the samples from the SGDP which I then mapped on the human pangenome for, finally, calling small variants with DeepVariant. I moved on with some…

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Antimicrobial potential of Streptomyces coeruleofuscus SCJ isolated from microbiologically unexplored garden soil in Northwest Morocco

Zaman, S. B. et al. A review on antibiotic resistance: Alarm bells are ringing. Cureus doi.org/10.7759/cureus.1403 (2017). Article  PubMed  PubMed Central  Google Scholar  Peterson, E. & Kaur, P. Antibiotic resistance mechanisms in bacteria: Relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front. Microbiol. 9, 2928 (2018)….

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Gut Microbiota Impacts Bone Mineral Density in Older Women

The microbiota of the gut has an impact on bone mineral density (BMD) and osteoporosis, but the specific species involved and the underlying mechanisms remained largely unknown until now. A new study has found that Bacteroides vulgatus demonstrates a negative association with BMD, while serum valeric acid (VA) exhibits a…

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Bioinformatics Market is Set to Reach USD 28.6 Billion by

Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report “Bioinformatics Market”, by tools Type (BLAST, BioPerl, InterMine, Others), Services (Genome Sequencing, RNA sequencing, Metagenomic Analysis, Epigenomic, Others), Application (Drug discovery, Personalized medicine, Preventive medicine, Transcriptions, Metabolomics, Gene therapy, Others) Sectors (Medical Biotechnology, Animal Biotechnology, Plant Biotechnology, Environmental…

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Unveiling Roman Amphitheaters with a ggplot2 violin plot

[This article was first published on coding-the-past, and kindly contributed to R-bloggers]. (You can report issue about the content on this page here) Want to share your content on R-bloggers? click here if you have a blog, or here if you don’t. 1. What is a violin plot? A violin…

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Data Analytics Lab Assignment: R Scripts, Analysis, and

COURSE: CIT466 Data AnalyticsLab 2 SPRING 2024 Dr. Feras AlObeidat This is a group assignmentthat will result in a report based on the below questions. There can be a maximum of three students in each group. This assignment will assess your understanding of all R lab sessions covered in course…

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PRSice and R lm() show different association analysis output (coefficient, SE and P)

PRSice and R lm() show different association analysis output (coefficient, SE and P) 0 Hey, I am struggling to understand Why am I getting different association analysis output (coefficient, SE and P) between PRSice and lm() function in R. Not only the values, even the direction of association is different….

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KEGG ORTHOLOGY: K06121

KEGG ORTHOLOGY: K06121     ORTHOLOGY: K06121 Help Entry K06121                      KO                                      Symbol dhbC Name glycerol dehydratase medium subunit [EC:4.2.1.30] Pathway Reaction R01047   glycerol hydro-lyase (3-hydroxypropanal-forming) Brite KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism  09103 Lipid metabolism   00561 Glycerolipid metabolism    K06121  dhbC; glycerol dehydratase medium subunitEnzymes [BR:ko01000] 4. Lyases  4.2  Carbon-oxygen lyases   4.2.1  Hydro-lyases    4.2.1.30  glycerol dehydratase     K06121  dhbC; glycerol dehydratase medium subunit BRITE hierarchy Other DBs Genes…

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python – Reading files asynchronously hangs within Pytorch Dataset when DataLoader.num_workers > 1

I’m training a classifier on raw-bytes in binary files. Each file can be several megabytes long. I have a dataset with several millions of binaries in it. Loading all this data at once and keeping it all in memory is very expensive, so I wanted to write an IterableDataset to…

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Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

dc.contributor.author Lim, Ryan G dc.contributor.author Al-Dalahmah, Osama dc.contributor.author Wu, Jie dc.contributor.author Gold, Maxwell P dc.contributor.author Reidling, Jack C dc.contributor.author Tang, Guomei dc.contributor.author Adam, Miriam dc.contributor.author Dansu, David K dc.contributor.author Park, Hye-Jin dc.contributor.author Casaccia, Patrizia dc.contributor.author Miramontes, Ricardo dc.contributor.author Reyes-Ortiz, Andrea M dc.contributor.author Lau, Alice dc.contributor.author Hickman, Richard A dc.contributor.author Khan,…

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Treating the Untreatable with Precision Therapies – A $4 trillion Opportunity?

Precision Therapies For Targeted Results Precision therapies have always been the ultimate goal of medicine. Instead of drugs acting on multiple parts of the body, these therapies would only target one organ, one cell, or even one gene. In theory, not only would this be a lot more efficient, but…

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Sperm-specific histone H1 in highly condensed sperm nucleus of Sargassum horneri

Cho, C. et al. Haploinsufficiency of protamine-1 or-2 causes infertility in mice. Nat. Genet. 28, 82–86 (2001). Article  CAS  PubMed  Google Scholar  Oliva, R. Protamines and male infertility. Hum. Reprod. Update 12, 417–435 (2006). Article  CAS  PubMed  Google Scholar  Balhorn, R. The protamine family of sperm nuclear proteins. Genome Biol….

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Bhubaneswar ILS scientists discover direct interaction of circular RNAs with mRNAs in gene expression

In an extremely proud moment for Odisha, a team of researchers at the prestigious Institute of Life Sciences (ILS) in Bhubaneswar has made a groundbreaking discovery that suggests the role of direct interaction of circRNAs with mRNAs in gene expression regulation. The findings represent a novel method for illuminating the…

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Faulty DNA disposal system causes inflammatio

image:  Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. view more  Credit: Salk Institute LA JOLLA (February 8, 2024)—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from…

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Bioconductor – BioNERO

DOI: 10.18129/B9.bioc.BioNERO     This package is for version 3.15 of Bioconductor; for the stable, up-to-date release version, see BioNERO. Biological Network Reconstruction Omnibus Bioconductor version: 3.15 BioNERO aims to integrate all aspects of biological network inference in a single package, including data preprocessing, exploratory analyses, network inference, and analyses…

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Insight Global hiring Bioinformatics Software Engineer in Tennessee, United States

Job Description: 1) Use Nextflow to build bioinformatics pipelines that take FASTQ or BAM files as input and process them using bioinformatic tools. 2) Write Python/R scripts to process, summarize, and visualize outputs created by other tools. 3) Ensure that the pipeline is modular and flexible, with the ability to…

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Did COVID vaccines kill 14X more people than they saved?

Did a study just show that COVID-19 vaccines killed 14x more people than they saved?! Take a look at the viral claim, and find out what the facts really are!   Claim : COVID Vaccines Kill 14X More People Than They Saved! People are sharing an article (archive) by The…

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NetworkAnalyst

Starting from a list of gene IDs with optional expression values Starting from a single count table (RNAseq) or intensity table (microarray) Starting with several gene expression tables for meta-analysis Uploading raw RNAseq files (any species) for mapping & quantification Starting with a network file (sif, graphml, json) News &…

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2023 gene therapy research STAR Grant winners announced

At PacBio, enabling the promise of genomics to better human health cuts right to the core of everything we do.That’s why in 2023 we created the STAR (Student Travel Awarded Researcher) Grant program. This exciting funding opportunity is intended to assist up-and-coming researchers in genomics-aligned fields with sequencing services and…

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Love Data Week begins Monday | E-News

Researchers and data enthusiasts are invited to join the celebration by attending a series of workshops beginning Monday (Feb. 12) through Feb. 16 that will offer valuable insight and skill building for those interested in working with data. Whether you are taking the initial steps in working with data or…

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Chinese Scientist Filed Covid Sequence Weeks Before Official Release: Report

Beijing: A Chinese scientist sought to publish the genetic profile of the coronavirus two weeks before Beijing formally released the sequence, as per federal documents shared with a US congressional committee and released on Wednesday, The Washington Post reported. The delay may have slowed researchers’ work on tests, treatments, and…

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Problems rendering a quarto qmd file through jupyter in VS Code – JupyterHub

bj631 January 19, 2024, 10:45pm 1 I’m trying to preview a .qmd file using quarto with jupyter in VS Code. There is a little banner in the bottom right corner that shows up when trying to render the .qmd that says ” command ‘quarto.preview’ not found “. It is a…

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Genetic Sequence of Coronavirus Was Submitted to US Database 2 Weeks Before China’s Official Disclosure, Documents Show

The genetic sequence itself doesn’t indicate the origins of the virus that causes Covid-19. (Alissa Eckert/Dan Higgins/CDC) The genetic sequence of SARS-CoV-2, the virus that causes COVID-19, was submitted to a National Institutes of Health database two weeks before its release by the Chinese regime, according to documents that were…

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ggplot2 – Make more room for lables in ggplot in r

Is there a way to have this plot squeezed a little so labels of extreme cases (A and G) have could show up completely. code: x <- LETTERS[1:11] y <- c(9, 4, 6, 8, 5, 7, -9, -4, -6, -8, -5) z <- seq(-1, 1, by = 0.2) dat <-…

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ADC Therapeutics (ADCT) Rises 43% in a Month: Here’s Why

ADC Therapeutics ADCT is a commercial-stage biotech company focused on developing novel antibody-drug conjugates (ADC) to treat patients with hematologic malignancies and solid tumors. Currently, ADC Therapeutics has only one marketed drug in its portfolio, Zynlonta, which the FDA approves to treat relapsed or refractory (r/r) diffuse large B-cell lymphoma…

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Chinese Lab Sequenced COVID-19 Weeks Before Beijing Disclosed Data

Once again the timeline surrounding the COVID-19 pandemic has shifted – this time with the revelation that a researcher based in Beijing had already mapped the COVID-19 sequence two weeks before the CCP revealed its details to the world, raising questions over what other critical information China may have obscured…

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Adding Pembrolizumab to Lenvatinib Shows ‘Encouraging’ DOR in Advanced HCC

Adding Pembrolizumab to Lenvatinib Shows ‘Encouraging’ DOR in Advanced HCC Compared with lenvatinib (Lenvima) plus placebo, adding pembrolizumab (Keytruda) to lenvatinib resulted in consistent overall (OS) and progression-free survival (PFS) outcomes previously found in the phase 3 LEAP-002 trial (NCT03713593) of patients with advanced hepatocellular carcinoma (HCC). However, 35% of…

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NifH database for taxonomic assignment in qiime2 – General Discussion

JThurston (Josh Thurston) January 19, 2024, 8:05pm 1 Hi all! I’m currently working through a Qiime2 pipeline analysing Illumina miseq paired-end amplicon data. I’ve successfully analysed bacterial (16s) amplicons from importing, filtering through to taxonomic assignment. However, I also have amplicon data for a functional gene (nifH; nitrogenase for N2…

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Study Highlights Treatment Patterns, Costs for DLBCL Not Treated With Stem Cell Transplant

New research highlights treatment patterns, health care resource utilization (HCRU), and costs associated with patients who have diffuse large B-cell lymphoma (DLBCL) who did not undergo stem cell transplantation in the second-line setting between 2009 and 2020. Of a 750-patient cohort, 86.8% received rituximab plus cyclophosphamide, doxorubicin, vincristine (Oncovin), and…

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Community-scale models of microbiomes: Articulating metabolic modelling and metagenome sequencing

Review doi: 10.1111/1751-7915.14396. Online ahead of print. Affiliations Expand Affiliations 1 Quadram Institute Bioscience, Norwich, UK. 2 Earlham Institute, Norwich, UK. 3 Inria, University of Bordeaux, INRAE, Talence, France. 4 University of Bordeaux, CNRS, Bordeaux INP, LaBRI, UMR 5800, Talence, France. 5 INRAE STLO¸University of Rennes, Rennes, France. 6 INRAE,…

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Prashant Mehta: My thoughts on developments in DLBCL management

Prashant Mehta, Senior Consultant and Assistant Professor in the Department of Medical Oncology/Hematology-oncology and Bone marrow transplantation at the Amrita Hospital, Faridabad, shared a thread on X/Twitter: “My thoughts on developments in Diffuse Large B Cell Lymphoma (DLBCL) management: Despite several combination studies with R-CHOP, in the last 20 years…

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Cluster Information – SLING user documentation

Slurm offers a range of commands for interacting with the cluster. In this section, we will explore some examples of using the sinfo, squeue, scontrol, and sacct commands, which provide valuable insights into the cluster’s configuration and status. For comprehensive information on all the commands supported by Slurm, please refer…

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Chinese scientist revealed Covid sequence weeks ahead of official release: US committee

Public health experts who examined the documents said the experience showed how there was a chance to find out more information about the virus early on in the global health emergency Image Courtesy Agencies According to federal documents provided with a US congressional committee and made public on Wednesday, a…

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Sen. Marshall Calls For Halt of Gain-of-Function Studies, Funding Chinese Research

Sen. Roger Marshall (R-Kan.) speaks on border security and Title 42 during a press conference at the U.S. Capitol in Washington on May 11, 2023. (Kevin Dietsch/Getty Images) It has been four years since patients sickened with unexplained pneumonia started appearing at hospitals in the central Chinese city of Wuhan. But…

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Postdoc/assistant professor in molecular biology and bioinformatics: Structural variations associated to circular DNA in cancer – University of Copenhagen – job portal

Job Portal Postdoc/assistant professor in molecular biology and bioinformatics: Structural variations associated to circular DNA in cancer Department of Biology, Faculty of Science at University of Copenhagen is offering a position in molecular biology and bioinformatics for a Postdoc/assistant professor for the analysis of extrachromosomal circular DNA in 1 April…

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UC San Diego’s Bioengineering Team Uses TSCC at SDSC for Bioinformatics Tool

Jan. 19, 2024 — Over 18 million people worldwide are annually diagnosed with cancer, with each case hiding many mutations in its genome. Understanding these mutations furthers cancer research, while also providing a deeper understanding to create possible cures, therapies and prevention strategies. The Triton Shared Computer Cluster at the…

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r – How can I change position x-axis ticks in ggplot of regression

Having completed my regression equation and F-statistic I have been able to plot a regression curve with confidence limits through my set of data points which I am happy with. My x variable is number of days from start of observations which runs for exactly one year (17 Jan 2009…

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r – RStudio loading the wrong file

Closed. This question needs debugging details. It is not currently accepting answers. I’m trying to load an .RData file and a different file appears in the environment pane. My code: load(“C:/Users/lisam/Desktop/PhD/comp3 POPANE/analysis/R/segData/segData_S5/newlist_allfiles_ps_S5.RData”) The name of the file that loads: newlist_allfiles_S5 I’ve also tried using: setwd(“C:/Users/lisam/Desktop/PhD/comp3 POPANE/analysis/R/segData/segData_S5”) load (“newlist_allfiles_ps_S5.RData”) Have also…

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Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Capturing proteins associated with SARS-CoV-2 virions To identify host cell proteins potentially present in extracellular SARS-CoV-2 virions, viral particles were produced from two lung epithelial cell models, A549 cells overexpressing ACE2 receptor (A549-ACE2) and Calu-3 cells that naturally express ACE2 receptor and TMPRSS2. Following infection with the D614G SARS-CoV-2 strain32,…

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Genomic insights into Plasmodium vivax population structure and diversity in central Africa | Malaria Journal

Hamblin MT, Di Rienzo A. Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus. Am J Hum Genet. 2000;66:1669–79. Article  CAS  PubMed  PubMed Central  Google Scholar  Hamblin MT, Thompson EE, Di Rienzo A. Complex signatures of natural selection at the Duffy blood group…

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DESeq2 (zeros in the taxa table) – Other Bioinformatics Tools

komal (Komalk) January 19, 2024, 12:02pm 1 Hi this is regarding DESeq2. I first created a phyloseq object from qiime2 artifacts and then subjected it to Deseq2. At one step I got a errorError in estimateSizeFactorsForMatrix(counts(object), locfunc = locfunc, :every gene contains at least one zero, cannot compute log geometric…

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Senior Bioinformatics Research Scientist – Appcast

We are seeking a talented, highly motivated Senior Bioinformatics Research Scientist to lead our bioinformatics pipeline and develop innovative solutions for analyzing and visualizing omics data related to innate immune signaling projects. The candidate will work both collaboratively and independently on projects within the Kanneganti lab in the Department of…

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r – Log Scale on Reverse Cumulative Distribution Plot in ggplot2

There’s a couple of ways to do this. You could simply log manually and inverse transform the labels in scale_y_continuous rnorm(64) %>% tibble(kbps = .) %>% ggplot() + stat_ecdf(aes(x = kbps, y = log10(1 – after_stat(y))), pad = FALSE) + scale_y_continuous(‘1 – cdf (log scale)’, breaks = seq(-3, 0), labels…

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r – Clustered standard error bars for two-way bar chart in ggplot

I am looking for help with code for adding clustered standard errors to a two-way bar chart generated using ggplot. All of the packages I find are for regression results. I have data in which 1200 respondents each rated 10 profiles (n=12,000). I want to plot the means (Y) by…

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Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals

The specific environmental/history/collection context The Huseby Klev materials were unearthed and collected by archaeologists (including two of the co-authors of this article) during the excavation of this coastal hunter-fisher-gatherer site in the 90s50. The material assemblage was rich and well preserved: human bones, animal bones, plant remains and pieces of…

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Detection of DNA methylation signatures through the lens of genomic imprinting

Animals and samples The study included 10 pigs, 8 pigs were bred at the INRAE experimental farm (doi.org/doi.org/10.15454/1.5572415481185847E12) and 2 pigs come from breeding organizations in accordance with the French and European legislation on animal welfare. The animals belong to the same family, except for one LW animal. Animals were…

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Problem with DRAGEN RNAseq hashtable directory

Problem with DRAGEN RNAseq hashtable directory 1 Dear all, Recently I wrote a code to work with DRAGEN and RNAseq pipeline. I use this command: /opt/edico/bin/dragen -f -l \ -r refdir \ -1 ${forward} \ -2 ${reverse} \ -a ${gtf} \ –output-dir output/${sample} \ –output-file-prefix ${sample} \ –RGID ${sample}_group_id \…

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N6-methyladenosine modification positively regulate Japanese encephalitis virus replication | Virology Journal

Burgess HM, Depledge DP, Thompson L, Srinivas KP, Grande RC, Vink EI, Abebe JS, Blackaby WP, Hendrick A, Albertella MR, Kouzarides T, Stapleford KA, Wilson AC, Mohr I. Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes Dev. 2021;35:1005–19. Article  CAS  PubMed  PubMed Central  Google Scholar  Chambers…

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Researchers develop a potential one-minute COVID-19 test inspired by bioluminescence

Cold, flu and COVID-19 season brings that now-familiar ritual: swab, wait, look at the result. But what if, instead of taking 15 minutes or more, a test could quickly determine whether you have COVID-19 with a glowing chemical? Now, in ACS Central Science, researchers describe a potential COVID-19 test inspired…

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Federal secrets spill on COVID origins amid rodent research on risks of lab mods, vax in pregnancy

The National Institutes of Health appears to be struggling to hide its dirty laundry on COVID-19 origins against a rash of leaks, congressional probes, and Freedom of Information Act requests, even when officials are determined to thwart sunlight. The ongoing exposure of their communications and actions isn’t the only thing…

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Causality-enriched epigenetic age uncouples damage and adaptation

Gladyshev, V. N. et al. Molecular damage in aging. Nat. Aging 1, 1096–1106 (2021). Article  PubMed  PubMed Central  Google Scholar  Sziráki, A., Tyshkovskiy, A. & Gladyshev, V. N. Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell 17, e12738 (2018). Article  PubMed …

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Deleting a column from data frame and then running DESeq2

Forgive me if this post is messy, I’m new to this! I’m analyzing RNA Seq data and found that one of my samples is an outlier (sample AV17). I’m trying to exclude it from my analysis, but whenever I do, using this code: dds = subset(countData, select = -c(AV17) ),…

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Career Associated – International Centre of Insect Physiology and Ecology (icipe)

All jobs > Research > International Centre of Insect Physiology and Ecology (icipe) – Postdoctoral Research Fellow (Bioinformatics) International Centre of Insect Physiology and Ecology (icipe) Get a free C.V. review by sending your C.V. to submitcv@careerassociated.com or click the following link. Submit C.V.! use the subject heading REVIEW. IMPORTANT: Read the…

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The biggest private biotech investments in December 2023

The companies Tome Biosciences, Bicara Therapeutics, and Seismic Therapeutic bagged the biggest biotech investments in December 2023. Around the world, food, immunology, oncology, central nervous system (CNS), and biofermentation players attracted the biggest funding rounds overall.  Although December is generally a quiet time for biotech fundraising, there were still some…

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r – Percent stacked barchart failed in ggplot2

While we don’t have your data, the issue is that you map a factor or character (aka SmokeType) on the y aesthetic, which when used with geom_col gives weird charts and axes scales which is evident from both of your plots. From your charts and code you want a barchart…

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r – Move positioning of x axis labels in ggplot without hjust or vjust

Using some sample data from BLS below, I’m trying to make a faceted plot of spending categories by income bracket. Because some of the label names are long, I have them rotated 90 degrees. I have been using hjust and vjust to move around the labels a bit, but I…

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Five biotech companies taking Florida by storm

Florida is currently home to the nation’s second-largest medical device manufacturing industry, second-largest pharmaceuticals manufacturing industry, and the fourth-largest biotech R&D industry, making it a large life sciences hub within the U.S. So, in this article, with more than 2,300 establishments operating within the Florida life sciences industry as a…

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Having Trouble Loading Required Packages : Lazy-Load database is corrupt – General

Hi, I am very new to R-Studio but a few months I had taken an 8-week course in which I was taught to use R-Studio for academic purposes. I recently decided to review some of the exercises we were provided with. However, I have now started to have trouble loading…

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BWA Index Referencing Failed. Possible Reason and Solutions?

BWA Index Referencing Failed. Possible Reason and Solutions? 0 Script: echo “STEP 2: Map to reference using BWA-MEM” #BWA index reference bwa index ${ref} *#Path for ref variable has been defined* #BWA alignment bwa mem -t 4 -R “@RG\tID:SRR062634\tPL:ILLUMINA\tSM:SRR062634” ${ref} ${reads}/SRR062634_1.filt.fastq.gz ${reads}/SRR062634_2.filt.fastq.gz > ${aligned_reads}/SRR062634.paired.sam **Error:** . . . . [BWTIncConstructFromPacked]…

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ggplot2 – Overlaying a background with hexagonal points on ggplot r

I’m desperately trying to add inventory data (available online, as in this reproducible example below) in ggplot with a background of France, so that I can visualize the areas where there are no records of my species. However, I want to do it with hexagons and not points. So, I…

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My R scripts are blank and with 0 file size – RStudio IDE

I previously used R3.6.3 and recently updated to R4.3.1 because of some package installments. I wrote a new script (A) using R4.3.1 but I found I couldn’t open my old scripts, so sometimes I switched to R3.6.3 to check other codes. It has been worked well until a few days…

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Comparison of capture-based mtDNA sequencing performance between MGI and illumina sequencing platforms in various sample types | BMC Genomics

Hu T, Chitnis N, Monos D, Dinh A. Next-generation sequencing technologies: an overview. Hum Immunol. 2021;82(11):801–11. Article  CAS  Google Scholar  Jeon SA, Park JL, Park SJ, Kim JH, Goh SH, Han JY, Kim SY. Comparison between MGI and Illumina sequencing platforms for whole genome sequencing. Genes Genomics. 2021;43(7):713–24. Article  CAS …

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Bioconductor – mgu74cv2probe

DOI: 10.18129/B9.bioc.mgu74cv2probe     This package is for version 3.12 of Bioconductor; for the stable, up-to-date release version, see mgu74cv2probe. Probe sequence data for microarrays of type mgu74cv2 Bioconductor version: 3.12 This package was automatically created by package AnnotationForge version 1.11.21. The probe sequence data was obtained from www.affymetrix.com. The…

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Memorial Sloan Kettering Cancer Center hiring Bioinformatics Software Engineer III – Chan Lab in New York, NY

 The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative…

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miR-195b is required for proper cellular homeostasis in the elderly

Expression pattern of miR-195 during embryonic development We analyzed the expression pattern of miR-195 by in situ hybridization at two distinct developmental stages in mouse embryos. Whole-mount in situ hybridization at E10.5, demonstrated a wide expression of miR-195 along the entire embryo, including the central nervous system, the cardiopharyngeal area,…

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ConciseR data.table helper – ChatGPT GPT Store

ConciseR data.table helper is an expert GPT model focused on providing concise answers and explanations for R programming, data.table, and ggplot2. The model is tailored to assist users with merging data.tables, plotting time series data, optimizing data.table operations, creating multi-panel plots, running functions across multiple variables, creating multiple variables, and…

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Installing R and Setting Up RStudio

Here, we will discuss how to install R and set up RStudio. R is an open-source and free to use application primarily used for computing, data analysis, data visualization and statistical analysis. R offers variety of functionalities that includes but not limited to: You can install R at www.r-project.org. Click…

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Stochastic biological system-of-systems modelling for iPSC culture

Cell proliferation and aggregation dynamics modeling The aggregation process is characterized by the dynamic evolution of a density profile of aggregates. Let \(\phi (x,t)\) denote the average number of aggregates or clusters of size \(x\) (i.e., mass and volume) at time \(t\), where mass is equal to a buoyant density…

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Bioconductor – hu35ksubd.db

DOI: 10.18129/B9.bioc.hu35ksubd.db     This package is for version 3.12 of Bioconductor; for the stable, up-to-date release version, see hu35ksubd.db. Affymetrix Human Genome HU35K Set annotation data (chip hu35ksubd) Bioconductor version: 3.12 Affymetrix Human Genome HU35K Set annotation data (chip hu35ksubd) assembled using data from public repositories Author: Marc Carlson…

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10 Kaggle Competitions Every Young Data Scientist Should Check Out

Unlike high school lessons and exams, competitions can offer some much-needed practical experience. Participating in data science competitions not only allows you to hone your coding and analytical skills but also provides hands-on experience in tackling real-world problems. These competitions act as a dynamic playground where you can put your…

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Google’s AI Spin-Off Isomorphic Labs Strikes Big Pharma Deals, Paving the Way for Future of Drug Discovery – Alphabet (NASDAQ:GOOG), Alphabet (NASDAQ:GOOGL), Eli Lilly (NYSE:LLY), Novartis (NYSE:NVS)

Isomorphic Labs, a London-based spin-out of Alphabet Inc GOOG GOOGL Google’s AI R&D division DeepMind, has announced strategic partnerships with Eli Lilly And Co LLY and Novartis AG NVS.  These alliances aim to leverage AI to discover new medications to treat diseases.  The combined value of these deals is around $3 billion.  Isomorphic will receive $45 million upfront from Eli Lilly, potentially…

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Post-Doctoral and PhD positions, La Sapienza University, Italy

Post-Doctoral and PhD positions: Join our vibrant team! We are currently hiring for various positions – Curators, Post-Docs, PhD, and Master Students. If you are passionate about Bioinformatics and Computational Biology, with a keen interest in Systems Biology, Network-Based, Multi-omic Integration, and deep learning, we want to hear from you!…

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ggplot2 – Manipulating axes/display for line chart in R

This question already has answers here: Closed 12 hours ago. I am fairly new to R and working on a practice case study to sharpen my skills. I’m running into issues with the line chart visualization for this data. I need to display monthly data, but I would like to…

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r – Maintaining Factor Order in ggplot

I am attempting to combine two data sets and chart types into a single ggplot. I want to plot the main data in a line/connected dot plot (two observations of the same kind within each of 5 categories), and a set of n random observations in a 6th category as…

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Introduction to R and RStudio, Thu, Jan 25, 2024, 12:00 PM

Join us for a 3-part workshop series meant to introduce you to R and RStudio. We will walk through the basics of how to handle data in R and how you can create data visualizations! Please note: There is one meetup link per workshop, please register for each workshop separately….

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Clinical algorithm model based on cfDNA to predict SLE disease activity

Background: Circulating cell-free DNA (cfDNA) has been widely used as a new liquid-biopsy marker. Dysregulation of cfDNA has been found in patients with systemic lupus erythematosus (SLE). However, the detailed association between cfDNA and SLE has not been thoroughly studied. Methods: Plasma samples were collected from 88 patients with active…

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Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis

CDC. (ed CDC) (U.S. Department of Health and Human Services, CDC; 2019, Atlanta, GA, 2019). Krismer, B., Weidenmaier, C., Zipperer, A. & Peschel, A. The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota. Nat. Rev. Microbiol. 15, 675–687 (2017). Article  CAS  PubMed  Google Scholar  Somerville, G….

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eS6 – Ribosomal Proteins

A, 3-D models of human ribosomal subunits based on PDB entries 3J3D and 3J3A (for SSU r-proteins), and on 3J3F and 3J3B (for LSU r-proteins) highlighting the position of individual r-proteins on mature subunits. On small subunits, the 18S rRNA is shown in grey; on large subunits, the 5S, 5.8S…

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R packages: Missing “suggests” dependency during installation. – General

Hi folks! I’ve encountered an intriguing issue while conducting a package installation process. Currently, I’m working on R version 4.2.1 within the Posit Workbench 2023.03.1+446.pro1, “Cherry Blossom” environment. I’ve developed a package named APIUtilizeR and subsequently uploaded it to our internal POSIT Package Manager. Within the DESCRIPTION file of this…

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