Tag: resonance

Shedding Light on BIA-ALCL Risks

In a society that celebrates individuality and self-expression, the journey to aesthetics takes many forms. One such road, taken by countless women seeking empowerment and confidence, is breast augmentation. This blog dives deep into the dark and flip side of breast augmentation- Allergan breast implant lawsuits. Before answering the query…

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Help Fight Cancer with a Radiology Technologist Job

Radiology technologists play a vital role in cancer care. Also known as radiographers, these medical specialists perform important imaging tests on patients to create detailed images of targeted areas of the body. The images are then interpreted by a physician, who may use the results to help detect and diagnose…

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Achievements, accolades highlight past year at VUMC | VUMC Reporter

  Editor’s note — the following is a roundup of the news that made headlines at Vanderbilt University Medical Center in 2023.   Whole-genome sequencing agreement Nashville Biosciences LLC, a wholly owned subsidiary of Vanderbilt University Medical Center, and Illumina Inc., a global leader in DNA sequencing and array-based technologies,…

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Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient

Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely,…

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Must-Have Equipment for Modern Research Labs

The progression of scientific knowledge and technological innovation relies heavily on the pivotal role of research laboratories. These centers of inquiry are furnished with state-of-the-art tools, providing researchers with the means to delve into uncharted territories and achieve groundbreaking discoveries. To keep pace with the ever-evolving landscape of technology, contemporary…

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ENPICOM and Carterra Advance Antibody Screening

14 December 2023 Science Salt Lake City, Utah, USA and Hertogenbosch, Netherlands – December 11, 2023 – Life Science Newswire – Carterra Inc., the world leader in label-free high-throughput antibody discovery and development, and ENPICOM B.V., an innovative bioinformatics software solutions provider, announced today a collaboration to streamline the analysis…

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Harnessing Nanomedicine to Combat Hepatic Fibrosis

Understanding nanomedicinesNanomedicine in hepatic fibrosis diagnosisNanomedicine in hepatic fibrosis treatmentNanomedicine in drug delivery  Nanomedicine in targeted drug delivery  Future perspectivesReferencesFurther reading Hepatic fibrosis is an abnormal wound-healing response triggered by chronic liver diseases, including non-alcoholic fatty liver disease, viral or alcoholic hepatitis, and Wilson’s disease. The response is characterized by…

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Genetic architecture of cardiac dynamic flow volumes

Virani, S. S. et al. Heart disease and stroke statistics-2021 update: a report from the American Heart Association. Circulation 143, e254–e743 (2021). Article  PubMed  Google Scholar  Nauffal, V. et al. Genetics of myocardial interstitial fibrosis in the human heart and association with disease. Nat. Genet. 55, 777–786 (2023). Article  CAS …

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Learning from cerebrospinal fluid drug-resistant HIV escape-associated encephalitis: a case report | Virology Journal

A 27-year-old HIV-positive Chinese Manchu male complained of intermittent headache, nausea, and vomiting (non-projectile vomiting three times in total) for two weeks in January 2022. No fever, amaurosis, or unconsciousness were presented. He denied preceding travel or unusual animal exposures. He was diagnosed with HIV infection five years ago and…

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A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging

Cell culture conditions Unless otherwise stated, cells were cultured with DMEM (Sigma Aldrich; #D6429) and 4.5 g/l glucose, phenol red, 10% FBS, and 1% penicillin/streptomycin with pH 7.4 and were incubated at 37 °C, 5% CO2, and 95% relative humidity. Wild-type HepG2 (#300198), HEK293 (#300192), and MCF-7 (#300273) were derived from CLS…

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Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes | Cardiovascular Diabetology

American Diabetes A. Economic costs of Diabetes in the U.S. in 2017. Diabetes Care. 2018;41(5):917–28. Article  Google Scholar  Linssen PBC, Veugen MGJ, Henry RMA, van der Kallen CJH, Kroon AA, Schram MT, Brunner-La Rocca HP, Stehouwer CDA. Associations of (pre)Diabetes with right ventricular and atrial structure and function: the Maastricht…

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FDA Extends Review Time for Italfarmaco’s Duchenne Agent Givinostat

Weeks before a decision was expected to be made for Italfarmaco’s investigational agent givinostat, the FDA informed the company it has extended the review process, with a new scheduled PDUFA of March 21, 2024. Givinostat, a proprietary histone deacetylase (HDAC) inhibitor, is currently in development as a treatment for Duchenne…

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Mitophagy in human health, ageing and disease

Palikaras, K., Lionaki, E. & Tavernarakis, N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat. Cell Biol. 20, 1013–1022 (2018). Article  CAS  PubMed  Google Scholar  Palikaras, K., Lionaki, E. & Tavernarakis, N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521, 525–528 (2015). Article …

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Innovative Engineering Solutions for Personalised Cancer Therapies

 Innovative engineering solutions have emerged as a cornerstone in personalised cancer therapies, heralding a new era in oncological treatment. FREMONT, CA: Over the past few years, the landscape of cancer treatment has undergone an extreme transformation through the adoption of precision medicine. This approach tailors therapies to individual patients, considering their…

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The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking

Bacterial strains and growth conditions Veillonella parvula SKV38 was grown in SK medium (10 g/L tryptone [Difco], 10 g/L yeast extract [Difco], 0.4 g/L disodium phosphate, 2 g/L sodium chloride, and 10 ml/L 60% [wt/vol] sodium DL-lactate; described in ref. 51. Cultures were incubated at 37 °C in anaerobic conditions, either in anaerobic bags (GENbag anaero;…

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Taxonomic and environmental distribution of bacterial amino acid auxotrophies

Tripp, H. J. et al. SAR11 marine bacteria require exogenous reduced sulphur for growth. Nature 452, 741–744 (2008). Article  ADS  CAS  PubMed  Google Scholar  Yu, X. J., Walker, D. H., Liu, Y. & Zhang, L. Amino acid biosynthesis deficiency in bacteria associated with human and animal hosts. Infect. Genet. Evol….

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Record Store Day Guide To 14 Unreleased & Reissued Jazz Recordings: Brubeck, Evans, Jamal & More

Rather than provide our usual detailed reviews of these never-before-released and/or reissued jazz recordings, we will instead provide a summary of each in alphabetical order by artist. While we see some of the usual suspects such as Bill Evans, Wes Montgomery, Charles Mingus, and Oscar Peterson, we also see Les…

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CRISPR/Cas12a trans-cleavage triggered by cleavage ligation of dumbbell DNA for specific detection of human 8-oxoguanine DNA glycosylase activity

Poetsch AR (2020) The genomics of oxidative DNA damage, repair, and resulting mutagenesis. Comput Struct Biotechnol J 18:207–219. doi.org/10.1016/j.csbj.2019.12.013 Article  CAS  PubMed  PubMed Central  Google Scholar  Ba X, Aguilera-Aguirre L, Rashid QT, Bacsi A, Radak Z, Sur S, Hosoki K, Hegde ML, Boldogh I (2014) The role of 8-oxoguanine DNA…

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MD Anderson Research Highlights for November 15, 2023

Newswise — HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent…

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Diagnosis of Two meningitis Cases caused by Rickettsia felis

Introduction Rickettsia felis belongs to the transitional group in the genus Rickettsia and is mainly transmitted by the cat flea (Ctenocephalides felis) but has been detected in a variety of arthropods including mosquitoes, ticks, and mites.1 Flea-borne spotted fever is caused by R. felis, with symptoms including fever, headache, and…

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Predicting multiple conformations via sequence clustering and AlphaFold2

AlphaFold2 (AF2) 1 has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein’s biological function often depends on multiple conformational substates2, and disease-causing point mutations often cause population changes within these substates3,4. We demonstrate that clustering a multiple sequence alignment (MSA) by sequence similarity enables AF2…

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Phase 3 Trial Demonstrates Benefits to Mavacamten Treatment in Hypertrophic Cardiomyopathy

In an interview with Pharmacy Times, study author Amy Sehnert MD, vice president, global program lead of CV Transition Assets at Bristol Myers Squibb, discusses the significance of the EXPLORER-HCM phase 3 trial and the treatment benefit of mavacamten in patients with and without gene variants. Sehnert also highlights the…

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Case of Spine Infection with Brucella melitensis

Introduction Brucellosis is a common zoonotic infection in most of the developing regions of the world, severely affecting livestock productivity and human health. It caused by a small, nonmotile gram-negative coccobacillus of the genus Brucella. Among reported human brucellosis cases, the pathogenic strain B. melitensis is the most frequently encountered.1,2…

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Which Is The Best Example Of A Scientific Discovery Resulting From New Technology?

The Discovery of Gravitational Waves The discovery of gravitational waves stands as one of the most groundbreaking scientific achievements in recent decades. This incredible feat was made possible through the utilization of new technology and the collaboration of scientists from around the globe. Gravitational waves were first predicted by Albert…

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Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study

Abstract Up to 40% of patients with diffuse large B-cell lymphoma (DLBCL) are refractory to or relapse after first-line therapy, highlighting the need for better treatments. Mosunetuzumab is a CD20 × CD3 bispecific antibody that engages and redirects T cells to eliminate malignant B cells. In this phase 2, open-label study…

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Diagnostics | Free Full-Text | CNS Involvement of DLBCL Presenting with an Unusual Non-Enhancing Infiltrative Mass

A 61-year-old woman presented to our emergency department with a fever, reaching up to 38.5 degrees Celsius, accompanied by general malaise, poor appetite, and muscle soreness. She had a medical history of diffuse large B-cell lymphoma (DLBCL) which presented as multiple axillary lymph nodes, characterized by double expression and stage…

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Madrigal Pharmaceuticals Presents New Data from the Phase 3

Data to be featured in an oral presentation at the American Association for the Study of Liver Diseases (AASLD) Liver Meeting® Analyses from comprehensive set of noninvasive tests used in MAESTRO-NASH provide new insights on strategies to identify patients and measure response to resmetirom A significant majority (>70%) of patients…

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Positive Results for Resmetirom for Nonalcoholic Fatty Liver Disease

Patients with nonalcoholic fatty liver disease (NAFLD) and presumed nonalcoholic steatohepatitis (NASH) met key primary and secondary endpoints in a 52-week phase 3 safety and tolerability study of resmetirom. Results of the study by Stephen Harrison, M.D., founder of Pinnacle Clinical Research, and colleagues were published last month in Nature…

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Fonsecaea monophora causing cerebral phaeohyphomycosis

Introduction Phaeohyphomycosis (PHM) is a group of superficial and deep mycoses, including central nervous system (CNS) infections, pulmonary infections, cutaneous and subcutaneous infections, associated with high mortality and caused by dematiaceous fungi that have brown-pigmented cell walls due to the formation of melanin.1,2 Previously, fungal brain infections generally occurred in…

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QUARTERLY REPORT Q3 2023: Re-evaluation of SPARKLE Phase 3 Study Images Progresses According to Plan -November 08, 2023 at 01:31 am EST

KEY EVENTS IN Q3 2023 Re-evaluation required after intra-reader inconsistency in scoring of images from phase 3 study SPARKLE Ascelia Pharma significantly reduces organization to reach SPARKLE headline results Ascelia Pharma to reach headline results from SPARKLE re-evaluation by May 2024 with current funding KEY EVENTS AFTER THE PERIOD Ascelia…

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Ch. 17 – + Cl 2 AlCl 3 Cl + HCl 17-64 Furan undergoes electrophilic aromatic substitution more

Preview text + Cl 2 AlCl 3 Cl + HCl 17-64 Furan undergoes electrophilic aromatic substitution more readily than benzene; mild reagents and conditions are sufficient. For example, furan reacts with bromine to give 2- bromofuran. (a) Propose mechanisms for the bromination of furan at the 2-position and at the…

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Expression profiles of circRNAs and biomarkers for COPD

Introduction Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease featured by airflow obstruction with high prevalence, morbidity, and mortality. It is reported that COPD is the third leading cause of death globally at present, and the incidence of COPD in adults over 40 years is more than…

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Development of a separation platform comprising magnetic beads combined with the CRISPR/Cas12a system enabling ultrasensitive and rapid detection of miRNA-21

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR (2005) MicroRNA expression profiles classify human cancers. Nature 4357043:834–838 Article  Google Scholar  Volinia S, Calin GA, Liu C-G, Ambs S, Cimmino A,…

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Genes | Free Full-Text | Unraveling the Genetic Threads of History: mtDNA HVS-I Analysis Reveals the Ancient Past of the Aburra Valley

1. Introduction The Antioquia region has played a pivotal role in the pre-Hispanic history of South America, serving as a gateway for the initial human migrations to the continent and as a hub for the development of a sophisticated culture deeply rooted in the utilization of natural resources and advanced…

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Scientists train AI to illuminate drugs’ impact

An ideal medicine for one person may prove ineffective or harmful for someone else, and predicting who could benefit from a given drug has been difficult. Now, an international team led by neuroscientist Kirill Martemyanov, Ph.D., based at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, is…

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SpringWorks Therapeutics Announces Presentation of

– Nirogacestat Treatment Demonstrated Rapid and Sustained Improvements in Functional Status Compared to Placebo Across Multiple Assessment Tools – STAMFORD, Conn., Nov. 01, 2023 (GLOBE NEWSWIRE) — SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, today…

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Unraveling Protein Structures: The Revolution of AlphaFold

Unraveling Protein Structures: The Revolution of AlphaFold Introduction The Central Dogma of Molecular Biology Experimental Methods for Protein Structure Determination The AlphaFold Artificial Intelligence System AlphaFold’s Architecture Overview Section 1: Generating the Initial Multiple Sequence Alignment (MSA) Section 2: The Evoformer Neural Network Section 3: The Structure Module Iterative Process…

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Circulating DNA and frequency of colorectal cancer brain metastases in a presumed high-risk group

The study was approved by The Central Denmark Region Committees on Health Research Ethics (1-10-72-269-20), and it was prospectively registered with ClinicalTrials.gov (ClinicalTrials.gov identifier: NCT05185557). The research was carried out according to the principles set out in the Declaration of Helsinki 1964 and all subsequent revisions. Written and orally informed…

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Revolutionizing Protein Structure Prediction: The Lasker Prize-Winning AlphaFold AI System Takes Biomedical Sciences by Storm

2023-10-30 03:04:42 He Lasker Prize for Basic Medical Research 2023 enhances the value of an artificial intelligence system that predicts the three-dimensional structure of proteins from their one-dimensional sequence of amino acids. This proposal opens a path to great discoveries in the Biomedical sciences in a shorter time. Proteins play…

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Early and sensitive detection of pathogens fo

Article Highlight | 28-Oct-2023 Research image: Schematic representation of the portable fiber optic sensing platform for detecting SARS-CoV-2 in sewage water. view more  Credit: All rights reserved. Infectious diseases severely threaten public health and global biosafety. In addition to transmission through the air, pathogenic microorganisms have also been detected in environmental…

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Screening of genes interacting with high myopia and neuropsychiatric disorders

Studies have shown that patients with high myopia have structural changes in their brain white matter, which are important factors contributing to neuropsychiatric disorders16,17. In this study, causative genes for neuropsychiatric disorders were found to account for 22.69% of strongly pathogenic genes in patients with HM, which represents the highest…

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Breast implant-associated anaplastic large cell lymphoma

INTRODUCTION — Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon and still emerging peripheral T cell lymphoma caused by and arising around textured-surface breast implants placed for either reconstructive or cosmetic indications. The association of breast implants with a cancer of the immune system has created understandable concern among patients,…

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A Primer in Biological Data Analysis and Visualization

With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data, the field of bioinformatics has made significant progress in the analysis and…

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Bioplastic (poly-3-hydroxybutyrate)-producing Massilia endophytica sp. nov., isolated from Cannabis sativa L. ‘Cheungsam’

Sample collection and bacterial isolation The strain DM-R-R2A-13T was obtained from a sample of Cannabis sativa in Andong, Republic of Korea. To isolate the strain, leaf samples (5.3 g) and root samples (6.3 g) were subjected to surface-sterilization using 1% sodium hypochlorite for 20 min followed by 70% ethanol for 10 s, and then…

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Entropy-driven reactions for controlling CRISPR/Cas12a and constructing an electrochemical biosensor for cardiac biomarkers detection

Lei Y-M, Xiao M-M, Li Y-T, Xu L, Zhang H, Zhang Z-Y et al (2017) Detection of heart failure-related biomarker in whole blood with graphene field effect transistor biosensor. Biosens Bioelectron 91:1–7 Article  CAS  PubMed  Google Scholar  Xin Y, Wang M, Liu M, Chen Y, Zhao H, Zhang P et…

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Analyzing CareDx (NASDAQ:CDNA) & Sonic Healthcare (OTCMKTS:SKHCF)

CareDx (NASDAQ:CDNA – Get Free Report) and Sonic Healthcare (OTCMKTS:SKHCF – Get Free Report) are both medical companies, but which is the better stock? We will contrast the two businesses based on the strength of their risk, dividends, profitability, earnings, valuation, institutional ownership and analyst recommendations. Institutional & Insider Ownership…

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Google’s Support for Generative AI Users in Copyright Conflicts

Google has adopted a robust stance aimed at safeguarding the interests of users who harness its generative artificial intelligence (AI) systems within the Google Cloud and Workspace ecosystems against potential allegations of intellectual property infringement. This move finds resonance with industry titans such as Microsoft and Adobe, both of which…

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Globally distributed Myxococcota with photosynthesis gene clusters illuminate the origin and evolution of a potentially chimeric lifestyle

Falkowski P. G., Raven J. A. Aquatic Photosynthesis (Princeton Univ. Press, 2013). Sanchez-Baracaldo, P., Bianchini, G., Wilson, J. D. & Knoll, A. H. Cyanobacteria and biogeochemical cycles through earth history. Trends Microbiol. 30, 143–157 (2022). Article  CAS  PubMed  Google Scholar  Blankenship, R. E. Early evolution of photosynthesis. Plant Physiol. 154,…

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Radiation Therapy and Irreversible Electroporation for Intermediate Risk Prostate Cancer (RTIRE)

Author links open overlay panelM. Diven 1, T.D. McClure 2, K. Ballman 3, A.E. Marciscano 4, C.E. Barbieri 5, H. Nagar 6 Show more doi.org/10.1016/j.ijrobp.2023.06.2485Get rights and content Purpose/Objective(s) The objective of the RTIRE clinical trial (NCT05345444) is to demonstrate the feasibility, safety, and early oncologic efficacy of combining MRI-guided…

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Tislelizumab vs Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Phase 3 Randomized Clinical Trial | Targeted and Immune Cancer Therapy | JAMA Oncology

Key Points Question  How does the efficacy and safety profile of tislelizumab compare with that of sorafenib as first-line treatment among patients with unresectable hepatocellular carcinoma (HCC)? Findings  In this phase 3 randomized clinical trial of 674 patients with HCC, tislelizumab demonstrated overall survival noninferiority compared with sorafenib, with numerically…

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A Guide to Noninvasive Methods

This transcript has been edited for clarity. Hi. I’m Michelle Kittleson. I’m a heart failure transplant cardiologist and professor of medicine at Cedars-Sinai in sunny Los Angeles, California. I’m delighted to have this opportunity to present a commentary on noninvasive surveillance for heart transplant rejection. As you may know, the…

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Radiomics Market Latest Survey Report 2023

PRESS RELEASE Published October 3, 2023 InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the “Global Radiomics Market Size, Share & Trends Analysis Report By Modality (Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron-Emission-Tomography (PET), Others), By Image Type (2D v/s 3D), By Technology (Engineered…

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Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

Peptide conjugation to trastuzumab A 23 amino acid peptide, acetyl-(Lys[Azide]) RRRGSGPDCAYHKGELVWCTFH-NH2, was chemically synthesized and modified with a succinimidyl glutarate linker at Lys14 (the numbering starts with Lys[Azide]) (Fig. 1A). To allow payload conjugation and increase the solubility of the conjugates, the N-terminus of the peptide was extended based on a…

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PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study | BMC Gastroenterology

Tissue samples A total of 84 analytic samples from surgical or biopsy specimens were collected from 84 patients who underwent radical surgery for CRC at Saitama Medical University International Medical Center between January and December 2016. One case was excluded because the specimen was too small; therefore, we used a…

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A CRISPR/Cas12a-SERS platform for amplification-free detection of African swine fever virus genes

African swine fever virus (ASFV) is a highly infectious and lethal agent in pigs and is classified as a “notifiable disease” by the World Organization for Animal Health (OIE) [1,2]. Although ASFV cannot infect humans, it is extremely difficult to prevent and control due to its multiple infection paths, which…

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A novel dsDNA decamer-based electrochemical biosensor for selective determination of irinotecan active metabolite – SN38,Sensors and Actuators B: Chemical

This paper presents a novel biosensor for detecting the active metabolite of irinotecan, SN38, with high selectivity and sensitivity. The biosensor utilizes a dsDNA decamer (5’-GCGTTGTCGC-3’) that selectively interacts with SN38. The biosensor, consisting of a screen-printed graphite electrode with the dsDNA decamer as the recognition layer, demonstrates stability, sensitivity,…

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Docking protocol – In silico Molecular Docking Protocol Using AutoDock Vina Prepared by: Jessa A.

In silico Molecular Docking Protocol Using AutoDock Vina Prepared by: Jessa A. Payusan Organic Synthesis Chemistry/Drug Design and Development Related Research Laboratory, Premier Research of Science and Mathematics, MSU-Iligan institute of Technology Iligan City, Philippines May 2020 Docking Protocol ii Table of Contents Page Title Page……………………………………………………………………………………………………………………… i – Introduction……………………………………………………………………………………………………… Table…

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Monomeric streptavidin phage display allows efficient immobilization of bacteriophages on magnetic particles for the capture, separation, and detection of bacteria

Zhou, Y., Marar, A., Kner, P. & Ramasamy, R. P. Charge-directed immobilization of bacteriophage on nanostructured electrode for whole-cell electrochemical biosensors. Anal. Chem. doi.org/10.1021/acs.analchem.6b03751 (2017). Article  PubMed  PubMed Central  Google Scholar  Bhardwaj, N., Bhardwaj, S. K., Mehta, J., Mohanta, G. C. & Deep, A. Bacteriophage immobilized graphene electrodes for impedimetric…

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Life Sciences Tools Market Size & Share to Surpass $328.1 Billion by 2030

Life Sciences Tools Market Size & Share to Surpass $328.1 Billion by 2030 | Vantage Market Research WASHINGTON, Sept. 22, 2023 (GLOBE NEWSWIRE) — As per Vantage Market Research, the Life Sciences Tools market has witnessed significant growth in recent years due to technological advancements and increasing investments in research…

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Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice

WDR6 is upregulated in response to insulin during insulin resistance We created an IR mouse model by feeding animals a HFD for 6 weeks20. Insulin injection was then performed (Fig. 1a). The phosphorylation of AKT, a key readout of the insulin signalling pathway21, showed decreased response to insulin, indicating resistance…

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Continued CRC Research Informs Later-Line Disease Management

Tumor placement and response to neoadjuvant chemotherapy can help clarify and personalize later-line colorectal cancer (CRC) treatment approaches, according to Howard S. Hochster, MD, FACP, who also emphasized the potential benefits of the paradigm’s expansion to include VEGF inhibitors, such as fruquintinib (HMPL-013). “[Later lines of therapy are] still areas…

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Reviewing Sonic Healthcare (OTCMKTS:SKHCF) and CareDx (NASDAQ:CDNA)

Sonic Healthcare (OTCMKTS:SKHCF – Get Free Report) and CareDx (NASDAQ:CDNA – Get Free Report) are both medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their earnings, valuation, profitability, analyst recommendations, dividends, institutional ownership and risk. Earnings and Valuation This…

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Single-cell screening of cerebral organoids to identify developmental defects in autism

In a recent study published in Nature, researchers develop the clustered regularly interspaced short palindromic repeats (CRISPR)-human organoids-single-cell ribonucleic acid (RNA) sequencing (CHOOSE) system to identify developmental brain defects in autism. Study: Single-cell brain organoid screening identifies developmental defects in autism. Image Credit: Yurchanka Siarhei / Shutterstock.com Diagnosing autism Autism spectrum disorder (ASD) is…

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Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation

Coronavirus disease (COVID-19) – World Health Organization. www.who.int/emergencies/diseases/novel-coronavirus-2019. Harvey, W. T. et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat. Rev. Microbiol. 19, 409–424 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  Kang, L. et al. A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation. Cell…

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Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy

This article details simultaneous electroencephalogram and functional magnetic resonance imaging (EEG-fMRI) recording procedures that can be used in both clinical and research settings. EEG processing procedures to remove imaging artifacts for clinical review are also included. This study focuses on the example of epilepsy during the interictal period. In this…

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AI-driven Insights into Protein Folding

Understanding Protein Folding: The Power of AlphaFold The field of protein folding has long been a mystery to scientists. Understanding how proteins fold into their three-dimensional structures is crucial for deciphering their functions and developing new drugs. For decades, researchers have been grappling with this complex problem, trying to unlock…

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Conjugation of microbial-derived gold nanoparticles to different types of nucleic acids: evaluation of transfection efficiency

AuNP production Fusarium oxysporum was used for the extracellular production of AuNP. The fungus was acquired from the Culture Collection of Fungi of the Charles University (CCF 3732, Czech Republic). After cultivation in Sabouraud Dextrose Broth (SDB, Sigma Aldrich, Prague, Czech Republic) at 30 °C and 150 rpm for 4 days, the supernatant…

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Hybridization chain reaction circuit controller: CRISPR/Cas12a conversion amplifier for miRNA-21 sensitive detection

MicroRNA (miRNA) acts as a biomarker, reflecting the occurrence and development of many diseases by regulating human metabolic pathways and gene expression regulating [[1], [2], [3], [4], [5]]. Consequently, miRNA has been studied in clinical diagnosis, treatment, prognosis and drug development [[6], [7], [8], [9]]. Particularly, miRNA-21 (miR-21) is one…

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KEGG ENZYME: 2.1.1.326

Entry EC 2.1.1.326                Enzyme                                  Name N-acetyldemethylphosphinothricin P-methyltransferase;phpK (gene name);bcpD (gene name);P-methylase Class Transferases;Transferring one-carbon groups;MethyltransferasesBRITE hierarchy Sysname S-adenosyl-L-methionine:N-acetyldemethylphosphinothricin P-methyltransferase Reaction(IUBMB) 2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5′-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:C00019]; N-acetyldemethylphosphinothricin [CPD:C17949]; reduced acceptor [CPD:C00030] Product S-adenosyl-L-homocysteine [CPD:C00021]; 5′-deoxyadenosine [CPD:C05198];…

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Analyzing Medical Imaging (OTCMKTS:MEDD) & CareDx (NASDAQ:CDNA)

Medical Imaging (OTCMKTS:MEDD – Get Free Report) and CareDx (NASDAQ:CDNA – Get Free Report) are both medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their valuation, risk, analyst recommendations, dividends, earnings, profitability and institutional ownership. Profitability This table compares…

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An aqueduct connecting the brain to the ear may make gene therapy for hearing loss less invasive.

Researchers restored hearing in mice with a gene therapy delivered via the cerebrospinal fluid. To hear a sound, auditory signals travel through a person’s ear, where they are transformed into vibrations that swirl through fluid in the cochlea, a spiral, snail-like structure in the inner ear. This fluid movement pushes…

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BridgeBio Pharma to Present Detailed Results from the Phase 3 ATTRibute Study in Patients with Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM) at European Society of Cardiology (ESC) Congress 2023

PALO ALTO, Calif., Aug. 24, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, announced today that detailed Phase 3 results from ATTRibute-CM, its study of acoramidis in transthyretin amyloid cardiomyopathy, or ATTR-CM, will be presented at…

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Common cold may have met its match with Firebrick Pharma nasal spray results looming

Firebrick Pharma may be just a month from proving its nasal spray – which has already proven effective against Covid-19 – can reduce the duration and severity of the common cold and prevent its spread. Firebrick (ASX:FRE) is eagerly awaiting results of its Phase 3 trial, which is due by…

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A pilot cohort study on infants with new-onset epilepsy examines the clinical utility of rapid genome sequencing

In a recent study published in the Lancet Neurology, researchers evaluated the clinical impact of rapid genome sequencing of infants with new-onset epilepsy using their biological parents as probands.  To this end, they performed a multicentre pilot cohort study of the International Precision Child Health Partnership (IPCHiP), a consortium of four…

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Gattermann Koch Reaction: Mechanism, Application, Limitation

Gattermann Koch reaction involves the reaction of benzene with CO and HCl in the presence of Lewis catalysts e.g., AlCl3 to form benzaldehyde. In 1897, L. Gattermann and J.A. Koch developed this reaction process. They successfully added an aldehyde group to toluene by using formyl chloride (HCOCl) and Lewis catalysts…

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Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

This is a video showing a modified laparoscopic anatomic hepatectomy, which involves the combination of CUSA and ultrasonic dissector in a two-surgeon technique, as well as a modified extracorporeal Pringle maneuver along with low central venous pressure technique. This is a 54-year-old female with the one-week history of liver mass,…

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Solved Consider this reaction: 1. \\( \\mathrm{AlCl}_{3} \\)

Transcribed image text: Consider this reaction: 1. \\( \\mathrm{AlCl}_{3} \\) 2. \\( \\mathrm{H}_{2} \\mathrm{O} \\) a) What is the electrophile in this reaction? b) Draw the resonance forms of the most stable intermediate. i.e. the one that leads to the major product. c) Is the product more reactive than the…

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Multiply Relapsed Secondary CNS Non-Germinal Center

Introduction Secondary central nervous system diffuse large B-cell lymphoma (SCNS-DLBCL) represents central nervous system (CNS) dissemination and involvement by a systemic DLBCL at the time of initial diagnosis (de novo SCNSL; DN-SCNSL) or relapse (R-SCNSL).1–6 R-SCNSL include CNS-only or concomitant CNS-systemic relapse. R-SCNSL develops early in the disease course with…

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Biochemistry in Everyday Life – Jammu Kashmir Latest News | Tourism

Dr Swati RajputBiochemistry merges biological sciences with chemistry to study living matter. It has a marvelous impact on scientific and medical discovery in fields such as food, pharmaceuticals, forensics, agriculture, genetic engineering, and many others. With biochemistry, chemical reactions at a molecular level can be better understood and new ways…

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Reply to: Antibiotics and hexagonal order in the bacterial outer membrane

replying to G. Benn et al. Nature Communications doi.org/10.1038/s41467-023-40275-0 (2023) Benn et al. comment that the hexagonal lattices observed in outer membrane (OM) patches upon the addition of polymyxin might be formed by outer membrane proteins (OMPs). They assume that lipopolysaccharides (LPS) protrude above the OMPs, which might hide the…

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Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia

Phylogenetic relationships within Salvia To characterize chemical diversity and phylogenetic relationships within the genus Salvia, 77 species, including six outgroups (Melissa officinalis L., Mentha spicata L., Clinopodium polycephalum (Vaniot) C.Y.Wu & S.J.Hsuan, Origanum vulgare L., Nepeta cataria L., and Prunella vulgaris L.), were sampled for analyses (Supplementary Data 1), covering the…

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Activation of cell-free mtDNA-TLR9 signaling mediates chronic stress-induced social behavior deficits

Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci. 2012;35:24–35. Article  CAS  PubMed  Google Scholar  Koenigs M, Grafman J. Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala. Neuroscientist. 2009;15:540–8. Article  PubMed  PubMed Central  Google Scholar  Nemeroff CB, Vale…

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Development of peptide nucleic acid-based bead array technology for Bacillus cereus detection

Zhang, Z. et al. Detection of viable enterotoxin-producing Bacillus cereus and analysis of toxigenicity from ready-to-eat foods and infant formula milk powder by multiplex PCR. J. Dairy Sci. 99, 1047–1055 (2016). Article  CAS  PubMed  Google Scholar  Rahnama, H., Azari, R., Hashem, M. & Berizi, E. A systematic review and meta-analysis…

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Chemically programmed STING-activating nano-liposomal vesicles improve anticancer immunity

Rational design of STING-activating pro-drugs for liposomal formulation A recently discovered non-nucleotide STING agonist, MSA-2, was selected to test the validity of our drug design. To facilitate the liposomal formulation of MSA-2, four synthetic MSA-2 derivatives (compounds 1–4) were initially constructed via ester bonds using MP-typed alkanols of varying lengths…

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Process development and scale-down in animal cell (CHO cell) culture

Background Animal cell cultivation in a lab scale experiment is not always directly transferable to industrial scale. Hence, the gap between lab scale and industry scale in normally bridged by 10 L bioreactor systems. However, the problem that has been realized is to model and analyse based on these 10…

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Primary Diffuse Large B-Cell Lymphoma of the Penis

Background Diffuse large B cell lymphoma (DLBCL) is the most common B lymphoid malignancy disorder, representing more than 30% of non-Hodgkin’s lymphoma.1 Although typical morphology is characterized by the diffuse or sheet-like proliferation of mature large B cells, DLBCL is a class of highly heterogeneous diseases exhibiting varying clinical and…

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is a breakthrough in sight?

Among the rarest forms of cancers, sarcomas develop in the bones and connective tissues that support structures in the body like blood vessels, nerves and joints. This year, around 13,400 new cases of soft tissue sarcomas are estimated to be diagnosed in the U.S. alone, according to the American Cancer…

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Self-primer exponential Cas12a tandem reaction-amplified and [Cu(tz)] nanosheets based neoteric biosensing platform for quantifying multiple mTBI-related miRNAs

Head injuries are a globally widespread problem, particularly among children and teenagers, who may be more susceptible to long-term sequelae during brain development. Concussion, a sign of mild traumatic brain injury (mTBI), affects an estimated 20% of teenagers [1], [2]. Unfortunately, due to delayed onset of symptoms and strong subjectivity…

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Fame | John M. Jumper net worth and salary income estimation Jul, 2023

How about John M. Jumper’s h_index? John M. Jumper H_index: 20 How about John M. Jumper’s education? John M. Jumper Education: The University of Chicago (2017), Vanderbilt University, University of Cambridge How about John M. Jumper’s awards? John M. Jumper Awards: Breakthrough Prize in Life Sciences (2023) What is the…

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Human EpCAM Matched Antibody Pair Set [ABP-S-021194]

Human EpCAM antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG (Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don’t need to select any button.) For Research Use Only. AgonistAgonist AntagonistAntagonist…

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Top Growing Industry Demand and Growth Opportunities, Leading Players and Growth Status Forecast by 2030

PRESS RELEASE Published July 18, 2023 The 2023 report on the “Linux Operating System Market” stands as a definitive and meticulous analysis, encompassing a wide range of factors affecting business growth opportunities, challenges, risk factors, and emerging trends across diverse geographical regions. This comprehensive report offers up-to-date and precise information…

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French startup revolutionizes early diagnosis of endometriosis

A condition that affects around 190 million women and girls worldwide, according to the World Health Organization, endometriosis is a chronic, difficult-to-treat disease that causes debilitating pelvic pain. Often misdiagnosed as irritable bowel syndrome (IBS) and sometimes dismissed as menstrual cramps, the diagnosis of endometriosis can take around 10 years,…

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LianBio Announces Phase 3 EXPLORER-CN Data Accepted for Late-Breaking Presentation at the European Society of Cardiology Congress 2023

SHANGHAI, China and PRINCETON, N.J., July 17, 2023 (GLOBE NEWSWIRE) — LianBio (Nasdaq: LIAN), a biotechnology company dedicated to bringing innovative medicines to patients in China and other major Asian markets, today announced data from the Phase 3 EXPLORER-CN trial of mavacamten in Chinese symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients…

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A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex

Abstract The signaling pathway of transforming growth factor-beta (TGFβ) plays crucial roles in the establishment of an immunosuppressive tumor microenvironment, making anti-TGFb; agents a significant area of interest in cancer immunotherapy. However, the clinical translation of current anti-TGFb; agents that target upstream cytokines and receptors remains challenging. Therefore, the development…

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The combined action of the intracellular regions regulates FGFR2 kinase activity

To provide structure and clarity to the understanding of the intricate control mechanism herein investigated, we have deconstructed intracellular FGFR2 to the three principle regulatory regions: JM, KD and CT. This provides an understanding of how both JM and CT influence KD activation and dimerization. Through subsequent reconstruction of their…

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Biologists publish new guidelines to facilitate data sharing of research on disordered proteins

For decades, structural biologists have been working on cracking the molecular 3D structures of proteins to understand their function. But what if a protein doesn’t have a fixed structure? For molecules that keep changing their shape all the time, both research and sharing the findings within the scientific community can…

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Positive Results Announced from Phase 3 OCARINA II Trial Evaluating Roche’s OCREVUS with Halozyme’s ENHANZE Drug Delivery Technology in Patients with Multiple Sclerosis

SAN DIEGO – Halozyme Therapeutics, Inc. (NASDAQ: HALO) (‘Halozyme‘) today announced that Roche’s Phase 3 OCARINA II trial evaluating OCREVUS with ENHANZE as a twice a year 10-minute subcutaneous (SC) injection, met its primary and secondary endpoints in patients with relapsing forms of multiple sclerosis (MS) or primary progressive MS…

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Halozyme Therapeutics (HALO) Reports Positive Data from Phase 3 OCARINA II Trial Evaluating Roche’s OCREVUS with ENHANZE

Halozyme Therapeutics, Inc. (NASDAQ: HALO) (“Halozyme“) today announced that Roche’s Phase 3 OCARINA II trial evaluating OCREVUS® (ocrelizumab) with ENHANZE® as a twice a year 10-minute subcutaneous (SC) injection, met its primary and secondary endpoints in patients with relapsing forms of multiple sclerosis (MS) or primary progressive MS (RMS or…

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Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function | BMC Medicine

Hill SK, Reilly JL, Keefe RS, Gold JM, Bishop JR, Gershon ES, Tamminga CA, Pearlson GD, Keshavan MS, Sweeney JA. Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. Am J Psychiatry. 2013;170(11):1275–84. PubMed  PubMed Central  Google Scholar  Penzes P, Cahill…

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Machine Learning and Structural Biology: A Powerful Partnership

Machine Learning and Structural Biology: A Powerful Partnership Machine learning and structural biology are two rapidly evolving fields that have been making significant strides in recent years. When combined, these two disciplines have the potential to revolutionize our understanding of the molecular mechanisms that underlie biological processes, as well as…

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