Tag: resonance

Simultaneous ultrasensitive ADP and ATP quantification based on CRISPR/Cas12a integrated ZIF-90@Ag3AuS2@Fe3O4 nanocomposites

doi: 10.1016/j.bios.2022.114784. Online ahead of print. Affiliations Expand Affiliations 1 Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; University of the Chinese Academy of Sciences, Beijing, 100039, China; Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine…

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The comprehensive detection of miRNA and circRNA in the regulation of intramuscular and subcutaneous adipose tissue of Laiwu pig

Zhou, G. et al. Global comparison of gene expression profiles between intramuscular and subcutaneous adipocytes of neonatal landrace pig using microarray. Meat. Sci. 86(2), 440–450 (2010). CAS  PubMed  Article  Google Scholar  Alfaia, C. M. et al. Current feeding strategies to improve pork intramuscular fat content and its nutritional quality. Adv….

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A causal association of ANKRD37 with human hippocampal volume

Lisman J, Buzsáki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20:1434–47. CAS  PubMed  PubMed Central  Article  Google Scholar  Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015;22:411–6. PubMed …

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Global iPSCs Manufacturing Services Market Research Insight 2022

Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell groups Ch1-3 and Ch4 (Nucleus Basalis of Meynert; NBM),…

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Intraoperative Ultrasound in Spinal Surgery

Here, we present a protocol on the use of intraoperative ultrasound in spinal surgery, particularly in cases of intradural lesions and lesions in the ventral spinal canal when using a posterior approach. Intraoperative ultrasound for spine surgery is very useful for intradural pathology or ventral spinal cord pathology that allow…

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Ablation Technologies Market Top Companies, Business Growth & Investment Opportunities

Rising incidences of symptoms such as cancer and cardiac ailments is expected to foster the demand for ablation procedures. Technological advancements to design high-end products and growing demand for treatment procedures, which are minimally invasive are expected to boost the ablation technologies market. Furthermore, rising count of aging population having…

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Metagenomics Sequencing Market Size 2022 Global Industry Revenue, Business Growth, Development Strategy, Trends, Demand and Applications Market Research Report Forecast 2025

Global “Metagenomics Sequencing Market” Research Report 2022 is a historical overview and in-depth study of the current & future market of the Metagenomics Sequencing industry. The report represents a basic overview of the Metagenomics Sequencing market share, and competitor segment with a basic introduction of key players, top regions with…

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Nature Depth: Where will this revolutionary technology go when artificial intelligence predicts protein structure?

▎ WuXi AppTec content team editor Last July, DeepMind published a study in the journal Nature on artificial intelligence (AI) systems AlphaFold predicting the three-dimensional structure of proteins based on amino acid sequences. The researchers also released the source code of the AI system, making this technology available to scientists…

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Label-Free Resonance Rayleigh Scattering Amplification for Lipopolysaccharide Detection and Logical Circuit by CRISPR/Cas12a-Driven Guanine Nanowire Assisted Non-Cross-Linking Hybridization Chain Reaction,Analytical Chemistry

Although the CRISPR/Cas system has pioneered a new generation of analytical techniques, there remain many challenges in developing a label-free, accurate, and reliable CRISPR/Cas-based assay for reporting the levels of low abundance biomolecules in complex biological samples. Here, we reported a novel CRISPR-derived resonance Rayleigh scattering (RRS) amplification strategy and…

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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

We present detailed protocols for the generation and characterization of 2D and 3D human induced pluripotent stem cell (hIPSC)-based models of neocortical development as well as complementary methodologies enabling qualitative and quantitative analysis of primary cilium (PC) biogenesis and function. The overall goal of the procedure we detail here is…

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Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

This protocol describes the surgical and technical procedures that enable real-time in vivo multiphoton fluorescence imaging of the rodent brain during focused ultrasound and microbubble treatments to increase blood-brain barrier permeability. Ultrasound exposure in the presence of microbubbles has emerged as an effective method to transiently and locally increase the…

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Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain

Submission history Received: 29 April 2019 Accepted: 26 January 2022 Acknowledgments We thank T. Yamane (Osaka City General Hospital), K. Koh (Osaka General Hospital for West Japan Railway Company), and M. Ichii (Osaka University Graduate School of Medicine) for MM samples; T. Kitamura (The University of Tokyo) for the retroviral…

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Alectinib Monotherapy in Isolated Central Nervous System Relapse of ALK-Positive Anaplastic Large Cell Lymphoma

Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK-positive ALCL) is an aggressive form of peripheral T cell lymphoma (PTCL), harbouring an underlying pathogenic ALK fusion gene that produces a constitutively activated tyrosine kinase. The ALK tyrosine kinase provides a targeted treatment option in the form of ALK inhibitors. ALK-positive ALCL…

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Clinical manifestations of diffuse large B-cell lymphoma that exhibits initial symptoms in the maxilla and mandible: a single-center retrospective study | BMC Oral Health

Table 1 summarizes the clinical findings at the initial examination. History of treatment before the initial examination Sixteen patients (59.3%) had previously undergone diagnosis and treatment of the site at a previous dental clinic or another Department of Oral Surgery prior to the initial examination at our department. Tooth extraction…

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Deciphering Protein Structure-Dynamics-Function Relationships in the Post AlphaFold Era

AI techniques have come of age – Google DeepMind’s AlphaFold, and other competitive approaches such as RosettaFold, and the more recent efforts at folding RNA structures using Atomic Rotationally Equivariant Scorer (ARES), have enabled accurate predictions of protein and RNA three-dimensional (3D) structures starting with just their primary sequences….

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Cost and clinical benefit of imaging surveillance after treatment for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)

Recent UK guidelines recommend that surveillance imaging should not be offered to patients who have undergone treatment for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) unless clinically indicated. The aim of this study was to explore the evolving practice at a tertiary referral unit and quantify the direct economic costs…

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miRNAs and mRNAs in intestinal ischemia-reperfusion injury

Introduction Intestinal ischemia-reperfusion (II/R) injury is a severe clinical complication common in the Intensive Care Unit (ICU). It is associated with high morbidity and mortality.1 Usually, this problem is followed by various causes, including sepsis, shock, trauma, and so on.2 Intestinal ischemia-reperfusion injury destroys intestinal tissue and impairs the function…

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Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer b

Introduction Prostate cancer (PCa) is one of the most common genitourinary system malignant tumor in men worldwide. In Asian countries, many patients with PCa are often diagnosed at an advanced stage maybe mostly because of a large population base with relatively backward economic development and imperfect cancer screening system of…

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Electroporation-mediated transcatheter arterial chemoembolization in the rabbit VX2 liver tumor model

Electroporation-mediated transcatheter arterial chemoembolization in the rabbit VX2 liver tumor model – Fingerprint — University of Texas Southwestern Medical Center Sort by Weight Alphabetically Medicine & Life Sciences Electroporation 100% Rabbits 59% Liver 43% Neoplasms 26% Cisplatin 20% Magnetic Resonance Imaging 15% Mass Spectrometry 13% Catheters 11% Cell Membrane Permeability…

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Combining CRISPR/Cas9 and brain imaging: from genes to proteins to networks

Abstract Understanding how functional connections between brain regions are arranged and influenced by genes, in the healthy and diseased states, is a major goal in neuroscience. Functional connectivity alterations are linked to molecular changes in several neurodegenerative disorders and could serve as early markers of pathology. Yet, the underlying molecular…

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Another breakthrough after AlphaFold!Challenge the problem of RNA structure prediction, new AI technology is coming

Determining the three-dimensional structure of biomolecules is one of the biggest challenges in modern biology. Traditionally, pharmaceutical companies and research institutions often spend millions of dollars to determine the structure of a molecule, but even with such a large investment, they often fail. AlphaFold on the cover of Nature magazine…

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Rare barley mutation with potential

Seven-day-old barley roots of mutant egt2: It grows strictly downwards (hypergravitropic). Credit: Gwendolyn Kirschner The importance of the root system for agricultural yields is often underestimated. Whether roots can access water and nutrients effectively also determines the resilience of important crops to drought and climate change. Researchers from the Universities…

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Nuclear protein in testis carcinoma

Introduction Nuclear protein in testis (NUT) carcinoma (NC) is defined by the rearrangement of the chromosomal region 15q14 harboring the NUTM1 gene. As a clinically aggressive neoplasm with poor differentiation, NC was previously believed to occur primarily in children and young adolescents. However, with an increasing number of reports, middle-aged…

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Focal therapy for localised prostate cancer

By Kalli Spencer The main goal of focal therapy is the targeted focal destruction of cancer tissue with the preservation of surrounding healthy prostate tissue. There have been conflicting opinions on the definition, but it seems the consensus is “ablation of the dominant or index lesion”1. The principle of targeted…

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Infective endocarditis caused by ESBL-EC

Tsuneaki Kenzaka,1,2 Yuto Shinkura,1 Shizuo Kayama,3– 5 Liansheng Yu,3– 5 Sayoko Kawakami,3 Motoyuki Sugai,3– 5 Satoru Kawasaki1 1Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tanba, Japan; 2Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Kobe, Japan; 3Antimicrobial Resistance Research Center, National Institute of…

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