Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis

Identification of CH cases from WGS in ISL and UKB We used WGS from 45,510 Icelanders and 130,709 British ancestry participants from the UKB17,18. Average sequencing depth was 33× for UKB and 38× for ISL. Participants with prior diagnoses of hematological disorders or grossly abnormal hematology measurements on entry were…

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Hi , im trying to preorm SKAT test (rdrr.io/cran/SKAT/man/SKAT.html) for every gene in my data . in order to do that for every gene i created the genetype matrix which has 21 rows ( as number of patients) and columns as number of SNPs for every gene . this is…

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Full-Time Research Assistant Professor

Position Description The Cruchaga Lab, member of the Neurogenomics and Informatics Center (NGI) at Washington University School of Medicine, invites applications for a faculty position at the rank of Research Assistant Professor to develop a project to identify novel genes and pathways in Alzheimer’s Disease utilizing Whole Genome Sequencing. The…

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Rvtests SKAT-O output

Rvtests SKAT-O output 0 Hi there, After running SKAT-O, the output has some columns that I would like to understand better: NumVar: number of variants in the gene (or site) NumPolyVar: number of Polymorphic Genotypes What’s the difference? Thank you rvtests sequencing SNP • 9 views Login before adding your…

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Rare variant association analysis (SKAT-O)

Hello everyone, I was wondering if it is statistically acceptable to perform SKAT-O analysis one a single gene. To elaborate, I am looking in a miRNA gene (80nt length) and I have found a small number of rare variants present in my case group, but none in my control group….

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