Tag: SMAD4

Short tandem repeat mutations regulate gene expression in colorectal cancer

A novel STR panel for human protein-coding genes To explore STR mutations in CRC, we first annotated STRs in the introns, exons, and promoter sequence of all protein-coding genes in the GRCh38 reference genome (“Methods”). We discarded STR loci for which genotyping was expected to be inaccurate due to genomic…

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SMAD4 variants and its genotype-phenotype correlations to juvenile polyposis syndrome

Abstract BACKGROUND: Juvenile polyposis syndrome (JPS), a rare autosomal dominant syndrome, affects one per 100 000 births, increasing lifetime cancer risk by 9 – 50%. Around 40-60% of JPS cases are caused by disease-causing variants (DCV) in SMAD4 or BMPR1A genes, of which SMAD4 accounts for 20-30%. OBJECTIVES: To characterise…

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SMAD4 (Pancreatic Adenocarcinoma Marker) – CloneID – rSMAD4/6310

SMAD4 (Pancreatic Adenocarcinoma Marker) – CloneID – rSMAD4/6310 | Scientist.com Skip to Main Content Go to Main Navigation Details Gene ID: 4089 Uniprot: Q13485 Gene Name: SMAD4 Applications: IHC Species Reactivity: Human, mouse, , rat Clonality: Monoclonal Host: Recombinant Mouse Clone ID: rSMAD4/6310 Protein Target: SMAD4 Supplied As: 200ug/ml of…

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Bioinformatics-based analysis of the relationship between disulfidptosis and prognosis and treatment response in pancreatic cancer

Identification of DRGs in PCa Figure 1a showed the flow chart of this study. To explore the role of DRGs in PCa, we analyzed the gene expression profiles of these 15 DRGs in PCa patients. As shown in Fig. 1b, for ACTN4, TLN1, IQGAP1, CD2AP, FLNA, MYH9, MYL6, and ACTB genes, the…

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Cancers | Free Full-Text | In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion

Original submission received: 21 November 2023 / Revised: 8 December 2023 / Accepted: 11 December 2023 / Published: 13 December 2023 Round 1 Reviewer 1 Report Comments and Suggestions for Authors Dear authors, thank you for this valuable piece of work. Should the other reviewer(s) recommend edits to your work,…

Continue Reading Cancers | Free Full-Text | In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion

Human Smad4 Antibody Pair – BSA and Azide free (ab241847)

Human Smad4 Antibody Pair – BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human Smad4. Alternative names= MADH4, MYHRS, Medea, SMAD4, Smad4, MADH 4, SMAD 4, hSMAD4, SMAD4_HUMAN, MAD homolog 4, OTTHUMP00000163548, SMAD family member 4, Mothers…

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Anti-Smad4 antibody [EPR22589-112] – BSA and Azide free (AB254290)

Rabbit Recombinant Monoclonal SMAD4 antibody. Carrier free. Validated in IP, WB, ICC/IF, Flow Cyt (Intra) and tested in Mouse, Human, Rat samples. Alternative names= MADH4, MYHRS, Medea, SMAD4, Smad4, MADH 4, SMAD 4, hSMAD4, SMAD4_HUMAN, MAD homolog 4, OTTHUMP00000163548, SMAD family member 4, Mothers against DPP homolog 4, SMA- and…

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NOTCH1 mutations predict superior outcomes, NSCLC

Introduction Lung cancer remains the leading cause of cancer-related mortality worldwide, and the majority are non-small-cell lung cancer (NSCLC).1,2 Genetic variation is a typical feature of NSCLC that drives cancer initiation and progression.3 Understanding the role of mutated genes in NSCLC is the basis of the development of novel treatment…

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How does SMAD4 contribute to ANG2 regulation in HHT patients?

Does the TGF-β/SMA pathway contribute to the development of knee osteoarthritis?3 answersThe TGF-β/Smad pathway has been shown to play a critical role in the development of knee osteoarthritis (OA). TGF-β signaling molecules, such as Smad2, Smad3, and Smad4, have been found to be upregulated in meniscus-progenitor-cells (MPCs) from less diseased…

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SMAD4 Rabbit Polyclonal Antibody Clinisciences

Product Data Applications WB Recommended Dilution WB: 1:500-1:3000 Reactivities Human, Mouse, Rat Host Rabbit Isotype IgG Clonality Polyclonal Immunogen The immunogen for anti-Smad4 Antibody: A synthesized peptide derived from human Smad4 Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store…

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30ul | Anti-SMAD4 Antibody Clinisciences

Description: Rabbit polyclonal antibody to SMAD4 Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SMAD4. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and…

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SMAD4 promotes formation of terminally differentiated CTLs that localize in the microvasculature of the lungs but are excluded from the lumen of the airways

Abstract Cytotoxic T lymphocytes (CTLs) circulate around the body searching for infected and transformed cells, that undergo apoptosis when lytic granules are delivered into the cytoplasm. To find pathogens that propagate in different tissues, naive CD8 T cells differentiate into heterogeneous populations of effector (TEFF) and memory CD8 T cells…

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22-59898-100 | Anti-SMAD4 antibody (400-450) {Biotin} Clinisciences

Post Translational Modifications Phosphorylated by PDPK1. Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling. Function In muscle physiology, plays a central…

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Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway

Backgound: Colorectal cancer (CRC) is a complex, multistep disease that arises from the interplay genetic mutations and epigenetic alterations. The histone H3K36 trimethyltransferase SET domain-containing 2 (SETD2), as an epigenetic signalling molecule, has a 5% mutation rate in CRC. SETD2 expression is decreased in the development of human CRC and…

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Biomedicines | Free Full-Text | Association between SMAD4 Mutations and GATA6 Expression in Paired Pancreatic Ductal Adenocarcinoma Tumor Specimens: Data from Two Independent Molecularly-Characterized Cohorts

1. Introduction Pancreatic ductal adenocarcinoma (PDAC) has one of the highest case-specific mortality rates of all cancers [1]. Although resection remains the only curative therapy for PDAC, improvements in long-term survival are attributable to advances in systemic treatment [2,3,4,5]. Currently, 5-fluorouracil-based (i.e., with irinotecan and oxaliplatin as FOLFIRINOX) or gemcitabine-based…

Continue Reading Biomedicines | Free Full-Text | Association between SMAD4 Mutations and GATA6 Expression in Paired Pancreatic Ductal Adenocarcinoma Tumor Specimens: Data from Two Independent Molecularly-Characterized Cohorts

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of rho and ROCK

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of rho and ROCK – Fingerprint — Johns Hopkins University Sort by Weight Alphabetically Medicine & Life Sciences Bone Morphogenetic Proteins 100% Colorectal Neoplasms 65% Neoplasm Metastasis 50% Bone Morphogenetic Protein Receptors 32% Podosomes 22% Cell…

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Is there a correlation between the expression of Myd88, SMAD4, GRB2, and MAPK4 genes in gastric cancer?

The provided information does not mention anything about the correlation between Myd88, GRB2, and MAPK4 genes in gastric cancer. The correlation between the expression of Myd88, SMAD4, GRB2, and MAPK4 genes in gastric cancer was not mentioned in the provided information. The provided information does not mention any correlation between…

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Are the genes Myd88, SMAD4, GRB2, MAPK4 significantly associated with gastric cancer?

The genes Myd88, SMAD4, GRB2, and MAPK4 are not mentioned in the provided text as being significantly associated with gastric cancer. The genes Myd88, SMAD4, GRB2, and MAPK4 were not mentioned in the text as being significantly associated with gastric cancer. No, the genes Myd88, SMAD4, GRB2, and MAPK4 are…

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Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations

Ethical statement Our research complies with all relevant ethical regulations, including the Declaration of Helsinki and has been approved by the Institutional Review Boards of University of Chicago, Duke University and the Alliance to Cure Cavernous Malformations. Cerebral cavernous malformation lesions All human CCM tissue specimens have been previously reported18,19…

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Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells | Cancer Research

Fasting-mimicking diet (FMD) is emerging as an effective dietary intervention with the potential to prolong life span in healthy people and boost antitumor immunity in patients with cancer. FMD refers to a medically designed fasting-like state that allows periodic consumption of a very-low-calorie and low-protein diet (1, 2). Compared with…

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What mutation in the SMAD4 gene can cause pancreatic cancer?

Mutations in the SMAD4 gene have been identified as a major driver of pancreatic carcinogenesis. The inactivation of SMAD4 is a hallmark of pancreatic and other gastrointestinal cancers and has been associated with metastatic disease. SMAD4 nonstop mutations, which convert stop codons to sense codons that extend transcription, have also…

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What is the role of SMAD4 gene in pancreatic cancer?

The role of the SMAD4 gene in pancreatic cancer is not mentioned in the provided text information. The role of SMAD4 gene in pancreatic cancer is still controversial, but it is associated with worse overall survival and metastasis. The role of the SMAD4 gene in pancreatic cancer is discussed in…

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SMAD4 Archives – NewEast Biosciences

SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-β signal transduction pathway, which negatively regulates growth of…

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SMAD4 loss predicts worse overall and distant metastasis-free survival in patients with resected pancreatic adenocarcinoma

Background: In select patients, pancreatic adenocarcinoma remains a local disease, yet there are no validated biomarkers to predict this behavior and who may benefit from aggressive local treatments. This study sought to determine if SMAD4 (mothers against decapentaplegic homolog 4) messenger RNA-sequencing (RNA-seq) expression is a robust method for predicting…

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Determining the functions of SMAD4 during development, wound healing and cancer

Title Determining the functions of SMAD4 during development, wound healing and cancer Creator Philip Owens : Oregon Health and Science University Date 2008 Content Type Dissertation Record Created 2023-06-29 Record ID 492 Degree Type Ph.D. School School of Medicine Department Department of Cell, Developmental and Cancer Biology DownloadsUnique DownloadsViewsUnique Views…

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Hereditary haemorrhagic telangiectasia and SMAD4 mutation in a patient with complex single ventricle heart disease | Cardiology in the Young

We report a case of hypoplastic left heart syndrome and with subsequent aortopathy and then found to have hereditary haemorrhagic telangiectasia/juvenile polyposis syndrome due to a germline SMAD4 pathologic variant. The patient’s staged palliation was complicated by the development of neoaortic aneurysms, arteriovenous malformations, and gastrointestinal bleeding thought to be…

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Hereditary haemorrhagic telangiectasia and SMAD4 mutation in a patient with complex single ventricle heart disease

doi: 10.1017/S104795112300344X. Online ahead of print. Madison A Grasty  1 , Constantine D Mavroudis  2 , Aaron G DeWitt  3 , Benjamin W Kozyak  3 , Peter Mamula  4 , Suzanne P MacFarland  5 , Muhammad A K Nuri  2 , Lindsay S Rogers  6 , Jonathan J Rome  6 , J William Gaynor  2 , David J Goldberg  7…

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[KD Validated] Smad4 Rabbit pAb-Polyclonal Antibodies

Western blot – [KD Validated] Smad4 Rabbit pAb (A21487) Western blot analysis of HCT116, using Smad4 Rabbit pAb antibody (A21487) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (RM00020).Exposure time: 30s. Western…

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Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects | Biomarker Research

The exploration of methylated biomarkers in plasma for pancreatic cancer is still in its early stages, and the number of studies conducted to date for this purpose is limited. Analysis of cfDNA methylation patterns in pancreatic cancer has been approached both at the whole genome level and by identifying and…

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FDA Grants Marketing Authorization to First DNA Test to Assess Genetic Predisposition to Select Cancers

The FDA has granted de novo marketing authorization for the Invitae Common Hereditary Cancers Panel, an in vitro diagnostic test designed to detect genetic variants associated with an elevated risk of developing certain types of cancer.1 Additionally, the panel could also help identify potential cancer-associated variants in patients who have…

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PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study | BMC Gastroenterology

Tissue samples A total of 84 analytic samples from surgical or biopsy specimens were collected from 84 patients who underwent radical surgery for CRC at Saitama Medical University International Medical Center between January and December 2016. One case was excluded because the specimen was too small; therefore, we used a…

Continue Reading PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study | BMC Gastroenterology

Effect of miR-18a-5p, miR-19a-3p, and miR-20a-5p on In Vitro Cardiomyocyte Differentiation of Human Endometrium Tissue-Derived Stem Cells Through Regulation of Smad4 Expression

Background: Smad4 regulates the expression of the genes required for heart homeostasis. Regarding the central role of microRNAs in cardiac biology, we investigated the expression of the three Smad4-targeting miRNAs, namely miR-18a-5p, miR-19a-3p, and miR-20a-5p, as well as Smad4 during differentiation of human endometrium-derived mesenchymal stem cells (hEMSCs) into cardiomyocytes…

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Products | Abnova

Product Description Rabbit monoclonal antibody raised against a human SMAD4 peptide using ARM Technology. Immunogen A synthetic peptide of human SMAD4 is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence. Library Construction Non-fusion antibody library from rabbit spleen (ARM Technology). Expression …

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Beauchamp honored at symposium highlighting basic research by surgeon scientists | VUMC Reporter

From left, Mark Evers, MD; Seth Carp, MD; Robert Coffey, MD; Carmen Solórzano, MD; J. Joshua Smith, MD, PhD; Naji N. Abumrad, MD; Steven Leach, MD; and Paula Marincola Smith, MD, PhD, pose for a photo during the R. Daniel Beauchamp Memorial Symposium at Vanderbilt University Medical Center. Not pictured,…

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CircBTBD7 inhibits adipogenesis via the miR-183/SMAD4 axis

Adipogenesis is a complex biological process. However, the regulatory mechanism of circRNAs in adipogenesis is still unclear. In this study, we identified a novel circRNA, circBTBD7, which was highly expressed in adipose tissue and peaked at two days after differentiation in bovine primary adipocytes. When circBTBD7 was knocked down in…

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The molecular consequences of SMAD4 inactivation in the context of colon cancer.

The intestinal epithelium – the cell wall that separates the intestinal tract from the rest of the body – is constantly renewed by intestinal stem cells that divide continuously. This process is under strict control to ensure that cell division and cell death are balanced, and that cells develop into…

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Smad4 Protein | Profiles RNS

“Smad4 Protein” is a descriptor in the National Library of Medicine’s controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. A signal transducing adaptor protein and tumor suppressor protein. It forms a complex…

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SMAD4 promotes somatic-germline contact during oocyte growth

Abstract Development of the oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth factor (TGFβ)…

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SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development

doi: 10.1002/dvdy.652. Online ahead of print. Affiliations Expand Affiliations 1 Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA. 2 Multidisciplinary PhD Program in Biomedical Sciences: Cell Biology, Neuroscience and Physiology Track, New Jersey Medical School, Rutgers Biomedical and…

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SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer

1. Introduction Lung cancer is the most common cancer globally, with 2.21 million cases in 2020 and over 1.8 million deaths from lung cancer, making it the most common cause of cancer-related deaths [1]. In China, the estimated age-standardized incidence rate of lung cancer is as high as 34.8 per…

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“Mouse Modeling of Pancreatic Ductal Adenocarcinoma (PDAC); Search for ” by Kyoko Kojima

Degree Name by School School of Medicine [MED]; Doctor of Philosophy (PhD) Abstract PDAC is a highly malignant neoplasm that carries a very poor prognosis. PDAC development is a multistage transformation process that involves multiple genetic alterations that include activation of EGFR/HER2 and KRAS, and loss-of-function mutations in INK4A/ARF, p53…

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Unraveling variant misclassification: Insights from ClinVar and HGMD databases

Cardiac Comprehensive Kit analyzes 292 genes and covers major inherited cardiovascular disorders.   Genes Tested AARS2, ABCA1, ABCC6, ABCC9, ABCG5, ABCG8, ACAD9, ACADVL, ACTA1, ACTA2, ACTC1, ACTN2, ACVR1, ACVR2B, ACVRL1, ADAMTS2, AFF4, AGK, AKAP9, AKT3, ALDH18A1, ALMS1, ALPK3, ANK2, ANKRD1, APOA5, APOB, APOE, ATP6V0A2, ATP6V1A, ATP6V1E1, B3GALT6, B4GALT7, BAG3, BGN,…

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Impact of Smad4 and p53 mutations on the prognosis of patients with pancreatic ductal adenocarcinoma undergoing chemotherapy

Background: This prospective cohort study evaluated the feasibility of using endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) samples for comprehensive mutational analysis of cancer-related genes using microtissues. Methods: Fifty patients with suspected pancreatic cancer presenting consecutively at the Kindai University Hospital between January 2018 and January 2019 were enrolled. Cancerous tissues from…

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Expression of Smad4 and Smad7 of BMP signaling pathway in oral squamous cell carcinoma

[1] Urist MR, DeLange RJ, Finerman GA. Bone cell differentiation and growth factors[J]. Science, 1983, 220(4598): 680-686.[2] Wen XZ, Miyake S, Akiyama Y, et al. BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells [J]. Biochem Biophys Res Commun, 2004, 316(1): 100-106.[3] Heikinheimo KA, Laine MA,…

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Innovative research on schistosomiasis-associ | EurekAlert!

image: Genomic landscape of schistosomiasis-associated colorectal cancer. (A) Genetic characteristics of the SA-CRC. The number of mutations, the tumor mutation burden, the estimated MSI scores, and the predicted number of neo-epitopes of each sample were present. (B) Mutational landscape of recurrently mutated genes in SA-CRCs. Red arrow corresponds to the known…

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Unique Genetic Insights Revolutionize SA-CRC Treatment

In a study published in the journal Genes & Diseases, researchers from Naval Medical University and Soochow University conducted an in-depth investigation into the genomic landscape of schistosomiasis-associated colorectal cancer (SA-CRC). By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at…

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Prenatal diagnosis of Myhre syndrome with a heterozygous pathogenic variant in SMAD4 gene presented with thick nuchal translucency and cardiac abnormalities

Case Reports doi: 10.1002/pd.6414. Online ahead of print. Affiliations Expand Affiliations 1 Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, Hong Kong. 2 Department of Health, Clinical Genetic Service, Hong Kong, Hong Kong. 3 Prenatal Diagnostic Laboratory, Tsan Yuk Hospital, Hong Kong, Hong Kong. 4 Department of Paediatrics…

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Phenotypes for Smad4 MGI:3819927 MGI Mouse

Phenotypes Associated with This Genotype Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Smad4tm1.1Rob mutation (0 available); any Smad4 mutation (36 available) Smad4tm2.1Rob mutation (0 available); any Smad4 mutation (36 available) Read more here: Source link

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A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex

Abstract The signaling pathway of transforming growth factor-beta (TGFβ) plays crucial roles in the establishment of an immunosuppressive tumor microenvironment, making anti-TGFb; agents a significant area of interest in cancer immunotherapy. However, the clinical translation of current anti-TGFb; agents that target upstream cytokines and receptors remains challenging. Therefore, the development…

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Smad2 and Smad4 gene mutations in hepatocellular carcinoma

TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4…

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Methylation status, mRNA and protein expression of the SMAD4 gene in patients with non-melanocytic skin cancers

Background: SMAD4 is a potent tumor suppressor. SMAD4 loss increases genomic instability and plays a critical role in the DNA damage response that leads to skin cancer development. We aimed to investigate SMAD4 methylation effects on mRNA and protein expression of SMAD4 in cancer and healthy tissues from patients with…

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Uterine defects and estradiol-dependent development of oviductal diverticula in mice lacking the SMAD4 C-terminal Mad homology 2 domain

doi: 10.1096/fj.202300737R. Affiliations Expand Affiliations 1 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S1085, Rennes, France. 2 Univ Paris-Sud, Inserm, UMR_S0782, Clamart, France. 3 Faculty of Health Sciences, University of Macau, Macau SAR, China. Item in Clipboard Fabrice G Petit et al. FASEB J….

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Post-operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui…

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Whole genome sequencing and disease pattern in patients with juvenile polyposis syndrome: a nationwide study

This study is a nationwide study including all 66 Danish patients who fulfilled the clinical criteria of JPS and/or had a PV in SMAD4 or BMPR1A. We found that almost 90% of patients with a clinical diagnosis of JPS had a PV in either BMPR1A or SMAD4. Endoscopy had been…

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MiR-210-5p promotes the differentiation of human induced pluripotent stem cells into dopaminergic neural precursors by targeting SMAD4 and SUFU and treats parkinsonian rats

doi: 10.1016/j.exger.2023.112243. Online ahead of print. Affiliations Expand Affiliations 1 Key Laboratory of Neurological Function and Health & Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China. 2 Department of Pediatrics, University of California-Irvine, Irvine, CA 92697, USA. 3 Key Laboratory of Neurological…

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SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis

Mice Senp2f/f mice were described as previously16. T cell-specific Senp2 knockout mice (CKO, Senp2f/fLckCre+/+) and control mice (WT, LckCre+/+) in C57BL/6 genetic background were raised and kept in the Academia Sinica SPF animal facility, according to the rule of the Animal Protection Act of Taiwan. Lck-Cre mice, Rag2−/− mice and CD45.1…

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FIGURE 8. Reduction of neural markers in Smad4…

FIGURE 8. Reduction of neural markers in Smad4β morphant embryos is associated with reduction of mesodermal genes. A single blastomere injection of 20 ng of Smad4β-MO with the lineage tracer nuclear β-galactosidase at the two-cell stage resulted in suppression of the muscle…

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Cloning and Bioinformaton Analysis of cDNA Encoding Cattle Smad4 Gene

[1] ZHAO Xueliang, WANG Shuyi, SUN Ke, SU Qian, WANG Wenlong, LIU Chunxia. Comparative Transcriptome Analysis of Albendazole-susceptible and Resistant Strains of Haemonchus contortus by RNA-Seq [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(9): 1940-1944. [2] YU Yan,…

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smad4 (SMAD family member 4 ) gene expression i…

smad4 (SMAD family member 4 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 31, lateral view, anterior left, dorsal up. This image is extracted from figure published in: Masuyama N et al. (1999), Image published in: Masuyama N et al. (1999) Copyright…

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SMAD4 Sequence Analysis (Prenatal Sequence Analysis) – Clinical test – NIH Genetic Testing Registry (GTR)

Overview Test order codeHelpLaboratory’s order or catalog code for the test (used in the order requisition form).: 22827 SMAD4 Sequence Analysis (Prenatal Sequence Analysis) This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis Loading data …… Click Indication tab for more information. Not provided…

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SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) patients are at special risk of suffering atherosclerosis, leading to major cardiovascular diseases. Notably, the transforming growth factor (TGF-β) plays a crucial role in the development and progression of atherosclerosis. In this context, the central regulator of TGF-β pathway, SMAD4 (small mother against decapentaplegic homolog 4),…

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SMAD4 orthologs – NCBI

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then…

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CircRNAs: versatile players and new targets in organ fibrosis | Cell Communication and Signaling

Organ fibrosis is the final common pathological pathway of many chronic diseases and is characterized by various injuries and insults with maladaptive tissue repair, followed by excessive collagen deposition into the extracellular matrix (ECM). Structural alterations lead to tissue stiffness, vascular rarefaction, hypoxia, proliferation, differentiation and activation of fibroblasts and…

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IJMS | Free Full-Text | SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea

MDPI and ACS Style Díaz-García, E.; García-Sánchez, A.; Sánz-Rubio, D.; Alfaro, E.; López-Fernández, C.; Casitas, R.; Mañas Baena, E.; Cano-Pumarega, I.; Cubero, P.; Marin-Oto, M.; López-Collazo, E.; Marin, J.M.; García-Río, F.; Cubillos-Zapata, C. SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea….

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[1, 25-(OH)2-VitD3 attenuates renal tubulointerstitial fibrosis in diabetic kidney disease by inhibiting Snail1-SMAD3/SMAD4 complex formation]

Objective To investigate the effect of 1, 25-(OH)2-VitD3 (VitD3) on renal tubuleinterstitial fibrosis in diabetic kidney disease. Methods NRK-52E renal tubular epithelial cells were divided into control group (5.5 mmol/L glucose medium treatment), high glucose group (25 mmol/L glucose medium treatment) and high glucose with added VitD3 group (25 mmol/L…

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Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma

Multi-omics analyses of the ICC samples Following multiregional sampling of primary ICC cases, we performed multi-omics analyses, including genome, transcriptome, proteome, and metabolome analysis. We used 10 (67 samples), 11 (88 samples), 10 (49 samples) and 10 (49 samples) ICC cases for WES, whole-transcriptome sequencing, proteomic analysis, and metabolomic analysis,…

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A Second Family with Myhre Syndrome Caused by the Same Recurrent SMAD4 Pathogenic Variation (p.Arg496Cys)

Introduction: Myhre syndrome (MS; OMIM #139210) is a rare connective tissue disorder presenting with cardiovascular, respiratory, gastrointestinal, and skeletal system findings. Fewer than 100 patients were reported until recently, and all molecularly confirmed cases had de novo heterozygous gain-of-function mutations in the SMAD4 gene. Dysregulation of the TGF-beta signaling pathway…

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Molecular Image Detail

Image Caption Generation of the Smad4tm2.1Cxd allele. Schematic diagram of the floxed Smad4 allele pre (Smad4tm2.1Cxd) and post-Cre-mediated recombination. A 234-bp fragment could be amplified from the deleted Smad4 allele by PCR using primers 1 and 2 (P1/P2) after the Cre-mediated excision of exon 8 of Smad4, and a 2.5-kb…

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SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS

. 2023 Apr;27(8):1045-1055. doi: 10.1111/jcmm.17216. Epub 2023 Mar 14. Affiliations Expand Affiliations 1 Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China. 2 Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. 3 Department of Plastic Surgery, The…

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All Phenotypes Tg(Dppa3-cre/Esr1*)3Sait MGI Mouse

Phenotypes associated with this allele Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (35 available) Tg(Dppa3-cre/Esr1*)3Sait mutation (0 available) reproductive system • following tamoxifen treatment at E10.5-E11.5, some male germ cells abnormally enter meiosis at E14.5 Read more here: Source…

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Expression and significance of Smad4 and p21WAF1 in endometrial carcinoma

Grau AM, Zhang L, Wang W, et al. Induction of p21WAF1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells [J]. Cancer Res 1997; 57:3929. PubMed  CAS  Google Scholar  Wilentz RE, Su GH, Dai JL, et al. Immunohistochemical labeling…

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IJMS | Free Full-Text | Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis

1. Introduction Endometriosis is one of the most common gynecological diseases, affecting 5–10% of women of reproductive age [1]. It is characterized by the presence of endometrial-like tissue outside the uterine cavity, which is manifested by chronic pelvic pain and/or infertility in 35–50% of women [2,3,4]. The course of this…

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Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan PMID: 31932471

Deciphering molecular targets to enhance sensitivity to chemotherapy is becoming a priority for effectively treating cancers. Loss of function mutations of SMAD4 in colon Cancer are associated with metastatic progression and resistance to 5-fluorouracil (5-FU), the most extensively used drug of almost all chemotherapy combinations used in the treatment of…

Continue Reading Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan PMID: 31932471

Pancreatic adenocarcinomas without KRAS, TP53, CDKN2A and SMAD4 mutations and CDKN2A/CDKN2B copy number alterations: a review of the genomic landscape to unveil therapeutic avenues

Background: Pancreatic adenocarcinoma is one of the cancers with the worst prognosis. The current treatment paradigm based on combination chemotherapy has improved survival over the last decade, but the disease is still fatal in most cases. New therapies exploiting the increasing understanding of the molecular pathology of the disease are…

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SMAD4: A Critical Regulator of Cardiac Neural Crest Cell Fate and Vascular Smooth Muscle Differentiation

Abstract Background: The pharyngeal arch arteries (PAAs) are precursor vessels which remodel into the aortic arch arteries (AAAs) during embryonic cardiovascular development. Cardiac neural crest cells (NCs) populate the PAAs and differentiate into vascular smooth muscle cells (vSMCs), which is critical for successful PAA-to-AAA remodeling. SMAD4, the central mediator of…

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SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration

Identification of TGFβ signaling pathway mutations in endometrial cancer We profiled the data from uterine tumors deposited to the cBioPortal of Cancer Genomics for mutations of the TGFβ signaling pathway20,21 and identified several mutations in TGFβ-related receptors (TGFBR1, TGFBR2, ACVR1B, ACVR1C, ACVR2A, ACVR2B) and transcription factors (SMAD2, SMAD3, SMAD4) (Supplementary…

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A case report of adult juvenile polyposis syndrome with SMAD4 pathogenic variant

1 Introduction Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder that is a type of hamartomatous polyp syndrome, and its incidence rate is approximately 1/100000 (1). The main clinical feature is the presence of multiple juvenile polyps in the gastrointestinal tract, most often in the colorectal (98%) but…

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Protein Partnership Curbs Growth of Pancreatic Cancer

Register for FREE to listen to this article Thank you. Listen to this article using the player above. ✖ Want to listen to this article for FREE? Complete the form below to unlock access to ALL audio articles. Scientists at VCU Massey Cancer Center uncovered a previously…

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Anti-Smad4 antibody KO Tested (ab110175)

Overview Product name Description Rabbit polyclonal to Smad4 Host species Rabbit Tested applications Species reactivity Reacts with: HumanPredicted to work with: Mouse, Rat, Sheep, Horse, Cow, Dog, Pig, Chimpanzee,…

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Recombinant Anti-Smad4 antibody [SP306] – C-terminal (ab217267)

Overview Product name Description Rabbit monoclonal [SP306] to Smad4 – C-terminal Host species Rabbit Tested applications Species reactivity Reacts with: Mouse, Rat, Human Immunogen Synthetic…

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(PDF) Chromosomal translocation disrupting the SMAD4 gene resulting in the combined phenotype of Juvenile polyposis syndrome and Hereditary Hemorrhagic Telangiectasia | Martin Larsen

(PDF) Chromosomal translocation disrupting the SMAD4 gene resulting in the combined phenotype of Juvenile polyposis syndrome and Hereditary Hemorrhagic Telangiectasia | Martin Larsen – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through…

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Protein partnership effectively fends off pancreatic cancer progression

Model for the functional interaction between Smad4 and Prdm16 during PDAC formation and progression. Credit: Journal of Cell Biology (2023). DOI: 10.1083/jcb.202203036 Scientists at VCU Massey Cancer Center have uncovered a previously unrecognized relationship between two sets of proteins that operate in tandem to fend off the growth of pancreatic…

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Recombinant Anti-Smad4 antibody [EP618Y] KO Tested (ab40759)

Overview Product name Description Rabbit monoclonal [EP618Y] to Smad4 Host species Rabbit Tested applications Suitable for: WB, IHC-Pmore detailsUnsuitable for: Flow Cyt,ICC/IF or IP Species reactivity Reacts with: Mouse,…

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Growth Control of Normal and Malignant Keratinocytes

Since this grant was first funded in 1985, it has been our goal to understand the molecular and cellular pathology of squamous cell cancers (SCC) of the aerodigestive tract, with the intent to develop novel molecular diagnostic, prognostic as well as therapeutic tools to improve the outcome of patients with…

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SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer

. 2021 Apr;101(4):463-476. doi: 10.1038/s41374-020-00517-x. Epub 2023 Jan 4. Affiliations Expand Affiliations 1 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 2 Department of Pathology, Shanghai First People’s Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China….

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ncRNA | Free Full-Text | LncRNA MALAT1 Regulates Hyperglycemia Induced EMT in Keratinocyte via miR-205

Non-Coding RNA 2023, 9(1), 14; doi.org/10.3390/ncrna9010014 (registering DOI) Non-Coding RNA 2023, 9(1), 14; doi.org/10.3390/ncrna9010014 (registering DOI) Received: 8 December 2022 / Revised: 31 January 2023 / Accepted: 9 February 2023 / Published: 11 February 2023 Round 1 Reviewer 1 Report The authors present a novel mechanism by which MALAT1 promotes EMT in…

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Comparison of the mutation patterns between tumor tissue and cell-free DNA in stage IV gastric cancer

Clinicopathological characteristics The clinicopathological features of the 56 stage IV GC patients are shown in Table 1. There were 29 males and 27 females. The mean age was 65.8 years old. The tumor was located mostly in the middle third of the stomach. Approximately 69.6% of the 56 patients had…

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Recombinant Human SMAD4 SMAD4-31193TH – Creative BioMart

Cat.No. : SMAD4-31193TH Optional Service: Optional requirements on this protein Product Overview : Recombinant full length human Smad4 with N-terminal proprietary tag; amino acids 1-552, 95kDa. Description : This gene encodes a member of the Smad family of…

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SMAD4, MSX HU, 100UG | Merck Life Science Indonesia

SMAD4, MSX HU, 100UG | Merck Life Science Indonesia The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure…

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circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma

Abstract Circular RNAs have been reported to be widely involved in cancer cell tumorigenesis and drug resistance; here, the aim of this study was to investigate whether circRNA Integrin Subunit Alpha 7 (ITGA7) (circ_ITGA7) was associated with the tumor growth and radiosensitivity of colorectal cancer (CRC). We found that circ_ITGA7…

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Smad4 Targeted Allele Detail MGI Mouse (MGI:3819836)

Smad4tm2.1RobTargeted Allele Detail Symbol: Smad4tm2.1Rob Name: SMAD family member 4; targeted mutation 2.1, Elizabeth J Robertson MGI ID: MGI:3819836 Synonyms: Smad4deltaNES Gene: Smad4  Location: Chr18:73772080-73836851 bp, – strand  Genetic Position: Chr18, 49.51 cM Alliance: Smad4tm2.1Rob page Germline Transmission:  Earliest citation of germline transmission: J:141589 Parent Cell Line:  CCE/EK.CCE (ES Cell) Strain of…

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Oncogenic Variants Identified in ~10 Percent With Appendix Cancer

TUESDAY, Nov. 22, 2022 (HealthDay News) — About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in JAMA Oncology. Andreana N. Holowatyj, Ph.D., from the Vanderbilt…

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NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) AND Hereditary cancer-predisposing syndrome – ClinVar

NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) AND Hereditary cancer-predisposing syndrome Based on: 1 submission [Details] Record status: current Accession: RCV001012497.1 Allele description [Variation Report for NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr)] NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) Gene: SMAD4:SMAD family member 4 [Gene – OMIM – HGNC] Variant type: single nucleotide variant Cytogenetic location: 18q21.2 Genomic location: Preferred name: NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) HGVS:…

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Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification

doi: 10.1002/kjm2.12574. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China. Item in Clipboard Yi Yu et al. Kaohsiung J Med Sci. 2022. Show…

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Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells – Hou

Introduction Pancreatic cancer (PC) is one of the most aggressive and lethal cancers (1). Previous studies have shown that aging, environmental and behavioral changes are more closely related to the dramatic increase in the incidence of PC worldwide than genetic factors (2–5). A position paper published by the European Federation…

Continue Reading Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells – Hou

SMAD4 rs10502913 | COPD

1Department of Pulmonary and Critical Care Medicine, Sinopharm Tongmei General Hospital, Datong, People’s Republic of China; 2China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Emergency, Chinese PLA General Hospital -Fourth Medical Center, Beijing, People’s Republic of China; 4School…

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BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility

Introduction Oocyte competence and quality depend on communication between the oocyte and the cumulus and theca cells. In the preantral phase, the members of the transforming growth factor β (TGF-β) superfamily are responsible for this communication and play an important role in folliculogenesis. Members of the TGF-β superfamily are related…

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Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer

Purpose: Hepatitis B virus (HBV) plays a crucial role in the progression of hepatocellular carcinoma (HCC). It is known that HBV-encoded X protein (HBx) can induce genetic alterations in some oncogenes and that SMAD4 is relevant for the development of some cancers, especially HBV-related HCC. Previously, it has been reported…

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AlphaLISA SureFire Ultra Human and Mouse Total SMAD4 Detection Kit, 50,000 Assay Points

check quantity false For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006). Request More Information Buy Now Add…

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