Tag: SMAD4

Oncogenic Variants Identified in ~10 Percent With Appendix Cancer

TUESDAY, Nov. 22, 2022 (HealthDay News) — About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in JAMA Oncology. Andreana N. Holowatyj, Ph.D., from the Vanderbilt…

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NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) AND Hereditary cancer-predisposing syndrome – ClinVar

NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) AND Hereditary cancer-predisposing syndrome Based on: 1 submission [Details] Record status: current Accession: RCV001012497.1 Allele description [Variation Report for NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr)] NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) Gene: SMAD4:SMAD family member 4 [Gene – OMIM – HGNC] Variant type: single nucleotide variant Cytogenetic location: 18q21.2 Genomic location: Preferred name: NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) HGVS:…

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Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification

doi: 10.1002/kjm2.12574. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China. Item in Clipboard Yi Yu et al. Kaohsiung J Med Sci. 2022. Show…

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Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells – Hou

Introduction Pancreatic cancer (PC) is one of the most aggressive and lethal cancers (1). Previous studies have shown that aging, environmental and behavioral changes are more closely related to the dramatic increase in the incidence of PC worldwide than genetic factors (2–5). A position paper published by the European Federation…

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SMAD4 rs10502913 | COPD

1Department of Pulmonary and Critical Care Medicine, Sinopharm Tongmei General Hospital, Datong, People’s Republic of China; 2China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Emergency, Chinese PLA General Hospital -Fourth Medical Center, Beijing, People’s Republic of China; 4School…

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BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility

Introduction Oocyte competence and quality depend on communication between the oocyte and the cumulus and theca cells. In the preantral phase, the members of the transforming growth factor β (TGF-β) superfamily are responsible for this communication and play an important role in folliculogenesis. Members of the TGF-β superfamily are related…

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Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer

Purpose: Hepatitis B virus (HBV) plays a crucial role in the progression of hepatocellular carcinoma (HCC). It is known that HBV-encoded X protein (HBx) can induce genetic alterations in some oncogenes and that SMAD4 is relevant for the development of some cancers, especially HBV-related HCC. Previously, it has been reported…

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AlphaLISA SureFire Ultra Human and Mouse Total SMAD4 Detection Kit, 50,000 Assay Points

check quantity false For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006). Request More Information Buy Now Add…

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1. What gene did you choose? (SMAD4, BMP2, BMPR1A,

Transcribed image text: 1. What gene did you choose? (SMAD4, BMP2, BMPR1A, BMPR1B, FBN1) FBN1 2. Describe the type of mutation (aberration) in your gene? Marfan syndrome 3. Is your assigned protein (DNA-mRNA-protein) a ligand, receptor, relay molecule, or structural protein? Structural protein Transduction 1. Signaling pathways may use mediators…

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SMAD4 antibody | Axil Scientific

This website uses cookies to ensure the best experience. By continuing, you agree to our privacy policy. × Product successfully added to quote! × There are items in your quote. Brand: Reference GTX03325 Brand GeneTex Application IHC-P Storage Conditions Store as concentrated solution. Centrifuge briefly prior to opening vial. Store…

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Genomic Stratification of Resectable CRLM Patients & Implications for Adjuvant Therapy and Survival

For a study, the researchers sought to see if genomic risk groups discovered by colorectal liver metastasis (CRLM) somatic mutation testing may be used for “molecularly-guided” adjuvant systemic chemotherapy and hepatic artery infusion of FUDR (SYS+HAI-FUDR). A prospective institutional database was analyzed for consecutive patients with resected CRLM and available…

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Pandas merge rows with different operations for each column

import pandas as pd df = pd.DataFrame({‘case_id’:[‘1’, ‘1’, ‘1’,’2′,’2′,’2′], ‘Gene’:[‘KRAS’,’SMAD4′,’TP53′,’TP000′,’SMAD000′,’TP000′], ‘ch_a’:[0,1,0,0,0,0], ‘ch_b’:[0,0,0,1,1,0], ‘ch_c’:[0,0,0,1,1,0]}) case_id Gene ch_a ch_b ch_c 0 1 KRAS 0 0 0 1 1 SMAD4 1 0 0 2 1 TP53 0 0 0 3 2 TP000 0 1 1 4 2 SMAD000 0 1 1 5 2…

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Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4

Introduction Hepatic fibrosis (HF) is a pathological phenomenon produced in the process of long-term damage and repair in the liver [1,2]. During the formation of HF, hepatocytes are damaged by various factors, such as chronic liver disease, and excessive intake of alcohol, and secrete a variety of cytokines [3]. Subsequently,…

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Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation

This article was originally published here Case Rep Pathol. 2022 Feb 8;2022:2640456. doi: 10.1155/2022/2640456. eCollection 2022. ABSTRACT Colorectal carcinoma with noncohesive tumor cells has been described in tumors with signet ring cells (mucinous adenocarcinoma and signet ring cell adenocarcinoma) and rhabdoid feature (carcinoma with sarcomatoid component). Cases of carcinoma with…

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Carcinogenesis: important findings on intrace

image: Stained liver tissue shows the complementary occurrence of pVHL and SMAD proteins: Where pVHL (green) is abundant, SMAD2/3 (red) is scarce, and vice versa. Cell nuclei are stained blue. The lower right picture shows all three colours combined. Photos: Xinglai Cheng/Goethe University view more  Credit: Xinglai Cheng/Goethe University FRANKFURT/HEIDELBERG. Signal…

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Characterization of Blood- Based Molecular Profiling in Pancreatic Adenocarcinoma

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

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MicroRNA-181a Deficiency Results in Transcriptome-Wide Cell-Specific Changes in The Kidney and Increases Blood Pressure

The micro ribonucleic acid (microRNA) [MiR-181a] is downregulated in the kidneys of rodents and patients suffering from high blood pressure (BP). The miR-181a is a posttranslational inhibitor of renin articulation in vitro, yet pleiotropic systems by which miR-181a may impact BP are unclear. Whether cancellation of miR-181a/b-1 in vivo changes…

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IRE combined with toripalimab versus IRE alone for LAPC

Introduction Pancreatic ductal adenocarcinoma (PDAC) is a lethal gastrointestinal disease with increasing morbidity, which also has a growing impact on cancer-specific mortality worldwide.1 Nearly 40% of all PDAC cases are localized to the pancreas and characterized with the involvement of major vascular structures, leading to unresectable disease without metastases detected…

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Prognostic Biomarkers Identified for Pancreatic Ductal Adenocarcinoma Using Whole Genome Sequencing

Possible biomarkers for prognosis and clinical outcomes were identified, through the use whole exome sequencing and RNA sequencing, as therapeutic targets for patients with pancreatic ductal adenocarcinoma (PDAC), according to a recent study. The study, published in Therapeutic Advances in Medical Oncology, also reconfirmed genomic landscapes, major driver mutations, and…

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