Tag: SMAD4

Background: Smad4 regulates the expression of the genes required for heart homeostasis. Regarding the central role of microRNAs in cardiac biology, we investigated the expression of the three Smad4-targeting miRNAs, namely miR-18a-5p, miR-19a-3p, and miR-20a-5p, as well as Smad4 during differentiation of human endometrium-derived mesenchymal stem cells (hEMSCs) into cardiomyocytes…

Product Description Rabbit monoclonal antibody raised against a human SMAD4 peptide using ARM Technology. Immunogen A synthetic peptide of human SMAD4 is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence. Library Construction Non-fusion antibody library from rabbit spleen (ARM Technology). Expression …

From left, Mark Evers, MD; Seth Carp, MD; Robert Coffey, MD; Carmen Solórzano, MD; J. Joshua Smith, MD, PhD; Naji N. Abumrad, MD; Steven Leach, MD; and Paula Marincola Smith, MD, PhD, pose for a photo during the R. Daniel Beauchamp Memorial Symposium at Vanderbilt University Medical Center. Not pictured,…

Adipogenesis is a complex biological process. However, the regulatory mechanism of circRNAs in adipogenesis is still unclear. In this study, we identified a novel circRNA, circBTBD7, which was highly expressed in adipose tissue and peaked at two days after differentiation in bovine primary adipocytes. When circBTBD7 was knocked down in…

The intestinal epithelium – the cell wall that separates the intestinal tract from the rest of the body – is constantly renewed by intestinal stem cells that divide continuously. This process is under strict control to ensure that cell division and cell death are balanced, and that cells develop into…

“Smad4 Protein” is a descriptor in the National Library of Medicine’s controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. A signal transducing adaptor protein and tumor suppressor protein. It forms a complex…

Abstract Development of the oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth factor (TGFβ)…

doi: 10.1002/dvdy.652. Online ahead of print. Affiliations Expand Affiliations 1 Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA. 2 Multidisciplinary PhD Program in Biomedical Sciences: Cell Biology, Neuroscience and Physiology Track, New Jersey Medical School, Rutgers Biomedical and…

1. Introduction Lung cancer is the most common cancer globally, with 2.21 million cases in 2020 and over 1.8 million deaths from lung cancer, making it the most common cause of cancer-related deaths [1]. In China, the estimated age-standardized incidence rate of lung cancer is as high as 34.8 per…

Degree Name by School School of Medicine [MED]; Doctor of Philosophy (PhD) Abstract PDAC is a highly malignant neoplasm that carries a very poor prognosis. PDAC development is a multistage transformation process that involves multiple genetic alterations that include activation of EGFR/HER2 and KRAS, and loss-of-function mutations in INK4A/ARF, p53…

Cardiac Comprehensive Kit analyzes 292 genes and covers major inherited cardiovascular disorders.   Genes Tested AARS2, ABCA1, ABCC6, ABCC9, ABCG5, ABCG8, ACAD9, ACADVL, ACTA1, ACTA2, ACTC1, ACTN2, ACVR1, ACVR2B, ACVRL1, ADAMTS2, AFF4, AGK, AKAP9, AKT3, ALDH18A1, ALMS1, ALPK3, ANK2, ANKRD1, APOA5, APOB, APOE, ATP6V0A2, ATP6V1A, ATP6V1E1, B3GALT6, B4GALT7, BAG3, BGN,…

Background: This prospective cohort study evaluated the feasibility of using endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) samples for comprehensive mutational analysis of cancer-related genes using microtissues. Methods: Fifty patients with suspected pancreatic cancer presenting consecutively at the Kindai University Hospital between January 2018 and January 2019 were enrolled. Cancerous tissues from…

[1] Urist MR, DeLange RJ, Finerman GA. Bone cell differentiation and growth factors[J]. Science, 1983, 220(4598): 680-686.[2] Wen XZ, Miyake S, Akiyama Y, et al. BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells [J]. Biochem Biophys Res Commun, 2004, 316(1): 100-106.[3] Heikinheimo KA, Laine MA,…

image: Genomic landscape of schistosomiasis-associated colorectal cancer. (A) Genetic characteristics of the SA-CRC. The number of mutations, the tumor mutation burden, the estimated MSI scores, and the predicted number of neo-epitopes of each sample were present. (B) Mutational landscape of recurrently mutated genes in SA-CRCs. Red arrow corresponds to the known…

In a study published in the journal Genes & Diseases, researchers from Naval Medical University and Soochow University conducted an in-depth investigation into the genomic landscape of schistosomiasis-associated colorectal cancer (SA-CRC). By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at…

Case Reports doi: 10.1002/pd.6414. Online ahead of print. Affiliations Expand Affiliations 1 Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, Hong Kong. 2 Department of Health, Clinical Genetic Service, Hong Kong, Hong Kong. 3 Prenatal Diagnostic Laboratory, Tsan Yuk Hospital, Hong Kong, Hong Kong. 4 Department of Paediatrics…

Phenotypes Associated with This Genotype Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Smad4tm1.1Rob mutation (0 available); any Smad4 mutation (36 available) Smad4tm2.1Rob mutation (0 available); any Smad4 mutation (36 available) Read more here: Source link

Abstract The signaling pathway of transforming growth factor-beta (TGFβ) plays crucial roles in the establishment of an immunosuppressive tumor microenvironment, making anti-TGFb; agents a significant area of interest in cancer immunotherapy. However, the clinical translation of current anti-TGFb; agents that target upstream cytokines and receptors remains challenging. Therefore, the development…

TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4…

Background: SMAD4 is a potent tumor suppressor. SMAD4 loss increases genomic instability and plays a critical role in the DNA damage response that leads to skin cancer development. We aimed to investigate SMAD4 methylation effects on mRNA and protein expression of SMAD4 in cancer and healthy tissues from patients with…

doi: 10.1096/fj.202300737R. Affiliations Expand Affiliations 1 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S1085, Rennes, France. 2 Univ Paris-Sud, Inserm, UMR_S0782, Clamart, France. 3 Faculty of Health Sciences, University of Macau, Macau SAR, China. Item in Clipboard Fabrice G Petit et al. FASEB J….

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui…

This study is a nationwide study including all 66 Danish patients who fulfilled the clinical criteria of JPS and/or had a PV in SMAD4 or BMPR1A. We found that almost 90% of patients with a clinical diagnosis of JPS had a PV in either BMPR1A or SMAD4. Endoscopy had been…

doi: 10.1016/j.exger.2023.112243. Online ahead of print. Affiliations Expand Affiliations 1 Key Laboratory of Neurological Function and Health & Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China. 2 Department of Pediatrics, University of California-Irvine, Irvine, CA 92697, USA. 3 Key Laboratory of Neurological…

Mice Senp2f/f mice were described as previously16. T cell-specific Senp2 knockout mice (CKO, Senp2f/fLckCre+/+) and control mice (WT, LckCre+/+) in C57BL/6 genetic background were raised and kept in the Academia Sinica SPF animal facility, according to the rule of the Animal Protection Act of Taiwan. Lck-Cre mice, Rag2−/− mice and CD45.1…

FIGURE 8. Reduction of neural markers in Smad4β morphant embryos is associated with reduction of mesodermal genes. A single blastomere injection of 20 ng of Smad4β-MO with the lineage tracer nuclear β-galactosidase at the two-cell stage resulted in suppression of the muscle…

[1] ZHAO Xueliang, WANG Shuyi, SUN Ke, SU Qian, WANG Wenlong, LIU Chunxia. Comparative Transcriptome Analysis of Albendazole-susceptible and Resistant Strains of Haemonchus contortus by RNA-Seq [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(9): 1940-1944. [2] YU Yan,…

smad4 (SMAD family member 4 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 31, lateral view, anterior left, dorsal up. This image is extracted from figure published in: Masuyama N et al. (1999), Image published in: Masuyama N et al. (1999) Copyright…

Overview Test order codeHelpLaboratory’s order or catalog code for the test (used in the order requisition form).: 22827 SMAD4 Sequence Analysis (Prenatal Sequence Analysis) This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis Loading data …… Click Indication tab for more information. Not provided…

Obstructive sleep apnea (OSA) patients are at special risk of suffering atherosclerosis, leading to major cardiovascular diseases. Notably, the transforming growth factor (TGF-β) plays a crucial role in the development and progression of atherosclerosis. In this context, the central regulator of TGF-β pathway, SMAD4 (small mother against decapentaplegic homolog 4),…

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then…

Organ fibrosis is the final common pathological pathway of many chronic diseases and is characterized by various injuries and insults with maladaptive tissue repair, followed by excessive collagen deposition into the extracellular matrix (ECM). Structural alterations lead to tissue stiffness, vascular rarefaction, hypoxia, proliferation, differentiation and activation of fibroblasts and…

MDPI and ACS Style Díaz-García, E.; García-Sánchez, A.; Sánz-Rubio, D.; Alfaro, E.; López-Fernández, C.; Casitas, R.; Mañas Baena, E.; Cano-Pumarega, I.; Cubero, P.; Marin-Oto, M.; López-Collazo, E.; Marin, J.M.; García-Río, F.; Cubillos-Zapata, C. SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea….

Objective To investigate the effect of 1, 25-(OH)2-VitD3 (VitD3) on renal tubuleinterstitial fibrosis in diabetic kidney disease. Methods NRK-52E renal tubular epithelial cells were divided into control group (5.5 mmol/L glucose medium treatment), high glucose group (25 mmol/L glucose medium treatment) and high glucose with added VitD3 group (25 mmol/L…

Multi-omics analyses of the ICC samples Following multiregional sampling of primary ICC cases, we performed multi-omics analyses, including genome, transcriptome, proteome, and metabolome analysis. We used 10 (67 samples), 11 (88 samples), 10 (49 samples) and 10 (49 samples) ICC cases for WES, whole-transcriptome sequencing, proteomic analysis, and metabolomic analysis,…

Introduction: Myhre syndrome (MS; OMIM #139210) is a rare connective tissue disorder presenting with cardiovascular, respiratory, gastrointestinal, and skeletal system findings. Fewer than 100 patients were reported until recently, and all molecularly confirmed cases had de novo heterozygous gain-of-function mutations in the SMAD4 gene. Dysregulation of the TGF-beta signaling pathway…

Image Caption Generation of the Smad4tm2.1Cxd allele. Schematic diagram of the floxed Smad4 allele pre (Smad4tm2.1Cxd) and post-Cre-mediated recombination. A 234-bp fragment could be amplified from the deleted Smad4 allele by PCR using primers 1 and 2 (P1/P2) after the Cre-mediated excision of exon 8 of Smad4, and a 2.5-kb…

. 2023 Apr;27(8):1045-1055. doi: 10.1111/jcmm.17216. Epub 2023 Mar 14. Affiliations Expand Affiliations 1 Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China. 2 Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. 3 Department of Plastic Surgery, The…

Phenotypes associated with this allele Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (35 available) Tg(Dppa3-cre/Esr1*)3Sait mutation (0 available) reproductive system • following tamoxifen treatment at E10.5-E11.5, some male germ cells abnormally enter meiosis at E14.5 Read more here: Source…

Grau AM, Zhang L, Wang W, et al. Induction of p21WAF1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells [J]. Cancer Res 1997; 57:3929. PubMed  CAS  Google Scholar  Wilentz RE, Su GH, Dai JL, et al. Immunohistochemical labeling…

1. Introduction Endometriosis is one of the most common gynecological diseases, affecting 5–10% of women of reproductive age [1]. It is characterized by the presence of endometrial-like tissue outside the uterine cavity, which is manifested by chronic pelvic pain and/or infertility in 35–50% of women [2,3,4]. The course of this…

Deciphering molecular targets to enhance sensitivity to chemotherapy is becoming a priority for effectively treating cancers. Loss of function mutations of SMAD4 in colon Cancer are associated with metastatic progression and resistance to 5-fluorouracil (5-FU), the most extensively used drug of almost all chemotherapy combinations used in the treatment of…

Background: Pancreatic adenocarcinoma is one of the cancers with the worst prognosis. The current treatment paradigm based on combination chemotherapy has improved survival over the last decade, but the disease is still fatal in most cases. New therapies exploiting the increasing understanding of the molecular pathology of the disease are…

Abstract Background: The pharyngeal arch arteries (PAAs) are precursor vessels which remodel into the aortic arch arteries (AAAs) during embryonic cardiovascular development. Cardiac neural crest cells (NCs) populate the PAAs and differentiate into vascular smooth muscle cells (vSMCs), which is critical for successful PAA-to-AAA remodeling. SMAD4, the central mediator of…

Identification of TGFβ signaling pathway mutations in endometrial cancer We profiled the data from uterine tumors deposited to the cBioPortal of Cancer Genomics for mutations of the TGFβ signaling pathway20,21 and identified several mutations in TGFβ-related receptors (TGFBR1, TGFBR2, ACVR1B, ACVR1C, ACVR2A, ACVR2B) and transcription factors (SMAD2, SMAD3, SMAD4) (Supplementary…

1 Introduction Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder that is a type of hamartomatous polyp syndrome, and its incidence rate is approximately 1/100000 (1). The main clinical feature is the presence of multiple juvenile polyps in the gastrointestinal tract, most often in the colorectal (98%) but…

Register for FREE to listen to this article Thank you. Listen to this article using the player above. ✖ Want to listen to this article for FREE? Complete the form below to unlock access to ALL audio articles. Scientists at VCU Massey Cancer Center uncovered a previously…

Overview Product name Description Rabbit polyclonal to Smad4 Host species Rabbit Tested applications Species reactivity Reacts with: HumanPredicted to work with: Mouse, Rat, Sheep, Horse, Cow, Dog, Pig, Chimpanzee,…

Overview Product name Description Rabbit monoclonal [SP306] to Smad4 – C-terminal Host species Rabbit Tested applications Species reactivity Reacts with: Mouse, Rat, Human Immunogen Synthetic…

(PDF) Chromosomal translocation disrupting the SMAD4 gene resulting in the combined phenotype of Juvenile polyposis syndrome and Hereditary Hemorrhagic Telangiectasia | Martin Larsen – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through…

Model for the functional interaction between Smad4 and Prdm16 during PDAC formation and progression. Credit: Journal of Cell Biology (2023). DOI: 10.1083/jcb.202203036 Scientists at VCU Massey Cancer Center have uncovered a previously unrecognized relationship between two sets of proteins that operate in tandem to fend off the growth of pancreatic…

Overview Product name Description Rabbit monoclonal [EP618Y] to Smad4 Host species Rabbit Tested applications Suitable for: WB, IHC-Pmore detailsUnsuitable for: Flow Cyt,ICC/IF or IP Species reactivity Reacts with: Mouse,…

Since this grant was first funded in 1985, it has been our goal to understand the molecular and cellular pathology of squamous cell cancers (SCC) of the aerodigestive tract, with the intent to develop novel molecular diagnostic, prognostic as well as therapeutic tools to improve the outcome of patients with…

. 2021 Apr;101(4):463-476. doi: 10.1038/s41374-020-00517-x. Epub 2023 Jan 4. Affiliations Expand Affiliations 1 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 2 Department of Pathology, Shanghai First People’s Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China….

Non-Coding RNA 2023, 9(1), 14; doi.org/10.3390/ncrna9010014 (registering DOI) Non-Coding RNA 2023, 9(1), 14; doi.org/10.3390/ncrna9010014 (registering DOI) Received: 8 December 2022 / Revised: 31 January 2023 / Accepted: 9 February 2023 / Published: 11 February 2023 Round 1 Reviewer 1 Report The authors present a novel mechanism by which MALAT1 promotes EMT in…

Clinicopathological characteristics The clinicopathological features of the 56 stage IV GC patients are shown in Table 1. There were 29 males and 27 females. The mean age was 65.8 years old. The tumor was located mostly in the middle third of the stomach. Approximately 69.6% of the 56 patients had…

Cat.No. : SMAD4-31193TH Optional Service: Optional requirements on this protein Product Overview : Recombinant full length human Smad4 with N-terminal proprietary tag; amino acids 1-552, 95kDa. Description : This gene encodes a member of the Smad family of…

SMAD4, MSX HU, 100UG | Merck Life Science Indonesia The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure…

Abstract Circular RNAs have been reported to be widely involved in cancer cell tumorigenesis and drug resistance; here, the aim of this study was to investigate whether circRNA Integrin Subunit Alpha 7 (ITGA7) (circ_ITGA7) was associated with the tumor growth and radiosensitivity of colorectal cancer (CRC). We found that circ_ITGA7…

Smad4tm2.1RobTargeted Allele Detail Symbol: Smad4tm2.1Rob Name: SMAD family member 4; targeted mutation 2.1, Elizabeth J Robertson MGI ID: MGI:3819836 Synonyms: Smad4deltaNES Gene: Smad4  Location: Chr18:73772080-73836851 bp, – strand  Genetic Position: Chr18, 49.51 cM Alliance: Smad4tm2.1Rob page Germline Transmission:  Earliest citation of germline transmission: J:141589 Parent Cell Line:  CCE/EK.CCE (ES Cell) Strain of…

TUESDAY, Nov. 22, 2022 (HealthDay News) — About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in JAMA Oncology. Andreana N. Holowatyj, Ph.D., from the Vanderbilt…

NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) AND Hereditary cancer-predisposing syndrome Based on: 1 submission [Details] Record status: current Accession: RCV001012497.1 Allele description [Variation Report for NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr)] NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) Gene: SMAD4:SMAD family member 4 [Gene – OMIM – HGNC] Variant type: single nucleotide variant Cytogenetic location: 18q21.2 Genomic location: Preferred name: NM_005359.6(SMAD4):c.1630C>A (p.Pro544Thr) HGVS:…

doi: 10.1002/kjm2.12574. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China. Item in Clipboard Yi Yu et al. Kaohsiung J Med Sci. 2022. Show…

Introduction Pancreatic cancer (PC) is one of the most aggressive and lethal cancers (1). Previous studies have shown that aging, environmental and behavioral changes are more closely related to the dramatic increase in the incidence of PC worldwide than genetic factors (2–5). A position paper published by the European Federation…

1Department of Pulmonary and Critical Care Medicine, Sinopharm Tongmei General Hospital, Datong, People’s Republic of China; 2China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Emergency, Chinese PLA General Hospital -Fourth Medical Center, Beijing, People’s Republic of China; 4School…

Introduction Oocyte competence and quality depend on communication between the oocyte and the cumulus and theca cells. In the preantral phase, the members of the transforming growth factor β (TGF-β) superfamily are responsible for this communication and play an important role in folliculogenesis. Members of the TGF-β superfamily are related…

Purpose: Hepatitis B virus (HBV) plays a crucial role in the progression of hepatocellular carcinoma (HCC). It is known that HBV-encoded X protein (HBx) can induce genetic alterations in some oncogenes and that SMAD4 is relevant for the development of some cancers, especially HBV-related HCC. Previously, it has been reported…

check quantity false For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006). Request More Information Buy Now Add…

Transcribed image text: 1. What gene did you choose? (SMAD4, BMP2, BMPR1A, BMPR1B, FBN1) FBN1 2. Describe the type of mutation (aberration) in your gene? Marfan syndrome 3. Is your assigned protein (DNA-mRNA-protein) a ligand, receptor, relay molecule, or structural protein? Structural protein Transduction 1. Signaling pathways may use mediators…

This website uses cookies to ensure the best experience. By continuing, you agree to our privacy policy. × Product successfully added to quote! × There are items in your quote. Brand: Reference GTX03325 Brand GeneTex Application IHC-P Storage Conditions Store as concentrated solution. Centrifuge briefly prior to opening vial. Store…

For a study, the researchers sought to see if genomic risk groups discovered by colorectal liver metastasis (CRLM) somatic mutation testing may be used for “molecularly-guided” adjuvant systemic chemotherapy and hepatic artery infusion of FUDR (SYS+HAI-FUDR). A prospective institutional database was analyzed for consecutive patients with resected CRLM and available…

import pandas as pd df = pd.DataFrame({‘case_id’:[‘1’, ‘1’, ‘1’,’2′,’2′,’2′], ‘Gene’:[‘KRAS’,’SMAD4′,’TP53′,’TP000′,’SMAD000′,’TP000′], ‘ch_a’:[0,1,0,0,0,0], ‘ch_b’:[0,0,0,1,1,0], ‘ch_c’:[0,0,0,1,1,0]}) case_id Gene ch_a ch_b ch_c 0 1 KRAS 0 0 0 1 1 SMAD4 1 0 0 2 1 TP53 0 0 0 3 2 TP000 0 1 1 4 2 SMAD000 0 1 1 5 2…

Introduction Hepatic fibrosis (HF) is a pathological phenomenon produced in the process of long-term damage and repair in the liver [1,2]. During the formation of HF, hepatocytes are damaged by various factors, such as chronic liver disease, and excessive intake of alcohol, and secrete a variety of cytokines [3]. Subsequently,…

This article was originally published here Case Rep Pathol. 2022 Feb 8;2022:2640456. doi: 10.1155/2022/2640456. eCollection 2022. ABSTRACT Colorectal carcinoma with noncohesive tumor cells has been described in tumors with signet ring cells (mucinous adenocarcinoma and signet ring cell adenocarcinoma) and rhabdoid feature (carcinoma with sarcomatoid component). Cases of carcinoma with…

image: Stained liver tissue shows the complementary occurrence of pVHL and SMAD proteins: Where pVHL (green) is abundant, SMAD2/3 (red) is scarce, and vice versa. Cell nuclei are stained blue. The lower right picture shows all three colours combined. Photos: Xinglai Cheng/Goethe University view more  Credit: Xinglai Cheng/Goethe University FRANKFURT/HEIDELBERG. Signal…

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

The micro ribonucleic acid (microRNA) [MiR-181a] is downregulated in the kidneys of rodents and patients suffering from high blood pressure (BP). The miR-181a is a posttranslational inhibitor of renin articulation in vitro, yet pleiotropic systems by which miR-181a may impact BP are unclear. Whether cancellation of miR-181a/b-1 in vivo changes…

Introduction Pancreatic ductal adenocarcinoma (PDAC) is a lethal gastrointestinal disease with increasing morbidity, which also has a growing impact on cancer-specific mortality worldwide.1 Nearly 40% of all PDAC cases are localized to the pancreas and characterized with the involvement of major vascular structures, leading to unresectable disease without metastases detected…

Possible biomarkers for prognosis and clinical outcomes were identified, through the use whole exome sequencing and RNA sequencing, as therapeutic targets for patients with pancreatic ductal adenocarcinoma (PDAC), according to a recent study. The study, published in Therapeutic Advances in Medical Oncology, also reconfirmed genomic landscapes, major driver mutations, and…