Tag: STAR

2023 gene therapy research STAR Grant winners announced

At PacBio, enabling the promise of genomics to better human health cuts right to the core of everything we do.That’s why in 2023 we created the STAR (Student Travel Awarded Researcher) Grant program. This exciting funding opportunity is intended to assist up-and-coming researchers in genomics-aligned fields with sequencing services and…

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Twisted DNA Increases CRISPR Off-target Effects

At the end of 2023, the FDA approved Casgevy for sickle cell disease, its first approval for a therapeutic that used the genome editing tool clustered regulatory interspaced palindromic repeats (CRISPR) to specifically inactivate a human gene as a treatment for a genetic disease. While CRISPR-based gene therapies could potentially…

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Samsung Galaxy S24 series launch: A comparison with Google’s Pixel 8 event |

Samsung recently launched the Galaxy S24 series of smartphones and teased the Galaxy Ring at its annual Unpacked 2024 event. However, unlike yesteryears, Samsung focussed a lot on AI – Collins Dictionary’s word of the year for 2023. The South Korean company was pretty aggressive with the new AI features…

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Google Vertex AI | Haystack

Use Google Vertex AI Models with Haystack Authors deepset Table of Contents Overview Vertex AI is a machine learning (ML) platform that lets you train and deploy ML models and AI applications, and customize large language models (LLMs) for use in your AI-powered applications. This integration enables the usage of…

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Top 20 Hadoop Competitors and Alternatives

Hadoop is an open-source big data analytics platform headquartered in Baltimore, Maryland. The solution evolved from the Google File System paper published by Doug Cutting and Mike Cafarella in October 2003 as part of the Apache Nutch project. The co-founders moved the platform to the Hadoop subproject in 2006. In…

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How I Won Singapore’s GPT-4 Prompt Engineering Competition | by Sheila Teo | Dec, 2023

A deep dive into the strategies I learned for harnessing the power of Large Language Models Celebrating a milestone — The real win was the priceless learning experience! Last month, I had the incredible honor of winning Singapore’s first ever GPT-4 Prompt Engineering competition, which brought together over 400 prompt-ly…

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Decent Uniquely mapped reads but no features

Decent Uniquely mapped reads but no features 0 Hi guys, I am analysing a mRNASeq dataset of extracellular vesicles. I get decent results for mapping using STAR Number of input reads | 32143093 Average input read length | 100 UNIQUE READS: Uniquely mapped reads number | 22862852 Uniquely mapped reads…

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The best biotech movies to watch this winter

It’s the holiday season, and what’s better to do than cuddle up in bed and watch a movie? We want to make sure you’re not missing out on some binge-worthy biotech movies this December. So, we have created a watchlist just for you. Here are some biotech movie recommendations to…

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2023-12-20 | NDAQ:DRMAW | Press Release

– About 550 patients will be treated once weekly for 12 weeks – – STAR-1 topline results expected in first quarter of 2025 – – Acne affects about 50 million patients in the U.S. – SAN DIEGO, CA / ACCESSWIRE / December 20, 2023 / Dermata Therapeutics, Inc. (Nasdaq:DRMA, DRMAW)…

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Trying to understand STAR fastqLog.final.out File

Trying to understand STAR fastqLog.final.out File 0 Hello, I am analyzing ribo-seq data and am trying to understand if my interpretation of star’s log file is correct. I do not have extensive bioinformatics/computational experience, so it’s been a bit difficult trying to understand how to proceed (the guides online are…

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Complete Tutorial Guide / AvaxHome

Parallel Computing With R & Rstudio: Complete Tutorial GuidePublished 12/2023MP4 | Video: h264, 1920×1080 | Audio: AAC, 44.1 KHzLanguage: English | Size: 1.30 GB | Duration: 1h 30m R Programming, RStudio, Parallel Computing, Multicore, Data Science, Speed Optimization What you’ll learn Understand core parallel computing concepts. Explore essential R packages…

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Abbott’s Trim the Christmas Tree, Summer Gives Phyllis Advice

Weds Dec 20: Today on Young and Restless, Tucker tries to get Devon to invite him for Christmas, Ashley admits she feels sorry for Tucker, Summer yells at Tucker to stay away from her mother, and the Christmas tree trimming commences.  Tuesday’s recap: Disguised Jordan Sneaks Into Claire’s Room, Victor…

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Wolverine’s HTTP Gets a Lot Better at OpenAPI (Swagger) – The Shade Tree Developer

Hey, did you know that JasperFx Software is ready for formal support plans for Marten and Wolverine? Not only are we trying to make the “Critter Stack” tools be viable long term options for your shop, we’re also interested in hearing your opinions about the tools and how they should change. We’re also certainly open to help you succeed with…

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3 futuristic ways ultrasound is revolutionising healthcare

Nobody likes the process of getting vaccinated, particularly young children, some of whom are terrified of needles. But research presented in Sydney earlier this month opens the door to a painless alternative – one whose primary downside might be that it’s actually a bit boring. And that’s just one way…

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LncRNA pipeline

Forum:LncRNA pipeline 0 HI ALL, I AM WORKING ON FINDING LNCRNA, I WOULD LIKE TO CHECK IF MY PIPELINE IS RIGHT FIRST I MAP USING STAR AND THEN SORT IT AND THEN GO FOR HTSEQ -GET THE COUNT DATA AND DO DESEQ. FOR LNCRNA EXTRACTION FROM RNA SEQ, I AM…

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Secret vulnerabilities of cancer’s ‘Death Star’ revealed

The study presents the first complete control map for any protein and was published on 18 December in the journal, Nature. KRAS is one of the most frequently mutated genes in cancers of many types. It is found in one in 10 human cancers, with higher prevalence in deadly types…

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Sacramento bee obituaries for today

Sacramento,CA Obituaries. The Dignity Memorial® online obituary search tool gives you access to obituaries from thousands of locations across North America. You can search by first or last name, state and publication date. Once you find the obituary you are looking for, you can get important information about upcoming services,…

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Blackstone aims to trim PGP Glass stake; KKR eyes 50% stake in Cotiviti

S&P Global Market Intelligence presents In Play Today, a periodic summary of potential private equity deal activity, including rumored transactions. This summary is based on information obtained on a best-efforts basis and may not be inclusive of all potential deal activity. – TPG Inc., Peak XV Partners and Matrix Partners…

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Cancers Death Star Secret Weaknesses Unveiled

Researchers at the Centre for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret vulnerabilities which can be exploited to control the effects…

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Experts expose secret weaknesses in ‘undruggable’ cancer’s ‘death star

The KRAS gene is categorized among oncogenes, a class of genes with the capacity to transform healthy cells into cancerous ones when they undergo mutations, according to Medline Plus.  This gene is one of the most frequently mutated genes in cancers of many types. Scientists stated that its presence in…

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Helen Flanagan shows off her figure in a white mini skirt and black fur-trim top as she poses for sizzling snaps (and her engagement ring is STILL on)

Helen Flanagan looked stunning as she posed for a slew of racy Instagram pictures on Sunday. The former Coronation Street star, 33, displayed her toned physique in sizzling mirror selfies, which also clearly showed her engagement ring from ex-fiancé Scott Sinclair. Helen and the Bristol Rovers footballer split in July 2022 after 13…

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Google unveils MedLM, the healthcare AI

Tech & Startup Desk Mon Dec 18, 2023 03:43 PM Last update on: Mon Dec 18, 2023 03:51 PM MedLM is built upon the foundation of Med-PaLM 2, Google’s large language model (LLM) for the medical domain. Image: Google “> MedLM is built upon the foundation of Med-PaLM 2, Google’s…

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‘Grateful’ Cristiano Ronaldo Reacts After Google Announces Portuguese Football Star As Most Searched Athlete in Search Engine’s History (See Post)

In a video posted a few days ago by Google, Cristiano Ronaldo is the most searched athlete, and consequently footballer, in the 25-year history of Google. Google celebrated its Silver Jubilee by posting a video showing the highest searches for select queries, and Cristiano Ronaldo tops the list of the athletes. The…

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Google Vertex AI API | Freelancer

Its a simple task. You will need to setup the starter code to deploy Google Vertex AI api on my computer (especially Google Gemini AI API). I am facing issues with authenticating on Google api correctly. You will need to guide me to thru the steps to setup a new…

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X-Line trim in a detailed walkaround video

Kia India has finally revealed the Sonet facelift in India. The bookings for this all-new updated model will commence from the 20th of December, and the price reveal will be done next year. Currently, the company has shown the vehicle in the flesh, and walkaround videos of this sub-compact SUV…

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The First Launch Of “the Human Memories Project” Initiated By GIGATREE Of Singapore Was Successful

PRESS RELEASE Published December 15, 2023 The first launch of “The Human Memories Project” initiated by GIGATREE of Singapore was successful. The launch, which carried two satellites (Elliptical Space-Time Star Pool 1, Group II, Stars A/B), was launched at 12:10 p.m. on December 4, 2023, by the Long March 2C Y75…

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Editorial Roundup: Crop insurance has room for budget trim – Albert Lea Tribune

Editorial Roundup: Crop insurance has room for budget trim Published 8:50 pm Friday, December 15, 2023 The U.S. Government Accountability Office and conservative think tanks agree on one point when it comes to farm programs: They should be cut. While subsidies have long been accepted as a way to keep…

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How to land a scientific position even in a struggling economy

Scientists say they’re finding it increasingly difficult to find a new roles, but there are ways to boost the chances of job applications.Credit: Patrick T. Fallon/Bloomberg via Getty Challenging economic circumstances are affecting scientists’ job searches, with greater competition for limited posts. Nature’s first global survey of postdoctoral researchers revealed…

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Explore new gastronomic, arts, cultural and entertainment horizons at GEG’s exciting Phase 3 Projects, Business News

The Future. Diversified. Celebrating Macau’s New Cultural & Entertainment Landmark MACAU, Dec. 15, 2023 /PRNewswire/ — Galaxy Entertainment Group (“GEG”) unveils its Phase 3 projects with a grand opening ceremony on December 13. The spectacular new phase including Galaxy International Convention Center (GICC), Galaxy Arena, Andaz Macau and Raffles at Galaxy Macau….

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4 Steps that will help you make the best movie of all times | by Shay Shalem | Dec, 2023

As a filmmaker who wants to have a blockbuster Hollywood movie, you think to yourself, what is the secret? Besides the fact that you need a good story, what else is important? Here, I’ve collected the secret ingredients that nobody tells you but really matter to succeed. And to break…

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Sault Innovation Centre may need to trim budget, grow revenue quicker

Breadcrumb Trail Links Politics News Local News City council cut $277,890 from the levy — effectively giving notice to the SSMIC that they’re annual funding may not exist after 2024. Author of the article: Elaine Della-Mattia Published Dec 14, 2023  •  Last updated 2 hours ago  •  4 minute read The…

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Kim Kardashian shows off her VERY trim waist as she joins Kendall Jenner, Ivanka Trump at Justin Timberlake concert in Vegas Grand Opening

Kim Kardashian showcased her jaw-dropping physique in a figure-hugging black dress while attending Justin Timberlake‘s invite-only show at the Fontainebleau in Las Vegas. While enjoying a girls’ night out with her sister Kendall Jenner and longtime pal, Ivanka Trump, on Wednesday, the reality star, 43, commanded attention in her sexy knitted frock,…

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MAPS Celebrates Submission of New Drug Application to FDA for MDMA-Assisted Therapy for PTSD – Multidisciplinary Association for Psychedelic Studies

FOR IMMEDIATE RELEASE: December 13, 2023 MAPS incubated the program that generated the first NDA submission for any psychedelic-assisted therapy Submission represents 30-plus years of philanthropy-driven clinical research into potential use of MDMA-assisted therapy for PTSD If accepted for review by the FDA, the application could be approved next year  …

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Galaxy Entertainment Group Unveils Phase 3 Grand Opening. The Future. Diversified. Celebrating Macau’s New Cultural & Entertainment Landmark.

[The content of this article has been produced by our advertising partner.] Galaxy Entertainment Group (“GEG”) unveils its Phase 3 projects with a grand opening ceremony today! The spectacular new phase including Galaxy International Convention Center (GICC), Galaxy Arena, Andaz Macau and Raffles at Galaxy Macau. Embodying the service philosophy…

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Could Intellia Therapeutics Become the Next CRISPR Therapeutics?

Intellia Therapeutics (NASDAQ: NTLA) and CRISPR Therapeutics (NASDAQ: CRSP) have one big thing in common: They both specialize in the hot area of gene editing, or the repairing of faulty genes responsible for disease. But CRISPR Therapeutics is farther along on the path to commercialization, recently scoring its first product…

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Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputation

Abstract Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for antidepressant metabolism and polymorphisms of these genes have been determined to predict metabolite levels. Nonetheless, more evidence is needed to understand the impact of genetic variations on antidepressant response. In this study, individual clinical and genetic data from 13…

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Using STAR’s readspergene.tab.out outputs to make gene-level count matrix for DESeq2 using tximport

Using STAR’s readspergene.tab.out outputs to make gene-level count matrix for DESeq2 using tximport 1 @e0db819c Last seen 1 day ago United States Hi, I am new to RNA-seq analysis. I have finished RNA alignment using STAR, and got ReadsPerGene.out.tab outputs. I am trying to use tximport to build a gene-level…

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2024 Toyota Corolla Cross: Pricing and details for Canada | Car News

•    2024 Toyota Corolla Cross: Here is pricing for the new year. Toyota brings virtually no changes to its Corolla Cross small SUV for 2024, the only modification worth mentioning being upgraded new 18-inch wheels for the LE Premium trim. Other than that, the offering remains the same, save for…

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Meet Single’s Inferno season 3 cast

The Single’s Inferno season 3 cast are officially here, hoping to find love on the Netflix series. Following the success of seasons 1 and 2, the hottest and most flirty singles search for love on a deserted island. The only way to escape? To match for a romantic night in…

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Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia

Rasche M, Zimmermann M, Borschel L, Bourquin J, Dworzak M, Klingebiel T, et al. Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012. Leukemia. 2018;32:2167–77. Article  PubMed  PubMed Central  Google Scholar  Manola KN. Cytogenetics of pediatric acute…

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Running STAR aligner on paired-end reads as single-end read

Running STAR aligner on paired-end reads as single-end read 1 Hi, I am just curious. Can we use STAR aligner to align the paired-end reads as a single-end? What are the consequences of the output of such alignment? RNA-Seq paired end single end STAR align • 17k views Yes, STAR…

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2022 Hyundai Ioniq 5: Every Trim Compared

The Hyundai Ioniq 5 is the South Korean brand’s premier electric crossover, which launched the all-electric Ioniq portfolio in the U.S. The mid-size SUV in electric cars neatly balances futuristic aesthetics with contemporary design cues. It creates a unique-looking product that stays close to conventional car designs. TOPSPEED VIDEO OF…

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How Does Tesla’s Ludicrous Mode Compare to Plaid?

The word “ludicrous” means so foolish, unreasonable, or out of place as to be amusing or ridiculous. Considering this definition, does it make sense that Elon Musk used this term to describe the high-performance mode of Tesla’s electric vehicles? Absolutely. The eccentric CEO gave us Ludicrous Mode and Ludicrous+ Mode…

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Agencies Trim the Trimmings at Bay Area Holiday Parties

It’s holiday party time for commercial and residential brokerage firms. While many agencies report that they are trimming back on the trimmings this year, all say post-COVID morale building is still at the heart of their downscaled events.  Pre-pandemic, Compass held its San Francisco party at The Brixton for years,…

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Ada Nicodemou shows off her trim pins in glistening frock as she leads the arrivals at Channel Seven Christmas bash alongside Sam Mac

By Marta Jary For Daily Mail Australia Published: 06:56 GMT, 9 December 2023 | Updated: 11:01 GMT, 9 December 2023 Ada Nicodemou was ready for a festive good time on Saturday night.  The Home and Away star was among the celebrities heading in to the Channel Seven Christmas bash in Sydney. …

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Cindy Crawford’s ’90s Bandage Mini and Fur-Trim Gloves

There are perfectly good celebrity style moments, and then there are the looks that really stick with you, the ones you try desperately to recreate at home. In ‘Great Outfits in Fashion History,’ Fashionista editors are revisiting their all-time favorite lewks. The ‘90s would not have been the same without…

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Ambiguous genes due to aligners and their impact on RNA-seq data analysis

Datasets To avoid the so-called ‘dataset bias’20,that some datasets are generated with specific structures and thus the results are ‘over-optimistic’ (in the case of working with our novel method), we performed the analysis in the light of several real datasets (see Table 4). We used four different datasets from the NCBI…

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Postdoctoral Fellowship in Bioinformatics at Aalborg University

Duration: Fixed-term (3 years; full-time)   The National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), based at Aalborg University (AAU) in Copenhagen, is looking to recruit a talented researcher for a 3-year postdoc in bioinformatics from 1st May 2024, at the latest. We are searching for the…

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How to properly mock a (Pysam) read

I am creating a custom softclipping tool due to a limitation found in Ampliconclip Issue softclipping reads when they belong and don’t belong to a common amplicon. I am progressing ok in my development and I am developing tests. I found some limitations when I try to mock a Pysam…

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Opinion on miRNA pipeline

Opinion on miRNA pipeline 0 Dear colleagues, I am currently in the process of evaluating miRNA Seq data and would like to present my pipeline for your review. Given the absence of a dedicated bioinformatician in my department, particularly for this specific use case, I am eager to gather feedback…

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Charmm36-jul2022.ff – User discussions – GROMACS forums

GROMACS version:GROMACS modification: Yes/NoHere post your question I am trying to generate amylin 2L86.top using CHARMM36-jul2022.ff and TIP3P. Amylin has 37 residues but the last NH2 is considered as residue 38. Although AMBERsb-star-ILDN.ff works with 38 resiues”, Charmm36-jul2022 does not work (see below):Fatal error:Residue type ‘NH2’ not found in residue…

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Google launches Gemini, new AI model to compete with GPT-4

Thu Dec 7, 2023 12:52 PM Last update on: Thu Dec 7, 2023 05:11 PM Gemini, Google’s latest suite of AI models, has already been integrated to Google Bard, and will be implemented in Google Search and ad products soon. Image: Google “> Gemini, Google’s latest suite of AI models,…

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Advanced Emerging Techniques for Forensic DNA Analysis: STRs, SNPs, and mtDNA Analysis

Alshehhi A, Almarzooqi A, Alhammadi K, Werghi N, Tay GK, Alsafar H (2023) Advancement in human face prediction using DNA. Genes (Basel) 14:136. doi.org/10.3390/genes14010136 CrossRef  CAS  PubMed  Google Scholar  Amorim A, Fernandes T, Taveira N (2019) Mitochondrial DNA in human identification: a review. PeerJ 7:e7314. doi.org/10.7717/peerj.7314 CrossRef  PubMed Central  PubMed …

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Jessica Simpson shows off her trim waist in skintight top and sequin trousers in new snap for her clothing label

By Sarah Sotoodeh For Dailymail.com Published: 19:51 GMT, 6 December 2023 | Updated: 20:09 GMT, 6 December 2023 Jessica Simpson showcased her trim waist in a new snap on her Instagram page for her brand Jessica Simpson Style. The mother of three, 43, wore a white bodysuit paired with sequin…

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Google Releases Gemini Generative AI Model Designed to Match and Exceed OpenAI’s GPT-4 and ChatGPT

on December 6, 2023 at 12:30 pm Google has officially unveiled its new Gemini generative AI model after nearly a year of anticipation. Gemini comes in three sizes and is officially multimodal out of the gate, though with limited availability for many of the features showcased by Google in an…

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A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes

Hoareau, L. & DaSilva, E. J. Medicinal plants: A re-emerging health aid. Electron. J. Biotechnol. 2, 3–4 (1999). Google Scholar  Jahan, I. & Ahmet, O. Potentials of plant-based substance to inhabit and probable cure for the COVID-19. Turk. J. Biol. 44, 228 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar …

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Strong chemotaxis by marine bacteria towards polysaccharides is enhanced by the abundant organosulfur compound DMSP

ISCA fabrication VeroGray polymer was used to create 3D-printed moulds on an Objet30 3D printer (Stratasys), using previously described protocols32. Each ISCA consisted of 25 wells arranged in a 5 × 5 array. Each 110 µL well possessed a 800-μm-diameter port that connected the inside of the well with the surrounding seawater and…

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Available AWD, Trim Levels, Premium Care Plan, Starting MSRP & More

The 2024 Infiniti QX60 will enter the new model year essentially unchanged. Infiniti launched the all-new, second-gen QX60 in 2022 to lock horns with the best of the best in the midsize luxury crossover segment, a virtual battlefield dominated by renowned nameplates like the Mercedes-Benz GLE, BMW X5, Porsche Cayenne,…

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Tech for cattle disease diagnostics edges into the Star Trek age

Remember the COVID rapid test? That was a point-of-need test designed to find a target and match it to a “binder” which then changes the colour if it’s positive or negative. The same principle is applied to the rapid lateral flow device test for anthrax, Dr. Anatoliy Trokhymchuk explains, which…

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Genetic risk converges on regulatory networks mediating early type 2 diabetes

Kahn, S. E., Hull, R. L. & Utzschneider, K. M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840–846 (2006). Article  ADS  PubMed  Google Scholar  Halban, P. A. et al. β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care…

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Solved Import the dataset into your RStudio. We want to test

Transcribed image text: Import the dataset into your RStudio. We want to test if there is a correlation between a star’s magnitude ( x-axis) and its temperature ( y-axis). Test if the data in each column are normal or not normal using a shapiro.test. Which column(s) have normally distributed data?…

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Bam files generated with STAR cause a segmentation fault core dump error when used with another tool

I am mapping RNA-Seq data using STAR, using multi-sample two-pass mapping. I first mapped all samples with one-pass then concatenated their SJOut files and filtered junctions. I launched the second mapping by using this SJOut file. I used this command to generate genome : ` /home/STAR-2.7.10b/bin/Linux_x86_64/STAR \ –runThreadN 10 \…

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Senior Bioinformatics Scientist Job in Minnesota

We are seeking a highly motivated bioinformatician to join the Institute on the Biology of Aging and Metabolism (iBAM) and the Department of Genetics, Cell Biology, and Development at the University of Minnesota. Aging is a natural process throughout an entire life course. Focusing on health and well-being, in…

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Without RCT FDA May Consider Estrogen Approval For Gender Incongruence

Kenny Caldwell takes testosterone as part of their gender-affirming healthcare. But their pharmacist … [+] refused to give them the prescription they normally pick up every month, citing the state’s restrictions on dispensing controlled substances. (Rich Sugg/The Kansas City Star/Tribune News Service via Getty Images) TNS The Food and Drug…

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Genomic analysis of Coccomyxa viridis, a common low-abundance alga associated with lichen symbioses

Honegger, R. The lichen symbiosis: What is so spectacular about it?. Lichenologist 30, 193–212 (1998). Article  Google Scholar  Grube, M. & Berg, G. Microbial consortia of bacteria and fungi with focus on the lichen symbiosis. Fung. Biol. Rev. 23, 72–85 (2009). Article  Google Scholar  Spribille, T. et al. Basidiomycete yeasts…

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Young talent Mumba soars from community to Red Arrows Premier

Zambia: Ackim Mumba is another young, talented player in the books of Red Arrows, rising through community and academy football to the top flight of the Zambian game. Born on a sunny day of October 4th, 1996, Ackim started his school at Kabanana Primary School before moving to El Elion…

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Here’s what AWS revealed about its generative AI strategy at re:Invent 2023

At AWS’ annual re:Invent conference this week, CEO Adam Selipsky and other top executives announced new services and updates to attract burgeoning enterprise interest in generative AI systems and take on rivals including Microsoft, Oracle, Google, and IBM.  AWS, the largest cloud service provider in terms of market share, is…

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Kelly Clarkson, 41, wows in white as she emphasizes trim physique ahead of exciting evening

Another day, another showstopping appearance by Kelly Clarkson. The singer and talk show host dazzled in a belted ensemble as she was photographed at the pre-taping of her performance at the tree lighting ceremony at Rockefeller Plaza. Kelly looked festive in a long, white fur coat which was cinched at the…

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FDA Extends Review Time for Italfarmaco’s Duchenne Agent Givinostat

Weeks before a decision was expected to be made for Italfarmaco’s investigational agent givinostat, the FDA informed the company it has extended the review process, with a new scheduled PDUFA of March 21, 2024. Givinostat, a proprietary histone deacetylase (HDAC) inhibitor, is currently in development as a treatment for Duchenne…

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WO2017055487A2 – A METHOD FOR DIAGNOSING A DISEASE BY DETECTION OF circRNA IN BODILY FLUIDS

“Current Protocols in Molecular Biology“, 1991, JOHN WILEY & SONS, pages: 6.3.1 – 6.3.6 “Quantitative monitoring of gene expression patterns with a complementary DNA microarray.“, SCIENCE, vol. 270, no. 5235, 1995, pages 467 – 70 ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 – 410 ALTSCHUL ET…

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Examining New Agents for MDD Treatment (AXS-05)

Transcript Gus Alva, MD, DFAPA: With that in mind, what I’d like [us] to think about is maybe taking into consideration 3 relatively newer agents that we have at our disposal right now. Because what I’d like to do is maybe have you [all] ponder the point of time-to-treatment response…

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Bioinformatics Institute, A*STAR hiring Computational Scientist in Singapore

Computational Scientist, Research Data Integration Group, Biomedical Datahub Division, Bioinformatics Institute (A*STAR)   About us Data science is an important component of biomedical and translational research, where data of multiple modalities are being constantly generated at unprecedented scale. The Research Data Integration group in the Biomedical Datahub Division of the…

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Star Wars’ The Eye of Darkness Searches for Hope in the Darkest of Times (Review)

Warning: The following about Star Wars‘ The Eye of Darkness searching for hope in the darkest of times contains mild spoilers. Starlight Beacon has been destroyed. Marchion Ro and the Nihil have dealt a near-fatal blow to the Republic and the Jedi. George Mann’s The Eye of Darkness kicks off…

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Viral genes not showing up in combined mouse+virus alignment

Viral genes not showing up in combined mouse+virus alignment 1 I created a combined MHV-A59 and mm10 fasta and GTF file using the linux cat command. The last two entries of the mm10 and first two of the A59 of the combined GTF looks like this: I then made a…

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Discrepancy in total number of bases in trimmed read1 and read2 files after BBDuk

Discrepancy in total number of bases in trimmed read1 and read2 files after BBDuk 0 Hi all, After performing adapter trimming with bbduk.sh, I found that the total number of bases in the read1 file is different compared with the read2 file from FastQC quality check. Below was the code…

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Walmart, Aldi, Sprouts, others received fruit linked to deadly Listeria outbreak

More details have become available abut recalled peaches, plums and nectarines linked to a deadly outbreak of infections from Listeria monocytogenes. Eleven people from coast to coast have been sickened with one reported dead and the other 10 hospitalized. Whole genome sequencing linked the patients together using DNA fingerprints of…

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Running STAR on fastq file generated from a RNA-seq experiment

Running STAR on fastq file generated from a RNA-seq experiment 1 Hi, I am new to bioinformatics, especially on the command line. I am trying to run STAR alignment on pairs of fastq.gz files from several samples generated as part of an RNAseq experiment. My goal is to perform splice…

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Tricorder Tech: Sequencing DNA in Space

NASA is not often known for making the best use of existing COTS (commercial off the shelf technology) aboard the ISS. Then again, sometimes they are. This is an example of when the agency really grabs cutting edge biotech and sends it into space. There’s usually quite a lag time….

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DEseq2 input

DEseq2 input 1 Hello Guys, @Michael Love I have a transcriptomics dataset and did rnaseq/nf-core pipeline by salmon-star. my output of the salmon-star folder is as follows: salmon.merged.gene_counts.tsv salmon.merged.gene_counts_length_scaled.tsv salmon.merged.gene_counts_scaled.tsv salmon.merged.gene_lengths.tsv salmon.merged.gene_tpm.tsv salmon.merged.transcript_counts.tsv salmon.merged.transcript_lengths.tsv salmon.merged.transcript_tpm.tsv tx2gene.tsv my question is: which one of these files should be an input for Deseq2…

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SMART Unveils Faster, Safer T-Cell Therapy with New Detection Method

Singapore, 27 November 2023 – Researchers from Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Singapore Centre for Environmental Life Sciences Engineering (SCELSE) and Massachusetts Institute of Technology (MIT), have developed a…

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Should SMART-seq2 data be deduplicated in STAR?

Should SMART-seq2 data be deduplicated in STAR? 0 Hi Everyone, I am running STAR-solo on SMART-seq2 data. In one manual (github.com/alexdobin/STAR/blob/master/docs/STARsolo.md), the Exact mode was recommended plate-based sequencing, which is about deduplication. However, I am still confused whether to deduplicate the reads or not, since many discussion said deduplication is…

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Indexing by bowtie2 but aligning with STAR

Indexing by bowtie2 but aligning with STAR 1 Ciao, I’m a Bioinformatics newbie encountering an issue with STAR alignment. I downloaded the mm10 genome and indexed it with Bowtie 2. When attempting to run mapping with STAR, I received the following error message. “FATAL ERROR: could not open genome file…

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Extracting list of identical items from several excel files

Extracting list of identical items from several excel files 0 Hi guys, I have 10 excel files with several columns and rows. The column headers are similar in all file but for the rows some items are similar while others are not. Below is an excerpt for one of the…

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Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production

Ward, Z. J. et al. Projected U.S. state-level prevalence of adult obesity and severe obesity. N. Engl. J. Med. 381, 2440–2450 (2019). Article  PubMed  Google Scholar  Khaodhiar, L., McCowen, K. C. & Blackburn, G. L. Obesity and its comorbid conditions. Clin. Cornerstone 2, 17–31 (1999). Article  CAS  PubMed  Google Scholar …

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It was a dream working with the cast of Ghum Hai Kisikey Pyaar Meiin: Riddhi Rawal

Young actress Riddhi Rawal who was seen in Ghum Hai Kisikey Pyaar Meiin talks about her aspirations as an actor. Read it here to know what she has to say. Read it here. Young actress Riddhi Rawal who was seen in the role of Rewati Gokhale in Star Plus’ Ghum…

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Early career job hopping | The Daily Star

Fri Nov 24, 2023 10:33 PM Last update on: Fri Nov 24, 2023 10:41 PM Illustration: Junaid Iqbal Ishmam “> Illustration: Junaid Iqbal Ishmam “The first couple of jobs after graduation are always for developing skills and gaining experience” is something I have heard too many times, and from people…

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NOT REAL NEWS: A look at what didn’t happen this week

A roundup of some of the most popular but completely untrue stories and visuals of the week. None of these are legit, even though they were shared widely on social media. The Associated Press checked them out. Here are the facts: ___ No evidence that DNA sequence used in Pfizer…

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A look at what didn’t happen this week

FILE – A health worker administers a dose of COVID-19 vaccine during a vaccination clinic in Reading, Pa. On Friday, Nov. 24, 2023, The Associated Press reported on stories circulating online incorrectly claiming Pfizer’s COVID-19 vaccine contains a DNA sequence called Simian Virus 40 that can cause health problems, including…

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Post-Doctoral Associate – Bioinformatics & Computational Biology Job in Minnesota

Required Qualifications: • A PhD degree in related field (Bioinformatics, Computer Science, Statistics, etc.) obtained in the last 1~2 years.• Strong quantitative data analysis background (machine learning, biostatistics, etc.) and/or computational genomics/genetics experiences (spatial transcriptomics, single-cell sequencing, high-throughput omics sequencing data analysis, TWAS/GWAS, etc.) or other relevant areas.• Strong…

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Multi-mapped reads in Ribo-Seq data, discard or keep?

Multi-mapped reads in Ribo-Seq data, discard or keep? 0 Hi all, I am for the first time doing a TE analysis using Ribo-seq and RNA-seq data, however I have a few question regarding the analysis. I have used STAR to align the reads from both datasets to the Human genome….

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Diferences between TCGAbiolinks and cBioportal

Hi, Im exploring and integrating the LUAD TGCA transcriptomic and genomic data. Im trying to do so both with TCGAbiolinks in R and cBioportal. With TCGAbiolinks I acces the data this way (bioconductor.org/packages/devel/bioc/vignettes/TCGAbiolinks/inst/doc/analysis.html#TCGAvisualize:_Visualize_results_from_analysis_functions_with_TCGA%E2%80%99s_data) query <- GDCquery(#legacy = T, project = “TCGA-LUAD”, data.category = “Transcriptome Profiling”, data.type = “Gene Expression Quantification”,…

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Salmon (or other pseudo-mappers) for multi-species RNAseq read filtering

Hello all, Background: I’ve inherited a new RNAseq data set and am thinking about updating my approaches (last time I did this I was using HISAT and Cuffdiff). I’d like some opinions on best strategies to disentangle/filter out parasite microbe reads from infected host reads before preforming a differential gene…

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STAR alignment speed

STAR alignment speed 1 Hello, I am trying to align RNA sequencing data from the NCBI SRA database to the Apis mellifera genome with STAR. The alignment worked fine. However, the mapping step of the alignment seems to be a bit slow. Furthermore, increasing the number of available threads does…

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Google introduces Lyria, the music-generating AI model

Tech & Startup Desk Mon Nov 20, 2023 09:37 AM Last update on: Mon Nov 20, 2023 12:22 PM The prompt screen of Google Deepmind’s Lyria. Image: Google Deepmind “> The prompt screen of Google Deepmind’s Lyria. Image: Google Deepmind Google Deepmind, the AI research laboratory owned by Google, has…

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Slurm Shandy @slurmshandy,bsky.social Ad guys be like “i know a spot” and then take you here Nov 14, 2023 at

memepedia log in Animals & Nature Anime & Manga Art & Creative Cars Celebrities Gaming Girls Internet Memes Movies Other Politics Science & Tech Sports TV shows log in add meme new featured top memes memes catalog Animals & Nature Anime & Manga Art & Creative Cars Celebrities Gaming Girls…

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STAR ALIGNMENT

STAR ALIGNMENT 0 Hi, I am running STAR with my human samples, using GRCh38. However, some of my samples got very low alignment rate. Most of the reads are unmapped: too short. Is there any suggestions on how to deal with this? Thanks you so much! alignment rate • 30…

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10 Scientific Discoveries in 2023

Milad Abolhasani, NC State University The end of one year and the beginning of the next always seems to bring a sense of reflection. The passage of time marked by the changing year is a respected and honored milestone in life. How was this year different than last? Did you…

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