Tag: stem

Cultured naïve pluripotent ESC differentiate into first lineage, XEN or second lineage, formative pluripotency. Hyperosmotic stress (sorbitol), like retinoic acid, decreases naive pluripotency and increases XEN in two ESC lines, as reported by bulk and scRNAseq, analyzed by UMAP. Sorbitol overrides pluripotency in two ESC lines as reported by bulk…

The report highlights the main discoveries and insights derived from the in-depth research conducted on the global CRISPR Cas9 market. It outlines the significant trends, growth drivers, and challenges observed in the industry, providing valuable information for stakeholders.  Introduction: The introduction part provides as a first summary of the global…

FDA Approves Novel Cyclosporine for Dye Eye Disease The FDA has approved Novaliq’s Vevye (cyclosporine) 0.1% to treat patients with dry eye disease. Vevye (which had development name CyclASol) is a water-free, preservative-free solution based on EyeSol technology. Cyclosporine is not water-soluble, but the EyeSol excipient perfluorobutylpentane allows for improved bioavailability…

A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology. Studying stem cell samples from hundreds of individuals in the same culture dish, using a method developed at the Garvan Institute of Medical Research, could have transformative potential for personalised treatments and…

Figure 5 Detection and labeling techniques in immortal cell lines. In the immortal cell lines,… Figure 5 Detection and labeling techniques in immortal cell lines. In the immortal cell lines, BRET, FRET and PCA were used for detection of GPCR-related protein interactions. In BRET, classical ones included Gα/Gβγ or GPCR dimer…

Review . 2023 Jun;41(S1):107-111. doi: 10.1002/hon.3154. Affiliations Expand Affiliation 1 Department of Haematology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark. Item in Clipboard Review Martin Hutchings. Hematol Oncol. 2023 Jun. Show details Display options Display options Format AbstractPubMedPMID . 2023 Jun;41(S1):107-111. doi: 10.1002/hon.3154. Affiliation 1 Department of Haematology, Rigshospitalet, University…

By MaryAnn Labant Back in 2016, a group of researchers led by Harvard’s David Liu, PhD, published a paper in Nature that reported the development of base editing. Base editing, they wrote, is “a new approach to genome editing that enables the direct, irreversible conversion of one target DNA base…

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000…

An improvement in minimal residual disease (MRD)-negative complete remission (CR) rate was observed with ponatinib (Iclusig) plus reduced-intensity chemotherapy vs imatinib (Gleevec) plus reduced-intensity chemotherapy in newly diagnosed patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). Findings come from the phase 3 PhALLCON trial (NCT03589326) which were presented at…

NEW YORK – Investigators in Iceland, Singapore, and Spain have identified common genetic variants contributing to voice pitch in a speech-focused genome-wide association study conducted in thousands of Icelanders. The team’s findings, published in Science Advances on Friday, provided a look at the physical, cognitive, and physiological features influencing voice…

PRESS RELEASE Published June 9, 2023 The Latest Research Report on Fanconi Anemia Market 2023 covering the micro level of analysis by competitors and key business segments. The Global Fanconi Anemia explores an inclusive study on various segments like growth drivers, opportunities, market size, shares, development, innovation, sales, and overall…

On June 9, 2023, Vertex Pharmaceuticals and CRISPR Therapeutics jointly announced that they have submitted Biological License Applications (BLAs) to the FDA for exagamglogene autotemcel (exa-cel) to treat sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The innovative treatment uses CRISPR technology to edit a patient’s hematopoietic stem cells, enabling…

Allikmets, R. et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat. Genet. 15, 236–246 (1997). Article  CAS  PubMed  Google Scholar  Tanna, P., Strauss, R. W., Fujinami, K. & Michaelides, M. Stargardt disease: Clinical features, molecular genetics, animal models and therapeutic options. Br….

Credit: Marcin Klapczynski / iStock A “village” approach that cultures cells from hundreds of people simultaneously could provide new insights into how genetics affect disease and drug treatment response, researchers say. The village system involves culturing and differentiating cells from multiple donor individuals in a single dish, then analyzing using…

LAUSANNE, Switzerland, June 09, 2023 (GLOBE NEWSWIRE) — ADC Therapeutics SA (NYSE: ADCT) today announced updated results from LOTIS-2, the pivotal Phase 2 clinical trial of ZYNLONTA® (loncastuximab tesirine-lpyl) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The data are being presented in a poster today at the European…

18 The news comes from Frankfurt, where the annual Congress of the European Hematology Association (EHA) is underway, that a 6-year-old Italian boy with beta-thalassemia will receive autologous cell therapy next Tuesday which will allow him to grow without having to have blood transfusions as patients with this blood disease…

What is DNA Sequencing? DNA sequencing is a fundamental process that involves determining the precise order of nucleotides in a DNA molecule. The nucleotides, namely adenine, guanine, cytosine, and thymine, make up the genetic code and provide vital information about an organism’s traits and characteristics. With the advent of rapid…

A. 66766 Ph: 250-727-ARRHYTHMIA 4461 Ph: 250-727-4461PROGRAM QT Prolonging Drugs-Alternatives Below is a list of alternatives to some QT prolonging drugs. 2006 Jul;80(1):61-74. The latest study to confirm this connection came out in June 2019 in the Journal of the American Medical Association (JAMA). Copyright 2023 by RxList Inc. An…

Only 19% to 26% of patients with chronic myeloid leukemia (CML) discuss treatment decisions with their physician, a survey by Swiss-based pharmaceutical Novartis has revealed. The Survey of Unmet Needs in CML (CML SUN), which investigated how patients and physicians felt about current treatment options, joint decision-making, and treatment satisfaction,…

Media Release COPENHAGEN, Denmark; June 9, 2023, at 9:00am CEST Results from phase 1/2 EPCORE™ NHL-2 trial investigating epcoritamab in combination with rituximab-lenalidomide (R2) showed a 98 percent overall response rate (ORR), 87 percent complete metabolic response (CMR) in patients with relapsed or refractory (R/R) follicular lymphoma (FL) Results from…

COPENHAGEN, Denmark–(BUSINESS WIRE)– Genmab A/S (Nasdaq: GMAB) today announced data from its ongoing phase 1/2 EPCORE™ NHL-2 trial investigating epcoritamab, a T-cell engaging bispecific antibody administered subcutaneously, in combination with rituximab-lenalidomide (R2) showed an overall response rate (ORR) of 98 percent and complete metabolic response (CMR) of 87 percent in…

Summary The Dang Laboratory at the Huffington Center on Aging, Baylor College of Medicine investigates the roles of epigenetics and chromatin dynamics in regulating aging, with an emphasis on cellular aging and mammalian adult stem cell aging. We are looking for a Postdoctoral Associate with training in bioinformatics and…

UK-based Higher Steaks has rebranded as Uncommon and raised $30 million in a series A round to scale production of cultivated pork using patent-pending technology it claims gives it a competitive edge by speeding up the cell differentiation process. The funding round was led by Balderton Capital and Lowercarbon Capital,…

Ikhaya » Microbiology » Ufuzo Advertisements HSP umgqugquzeli we-strand esindayo I-LSP ukukhanya strand umgqugquzeli MGME1 i-mitochondrial genome maintenance exonuclease 1 mtSSB I-mitochondrial enemicu eyodwa ye-DNA-binding protein NCR isifunda esingabhali ikhodi I-TAS ukulandelana okuhlobene nokuqedwa I-Mitochondrial DNA (mtDNA) iyi-molecule eyi-16.6 kilobase enemicu ephindwe kabili. Umucu owodwa we-DNA ye-mitochondrial inothe ngama-guanines, okuvumela…

Dermal cell characterization by 10X scRNA-seq. a, Workflow used to obtain dermal cells of adult and aged mouse back skin. Single-cell suspensions were enriched separately for EpCAM–CD45– and CD45+ cells by FACS. Transcriptomes of sorted single cells were then analyzed by 10X scRNA-seq. For CD45+ cells, n = 7 mice for the adult…

UK life sciences in search for AI, digital and data talent The UK biopharmaceutical industry is increasingly seeking talent with AI and data skills in order to remain competitive as digital technology drives innovations, according to a new Association of the British Pharmaceutical Industry (ABPI) report. The pharmaceutical industry is…

Variation and evolution in Setaria We collected genome-wide resequencing data for 630 wild (S. viridis), 829 landrace and 385 modern cultivated accessions from the Setaria genus with an average sequencing depth of ~15×, of which 1,004 were newly generated and 840 were from previous studies16,21 (Supplementary Table 1). After aligning…

2.1. Specificity SnoRNAs are ubiquitous and highly abundant RNAs [21,28]. So, how can one target the malignant cell with little to no harm to healthy cells? Recent publications have demonstrated that some rRNA modifications occur in sub-stoichiometric levels [10,29]. This finding has overturned the notion that all rRNA modifications are…

John M. Perry1 and Linheng Li1,2,3 1 Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; 2 Department of Pathology, Kansas University Medical Center, Kansas City, Kansas 66160, USA Abstract Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and…

An extensive study of the market’s trends, drivers, challenges, and opportunities is one of the services highlighted in the global CRISPR-Cas9 Nuclease market research. Insights into the industry’s competitive environment, major market players, and their tactics for gaining an advantage over rivals are also provided in the study. The report…

Global “Mice Model Market” is an exploration report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. These bits of knowledge offered in the Mice Model Market report would…

Axol Bioscience Ltd. (Axol), a leading pluripotent stem cell technology provider for drug discovery has signed an exclusive agreement with StrataStem to access and commercialize its extensive collection of Alzheimer’s Disease (AD) patient samples. Harnessing its stem cell expertise, Axol will reprogram these patient samples into induced Pluripotent Stem Cells…

Clinical stage biomedical company ProtoKinetix Incorporated (OTCMKTS:PKTX) was in the news cycle on Tuesday after it made a significant new announcement. The company revealed that it had submitted a research paper which described cell characterization, graft evaluation and yield islet like cells which could be used for the treatment and…

Cardiovascular disease is a general term used to describe a disease that affects the heart and blood vessels. According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death globally, with statistics from 2019 stating that an estimated 17.9 million people died from some type of…

Spanish-headquartered Minoryx Therapeutics says the U.S. Food and Drug Administration (FDA) has approved its phase 3 clinical trial (CALYX) of lead candidate leriglitazone, to treat adult male X-linked adrenoleukodystrophy (X-ALD) patients with cerebral adrenoleukodystrophy (cALD).  X-ALD is an orphan neurodegenerative disease. The global incidence of X-ALD is approximately six to…

Companies will incorporate cells and technology to create a ‘clinical trial in a dish’ Axol Bioscience – a stem cell technology provider – has reached an agreement with StrataStem to access and commercialise its collection of Alzheimer’s disease (AD) patient samples. Under the terms, Axol will reprogramme…

Please help us protect Glassdoor by verifying that you’re a Dunja Ferring-Appel landed a job as a research technician at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in 2002. Gender Pay Gap, Caso continue recebendo esta mensagem, para nos informar sobre o problema. Ci New Germany is a…

– Advertisement – An international team led by KAUST’s Magdy Mahfouz and Khalid Sedeek has shown that desirable agronomic traits of shorter stem length and early maturity can be introduced into black rice, which is known to be more nutritious than white rice. The researchers gathered comprehensive genomic information and…

The US Food and Drug Administration (FDA) has approved letermovir (Prevymis) for the additional indication of prevention of cytomegalovirus in high-risk adult kidney transplant recipients.  The approval for CMV disease prophylaxis in adult kidney transplant recipients is based on a phase 3 trial of the drug, published this week in…

Europe AI in Bioinformatics Market Scope and Overview: The reduction in the genetic sequencing cost has enhanced the demand of the market. The rising healthcare expenditure for better health services is also attributed to the growth of the market. The major market players are highly focused on various service launches and service approvals during…

RESEARCH HIGHLIGHT 07 June 2023 Regenerative cell-based therapies derived from induced pluripotent stem cells (iPSCs) have the potential to treat diseases involving the loss of specialized cells, such as type 1 diabetes. However, the host immune response presents a critical impediment to achieving efficient survival, engraftment and long-term functionality of…

uBriGene has years of experience in developing cell therapy products, manufacturing GMP cell therapy products and well-rounded QA and QC systems to meet regulatory requirements. We provide clients with CDMO services such as stem cell production technique development, manufacturing, quality testing, and IND application documentation. We provide one-stop services including…

Cold Spring Harb Mol Case Stud. 2023 Apr; 9(2): a006256. ,1,2 ,1,2 ,1,2 ,2,3 ,4 and 1,2 Mahvish Q. Rahim 1Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA; 2Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, USA; April Rahrig 1Pediatric Hematology Oncology,…

Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide. While the human genome comprises coding and non-coding…

Superior global cognition in the oldest-old was associated with resistance to neurodegenerative pathologies, autopsy data showed. (Journal of Alzheimer’s Disease) Brain network models showed that people with higher intelligence scores took more time to solve difficult problems, and that slower solvers had higher average functional connectivity. (Nature Communications) The novel…

Viral Vector & Plasmid DNA Manufacturing Market Newark, New Castle, USA: The “Viral Vector & Plasmid DNA Manufacturing Market” provides a value chain analysis of revenue for the anticipated period from 2023 to 2031. The report will include a full and comprehensive analysis of the business operations of all market…

General structure, organization, and composition of mitogenomes The gene order and arrangement characteristics of the twelve mitogenomes in the present study (Chironomus kiiensis, Chironomus nipponensis, Chironomus plumosus, Dicrotendipes pelochloris, Dicrotendipes sp., Einfeldia sp., Glyptotendipes tokunagai, Limnophyes sp., Nilodorum tainanus, Polypedilum nubifer, Smittia aterrima, and Tanytarsus formosanus) were similar to those…

I’m Dr. Neville Sanjana, human geneticist. Today I’ll be taking your questions from Twitter. This is Genetics Support. [upbeat music] @SortOfKnownO asks, Someone explain Lenny Kravitz to me, please. I’d like to understand how his genes work. How is he still this hot? I’m not sure there’s a gene for…

Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide. While the human genome comprises coding and non-coding…

The Importance Of Biotech And Healthcare Biotech and healthcare are massive parts of our economy. They are also literally vital to us whenever our bodies suffer from injuries, diseases, or other medical issues. It is also a sector driven by innovation and precious IPs, where thriving for new and improved…

The FDA has approved a new indication for letermovir for prophylaxis of CMV disease in adult kidney transplant recipients at high risk (Donor CMV-seropositive/Recipient CMV-seronegative [D+/R-]). Letermovir is a first-in-class non-nucleoside that inhibits viral replication by specifically targeting the viral terminase complex. “Prevymis has been an important addition to the…

In celebration of Pride Month and launched with the goal of connecting LGBTQIA+ youth with role models in various STEM fields, UConn’s Second Annual Queer Science Conference was held on Sunday, June 4, at the Storrs Campus. The one-day, volunteer-driven event – entirely free for participants – connected high school…

The drug, an injectable called cisplatin, is prescribed for up to 20% of all cancer patients, according to the National Cancer Institute. The FDA is also allowing the resumption of cancer drug imports from an Indian manufacturer with a history of inspection problems. USA Today: U.S. To Import Chemotherapy Drug…

DOI: 10.18129/B9.bioc.peco     This package is for version 3.13 of Bioconductor; for the stable, up-to-date release version, see peco. A Supervised Approach for **P**r**e**dicting **c**ell Cycle Pr**o**gression using scRNA-seq data Bioconductor version: 3.13 Our approach provides a way to assign continuous cell cycle phase using scRNA-seq data, and consequently,…

APPLICATION CLOSING DATE:  30th of June 2023 Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian government, with the aim of developing innovative strategies to improve human health. In this context the Giustacchini group at the Population and Medical Genomics Centre is looking for a…

Introduction Primary testicular lymphoma, which accounts for less than 2% of non-Hodgkin lymphoma (NHL) cases, has similarities to extra-nodal NHL that occurs in immune-privileged sites, such as the eye and central nervous system (CNS).1 Pathologically, 80–90% of primary testicular lymphoma cases demonstrate diffuse large B-cell lymphoma (DLBCL) with non-germinal center/activated…

Credit: SERGII IAREMENKO / Getty Images A little over a decade ago, a paper was published in Science1  that made science fiction a reality. Emmanuel Charpentier, Jennifer Doudna, and colleagues reported that they had identified a means of harnessing an element of a bacterial immune system to carry out genome…

Pigmented rice, such as black, brown, and red rice, is rich in essential microelements, including iron, zinc, copper, manganese, and selenium. Credit: © 2023 KAUST; Khalid Sedeek. KAUST researchers are working to improve the agronomic traits of pigmented rice varieties using genomic studies and CRISPR technology. Their focus is on…

SAN DIEGO, June 5, 2023 /PRNewswire/ — Illumina Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, today published its annual Corporate Social Responsibility (CSR) Report, highlighting the company’s commitment to human health, and the progress made by its environmental, social, and governance (ESG) program in 2022….

mRNA-4157 (V940) in combination with KEYTRUDA reduced the risk of distant metastasis or death by 65% (HR=0.347 [95% CI, 0.145-0.828]); one-sided p value=0.0063) compared to KEYTRUDA alone The DMFS results, a key secondary endpoint of the Phase 2b KEYNOTE-942 study, will be presented at the 2023 American Society of Clinical…

Patients treated with dual immunotherapy-based combination demonstrate sustained clinical benefits after four years vs. chemotherapy alone, with magnitude of benefit more pronounced amongst patient subgroups with high unmet needs Late-breaking data to be presented during the 2023 American Society of Clinical Oncology Annual Meeting PRINCETON, N.J., June 04, 2023–(BUSINESS WIRE)–Bristol…

Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene, resulting in death by the end of the third decade of life at the latest. A key aspect of the DMD clinical phenotype is dilated cardiomyopathy, affecting virtually all patients by the…

WGCNA Trait File Issues 1 I have RNASeq data that I am trying to use for WGCNA. However I am running into downstream issues that I believe stem from my trait file. I have 24 samples, 3 replicates of 8 different treatment groups. I am trying to follow the WGCNA…

PRINCETON, N.J.–(BUSINESS WIRE)–Jun 4, 2023– Bristol Myers Squibb (NYSE: BMY) today announced four-year follow-up results from the Phase 3 CheckMate -9LA trial demonstrating durable, long-term survival benefits with Opdivo (nivolumab) plus Yervoy (ipilimumab) with two cycles of chemotherapy compared to four cycles of chemotherapy alone in previously untreated patients with…

Four-Year Outcomes from Phase 3 CheckMate -9LA Trial Show Durable, Long-Term Survival with Opdivo (nivolumab) Plus Yervoy (ipilimumab) with Two Cycles of Chemotherapy for Patients with Metastatic Non-Small Cell Lung Cancer Details Category: Antibodies Published on Sunday, 04 June 2023 15:16 Hits: 87 Patients treated with dual immunotherapy-based combination demonstrate…

Background: Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle regeneration and improve muscle function, however, the specific molecular mechanisms remain unclear. DMD suffers varying degrees of hypoxic…

Because of its versatile application as a model species in various fields of study, there is a need for a genetic transformation toolkit in narrowleaf plantain (Plantago lanceolata). Here, using Agrobacterium tumefaciens-mediated transformation, a protocol is presented that results in stable transgenic lines with a transformation efficiency of 20%. Plantago…

Peona, V., Weissensteiner, M. H. & Suh, A. How complete are “complete” genome assemblies? An avian perspective. Mol. Ecol. Resour. 18, 1188–1195 (2018). Article  CAS  PubMed  Google Scholar  Peona, V. et al. Identifying the causes and consequences of assembly gaps using a multiplatform genome assembly of a bird-of-paradise. Mol. Ecol….

Introduction Interleukin (IL)-2 was the first Food and Drug Administration approved immunotherapy for use in patients with metastatic melanoma and renal cell carcinoma.1 2 However, the use of recombinant IL-2 (Proleukin/aldesleukin) has been problematic due to low response rates, off-target effects, and severe dose-dependent toxicities. Due to its potent T-cell…

2023 ASCO Annual Meeting Muhit Özcan, MD, of Turkey’s Ankara University School of Medicine, discusses waveLINE-007, a two-part study now recruiting in more than 20 locations, to determine the safety and recommended phase II dose of the antibody-drug conjugate zilovertamab vedotin in combination with R-CHP (rituximab, cyclophosphamide, doxorubicin, prednisone) in…

Wasti S, Sah N, Mishra B. Impact of heat stress on poultry health and performances, and potential mitigation strategies. Animals. 2020;10:1266. doi.org/10.3390/ani10081266. Article  PubMed  PubMed Central  Google Scholar  Lara LJ, Rostagno MH. Impact of heat stress on poultry production. Animals. 2013;3:356–69. Article  PubMed  PubMed Central  Google Scholar  Al-Saffar AA, Rose…

To help public health professionals and others address the needs of persons living or working near hazardous waste sites, the information in this section is organized first by route of exposure (inhalation, oral, and dermal) and then by health effect (death, systemic, immunological, neurological, reproductive, developmental, genotoxic, and carcinogenic effects)….

Fate Therapeutics is looking for a Senior Scientist or Scientist with expertise in bioinformatics to join the Molecular Engineering team.    The primary focus for this position will be to independently develop, optimize, and implement NGS pipelines to support advancement of Fate’s gene editing platform. The position will also establish, modify,…

This H3K9me3 rabbit polyclonal antibody was raised against a modified branched peptide and specifically recognizes histone H3 tri-methylated on lysine 9 (H3K9me3). Highlights: Detects a single protein of approximately 14 kDa by western blot using acid extracted histones Suitable for chromatin immunoprecipitation (ChIP) assays H3K9me3 indicates the addition of a…

Peripheral T-cell lymphomas (PTCLs) represent only 10%-15% of all non-Hodgkin lymphoma but encompass a diverse group of diseases with over 30 different subtypes. As a result of both disease heterogeneity and rarity, therapeutic progress of PTCLs has lagged behind B-cell lymphomas with very few randomized controlled studies to guide management….

Ahemad M, Khan MS (2012) Effect of fungicides on plant growth promoting activities of phosphate solubilizing Pseudomonas putida isolated from mustard (Brassica compestris) rhizosphere. Chemosphere 86(9):945–950. doi.org/10.1016/j.chemosphere.2011.11.013 Article  CAS  PubMed  Google Scholar  Al-Askar AA, Saber WI, Ghoneem KM, Hafez EE, Ibrahim AA (2021) Crude citric acid of Trichoderma asperellum: tomato…

1. The Application of iPSCs to Questions in Virology: A Historical Perspective 2. Transplantation Of iPSCs -Derived Neural Progenitor Cells Promotes Clinical Recovery and Repair in Response to Murine Coronavirus-Induced Neurologic Disease 3. iPSCs For Modeling Influenza Infection 4. Human Induced Pluripotent Stem Cells for Modeling of Herpes Simplex Virus…

Cite Li X., Zhang P., Wei C., Zhang Y. (2014). Generation of pluripotent stem cells via protein transduction. Int. J. Dev. Biol. 58: 21-27. doi.org/10.1387/ijdb.140007XL Related articles …

Transcript Our research focusing on stem cell biology, especially intestinal stem cell, present at the bottom of intestinal crypt. The aim is to answer how homeostasis is maintained by the stem cell in the intestine. This 3D organ culture derived from intestinal stem cell provides a powerful tool to study…

Jaing, T.-H., Chang, T.-Y., Chen, S.-H., Lin, C.-W., Wen, Y.-C., & Chiu, C.-C. (2021). Molecular genetics of β-thalassemia: A narrative review. Medicine, 100(45), e27522. Article  CAS  PubMed  PubMed Central  Google Scholar  Rattananon, P., Anurathapan, U., Bhukhai, K., & Hongeng, S. (2021). The future of gene therapy for transfusion-dependent beta-thalassemia: The…

Great opportunity to contribute to a research project focused the detection and repair of sick retinal ganglion cells Full time, 3 year fixed term Base Salary $113,184 + 17% superannuation About the opportunity The Save Sight Institute (SSI) is a Centre of The University of Sydney,…

New data emphasizes the value of MRD testing in predicting survival outcomes and informing the personalized treatment of patients with hematologic cancers clonoSEQ continues to be the MRD test of choice for biopharma companies as evidenced in over a dozen investigational studies across multiple therapeutic approaches SEATTLE, June 02, 2023…

As biotechs come up with fascinating, new ways to cultivate food, Israel-based Steakholder Foods has created the first-ever 3D-printed fish filets. These ready-to-cook filets, which are developed from animal cells that are grown in laboratories, are obtained from the startup’s proprietary 3D bioprinters and customized bio-inks.  Said to have the…

CAMBRIDGE, Mass., June 01, 2023 (GLOBE NEWSWIRE) — Fujifilm Life Sciences, a broad portfolio of Fujifilm Group operations offering products, services and comprehensive solutions that span support for all stages of therapeutic development from discovery through to commercialization, today announced that it will showcase its offerings across the therapeutics development…

PRESS RELEASE Published June 1, 2023 InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled “Global iPSCs Manufacturing Services Market  (By Application (Research Products, Drug Development & Discovery, Cellular Therapy, Toxicology Screening, Personalized Medicine, Disease Modelling, Stem Cell Banking, Emerging Applications), End-User(Pharmaceutical & Biotechnology Companies,…

An early clinical trial headed by researchers at Keio University School of Medicine has shown that the Parkinson’s disease drug ropinirole is safe to use in patients with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), and delayed disease progression by an average of 27.9 weeks. The study demonstrated…

Photo of iPSCs-derived Motor neurons derived from an ALS patient. Credit: Morimoto et al/Cell Stem Cell Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. There is no cure, and current treatments focus…

TOKYO, Japan — A new study reveals that a common drug for treating Parkinson’s disease, ropinirole, can effectively slow the progression of amyotrophic lateral sclerosis (ALS) for over six months. ALS, which has claimed the lives of countless people, including renowned cosmologist Stephen Hawking, gradually causes people to lose muscle…

Crosby, D. et al. Early detection of cancer. Science 375, eaay9040 (2022). Article  CAS  PubMed  Google Scholar  Vázquez-García, I. et al. Clonal heterogeneity influences the fate of new adaptive mutations. Cell Rep. 21, 732–744 (2017). Article  PubMed  PubMed Central  Google Scholar  Lenski, R. E., Rose, M. R., Simpson, S. C….

Data published online in the journal Cytotherapy demonstrate that CRISPR-mediated tissue factor gene knockout (TFKO) in allogeneic stromal cells (ASCs) leads to significantly lower tissue factor (TF) expression, activity, and thrombotic effects, providing a feasible strategy potentially to improve the safety of ASC-based cell therapy FLORHAM PARK, N.J., June 01,…

Celularity Inc. (Nasdaq: CELU) (“Celularity”), a biotechnology company developing placental-derived allogeneic cell therapies and biomaterial products, announced today the online publication of preclinical data in Cytotherapy, the official journal of the International Society of Cell and Gene Therapy (ISCT). The paper, “Characterization of CRISPR/Cas9-edited human placental allogenic stromal cells with…

Genome sequencing and assembly We sequenced and assembled genomes for the sandalwood species S. album and S. yasi (Fig. 1). In total, ~23 Gb and ~25 Gb of clean short reads of S. album and S. yasi were obtained for the genomic survey, respectively (Supplementary Tables 1 and 2). According to k-mer analysis, the…

Vaswani, A. et al. Attention is all you need. Preprint at doi.org/10.48550/arXiv.1706.03762 (2017). Devlin, J., Chang, M. W., Lee, K. & Toutanova, K. BERT: pre-training of deep bidirectional transformers for language understanding. In Proc. 2019 Conference North American Chapter of the Association for Computational Linguistics: Human Language Technologies Vol. 1…

ElevateBio, LLC (ElevateBio), a technology-driven company focused on cell and gene therapies, has closed its $401 million Series D financing. “We have made significant strides in scaling our technologies and end-to-end capabilities in our pursuit to become the world’s most indispensable cell and gene therapy technology company. We are thrilled…

Scientists from the University of Barcelona in Spain and the Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre (CIBERobn) have designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy. The technique consists of implanting cells that have been manipulated and transformed in order…

CRISPR-based microbial gene therapy company SNIPR Biome ApS has announced positive interim clinical results from its phase 1 clinical trial with SNIPR001. SNIPR001 is the first CRISPR-armed phage therapeutic developed to specifically target and remove E. coli, including antibiotic-resistant strains, from the human gastrointestinal tract.  The work was supported by…

Abstract Cotinus is an oligo‐specific ornamentally valuable genus with a disjunct distribution in the Northern Hemisphere. Traditionally, the taxonomy of Cotinus was mainly based on leaf morphological characteristics. However, the limited availability of genomic information greatly hindered the study of molecular evolution and phylogeny of this genus. This study sequenced…

In 1998, DNA sequencing and array-based technology provider Illumina launched with the mission of improving human health by unlocking the power of the genome—a bold vision considering the scientific community was still five years away from generating the first sequence of the human genome. That accomplishment, ultimately achieved through a…

PRESS RELEASE Published May 31, 2023 InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the “Global Value-Based Healthcare Services Market By Type (Alkaline Phosphatase Staining Assay, Pluripotency Markers (Protein) And Pluripotency Markers (Mrna)), Application (Cancer Research Center, Pathology Laboratory, Academic And Research, Contract Research Organizations…

Approval of the first-in-class, subcutaneously administered T-cell–engaging bispecific antibody epcoritamab-bysp (Epkinly) provides an effective alternative to chemotherapy for patients with diffuse large B cell lymphoma (DLBCL) in the third-line setting, according to Tycel Phillips, MD. On May 19, 2023, single-agent epcoritamab gained FDA approval for the treatment of patients with…