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Translational Regenerative Medicine market is estimated to grow at a CAGR of 24.3% by 2034: Visiongain
Visiongain Reports Ltd Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS…
Translational Regenerative Medicine market is estimated to
Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS Analysis of Leading…
Topic Modelling with LDA: A Comprehensive Guide for Students
2/8/24, 5:59 PMtopic-modelling-lda.ipynb – Colaboratory 1/5# This Python 3 environment comes with many helpful analytics libraries installed # It is defined by the kaggle/python Docker image: # For example, here’s several helpful packages to load import numpy as np # linear algebra import pandas as pd # data processing, CSV…
Red Genes: Assessing WuXi AppTec’s Ties to the Party-Army-State
Executive Summary: WuXi AppTec, a major Chinese biotechnology and pharmaceutical firm, claimed that the company has not, does not, and will not pose a national security risk to any country in response to new legislation introduced in the US Congress. The company’s claims are undermined by WuXi Apptec’s network of…
All Roads Lead to Genome Editing
Shondra Pruett-Miller, a biochemist at St. Jude Children’s Research Hospital, found her calling during her first year of graduate school at the University of Texas, Southwestern. In 2003, during the departmental faculty research talks, she watched with excitement as Matthew Porteus, now a biochemist at Stanford University, presented his research…
A Method to Obtain CTCs from Murine Colorectal Cancer Model
– Circulating Tumor Cells, or CTCs, are the cancer cells that stem from the primary tumor and enter the blood circulation. Most CTCs can survive in the bloodstream without attaching to the surface; therefore, we can detect them directly from the blood of most cancer patients. CTCs in the blood…
what is in the pipeline?
According to the World Health Organization (WHO), around 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally. Although treatments are already available for the disease – which include narrow-spectrum anti-epileptic drugs (AEDs) to treat specific types of seizures, and broad-spectrum AEDs to treat…
Can gene therapy be the key to restoring hearing loss?
Gene therapy has had a number of success stories with regards to treating blood disorders like hemophilia and beta-thalassemia, as well as in cancer research. Now, the latest breakthrough in gene therapy has been in restoring hearing loss in an 11-year-old boy. A team of scientists at the Children’s Hospital…
This new approach could revolutionize knee osteoarthritis treatment
BioSenic, a clinical-stage Belgian-headquartered company specializing in serious autoimmune and inflammatory diseases and cell therapy, will be sharing data on its late-clinical asset JTA-004 for the treatment of knee osteoarthritis at the Osteoarthritis Research Society International (OARSI) World Congress 2024. The event takes place in Vienna, Austria, from April 18…
16 UK biotech companies you should know about
The UK is home to several biotech hubs, including the famous ‘golden triangle’, made up of Oxford, Cambridge, and London. In fact, after a $700 million surge in funding in the third quarter of 2023, the UK biotech scene is now one of the most vibrant in Europe, laying the…
Top antibody-drug conjugate (ADC) companies leading the industry
The antibody-drug conjugate (ADC) field is witnessing an expansion in the variety of conjugation techniques, linker chemistry, and payloads being used, moving beyond traditional tubulin inhibitors to include novel mechanisms of action. Investments in ADC research continue to grow, with significant funding rounds and acquisitions. For example, Novo Holdings’ $105…
What is shrna transfection? | 4 Answers from Research papers
What are the applications of gene transfer in the treatment of various diseases?5 answersGene transfer has various applications in the treatment of different diseases. It can be used for gene therapy, where new genes are inserted into cancer cells to slow down their growth or induce cell death. Gene transfer…
Study Highlights Treatment Patterns, Costs for DLBCL Not Treated With Stem Cell Transplant
New research highlights treatment patterns, health care resource utilization (HCRU), and costs associated with patients who have diffuse large B-cell lymphoma (DLBCL) who did not undergo stem cell transplantation in the second-line setting between 2009 and 2020. Of a 750-patient cohort, 86.8% received rituximab plus cyclophosphamide, doxorubicin, vincristine (Oncovin), and…
New Opportunities for Human Stem Cells in Research and Clinical Applications
About iPSCs (induced pluripotent stem cells), an inexhaustible source of functional human cells, have enormous potential for biomedical research and health care. They are being used to study genetic disease, new drug development, and treatment of a broad range of disorders — diabetes, cancer, neurological illnesses, and more. This forum…
IPSCs used to study common genetic cause of chILD
Researchers observed many quantifiable differences between diseased cells made from affected children and their gene-edited cells. Researchers from the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center and collaborators at Washington University School of Medicine have shown how they can now study the most common genetic…
Unleashing the Potential of Induced Pluripotent Stem Cells (iPSCs)
Unleashing the Potential of Induced Pluripotent Stem Cells (iPSCs) Induced pluripotent stem cells (iPSCs) represent a groundbreaking scientific discovery with vast potential for biomedical research and healthcare. These cells, which can be generated from a patient’s own tissues, can differentiate into any cell type in the body, thus providing an…
Causality-enriched epigenetic age uncouples damage and adaptation
Gladyshev, V. N. et al. Molecular damage in aging. Nat. Aging 1, 1096–1106 (2021). Article PubMed PubMed Central Google Scholar Sziráki, A., Tyshkovskiy, A. & Gladyshev, V. N. Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell 17, e12738 (2018). Article PubMed …
Ten NK cell therapy companies to look out for this year
Natural killer (NK) cells are white blood cells that are a part of the body’s defense mechanism. These cells are on the lookout for any kind of disruption in the immune system, and can kill diseased cells like tumor cells. NK cells are being used in clinical applications to treat…
when brain organoids meet AI for disruptive progress
It was in the early 2010s when researchers laid the foundation for brain organoids developed from stem cells. Now, more than a decade later, they have been used to power Brainoware, a biohybrid computer that can perform speech recognition tasks. This computer is like no other, as it combines a…
The future of diabetes treatment: Is a cure possible?
Diabetes has become an epidemic, sentencing over 537 million people worldwide to lifelong medication. Science is striving to find a diabetes treatment that can cure this chronic disease, but how close are we? Diabetes is the major cause of blindness, kidney failure, heart attack, and stroke. It is estimated that…
could it be a cure?
When CASGEVY, the first CRISPR-based therapy, was approved by the FDA in December, it gave CRISPR technology the validation it needed. Any promise it had held before that moment was simply investigational. In this case, the approval of CASGEVY was granted for the treatment of two blood disorders – sickle…
Stochastic biological system-of-systems modelling for iPSC culture
Cell proliferation and aggregation dynamics modeling The aggregation process is characterized by the dynamic evolution of a density profile of aggregates. Let \(\phi (x,t)\) denote the average number of aggregates or clusters of size \(x\) (i.e., mass and volume) at time \(t\), where mass is equal to a buoyant density…
Cell and Gene Therapies in Japan and Beyond: A Deep Dive
A Look at Cell and Gene Therapies in Japan and Beyond Over the past few years, there has been a growing focus on cell and gene therapies worldwide, with Japan leading the way in their approval. The complex process of such therapies’ approval involves several stages, including randomized clinical trials…
Multiple Job openings at Gujarat Biotechnology Research Centre
Government of Gujarat has established Gujarat State Biotechnology Mission (GSBTM) as a nodal agency to develop overall development of biotechnology in the state in 2004. Major activities of GSBTM is promoting research and development in the field of biotechnology and supporting the development of biotechnology industries in the state. Besides…
CRISPR Therapeutics Highlights Strategic Priorities and
ZUG, Switzerland and BOSTON, Jan. 08, 2024 (GLOBE NEWSWIRE) — CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today highlighted its strategic priorities and 2024 outlook as the Company enters its next phase of growth. “We had a landmark year in 2023, marked…
The best countries for biotech according to the OECD
The OECD recently published an update on key biotechnology indicators, an opportunity for us to delve into the top-performing countries in the field. With the highest number of active biotech companies (2,840) and an R&D intensity added value of 17%, the U.S. remains a strong leader in the industry. But…
What is Anaplastic Large Cell Lymphoma?
Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin’s lymphoma (NHL), a group of blood cancers that affect while blood cells called lymphocytes. With NHL, the lymphocytes grow out of control. These cells are a part of the immune system which helps protect your body from germs and…
Middle East and Africa Induced Pluripotent Stem Cells (iPSCs) market 2023-2030
Market Overview The Middle East and Africa (MEA) region is witnessing significant advancements in the field of regenerative medicine, particularly in the area of induced pluripotent stem cells (iPSCs). iPSCs are derived from adult cells and possess the remarkable ability to differentiate into various cell types, making them a valuable…
Cost and Benefit: Lisocabtagene Maraleucel is Cost Effective as Second-line Treatment for Lymphoma
Lisocabtagene maraleucel (liso-cel; Breyanzi®; Bristol-Myers Squibb), a CD19-directed genetically modified autologous T-cell immunotherapy, also known as chimeric antigen receptor (CAR) T-cell therapy, is a cost effective second line treatment for relapsed and refractory diffuse large B-cell lymphoma (r/r DLBCL). This conclusion is based on results from a study published in…
Anti-EpCAM (Extracellular region) Antibody | Scientist.com
Anti-EpCAM (Extracellular region) Antibody | Scientist.com Skip to Main Content Go to Main Navigation Form: Protein G Purified Gene: EPCAM Host: Mouse Rrid: AB_3068418 Type: Primary Antibody Clone: M039 Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol Target: EpCAM (Extracellular region) Isotype: IgG1 Storage: Storage at -20°C…
Spatial, temporal and reversible regulation of endogenous gene in vivo using RNA interference
Abstract RNA interference is a powerful tool for controlling gene expression in mammalian systems; as such, it has become an effective alternative to conventional knockout approaches. RNAi has proven to be an efficient method to inhibit tumor suppressor gene function and yield insight into the important players in cancer biology….
Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis
Brent, G. A. Mechanisms of thyroid hormone action. J. Clin. Invest. 9, 3035–3043 (2012). Article Google Scholar Iwen, K. A., Oelkrug, R. & Brabant, G. Effects of thyroid hormones on thermogenesis and energy partitioning. J. Mol. Endocrinol. 60, R157–R170 (2018). Article PubMed CAS Google Scholar Biondi, B. & Wartofsky, L….
FDA approves two gene therapy treatments for sickle cell disease
Two new gene therapies to treat sickle cell disease were approved by the U.S. Food and Drug Administration Dec. 8. The treatments, both produced by Boston-area companies, join 32 other approved gene therapies and are approved to treat the disease in the United States. Experts say the developments are a…
Galaxy Newsletter: December 2023 – Galaxy Community Hub
Hello, Galaxy Community! Firstly, the Galaxy team would like to extend our warmest wishes to you and all your loved ones this holiday season! With the New Year rapidly approaching, we wanted to thank you all for being a part of the Galaxy Community in 2023; we couldn’t do it…
MAVS found to antagonize human stem cell senescence as a mitochondrial stabilizer
MAVS maintains mitochondrial homeostasis and regulates cellular senescence through stabilizing OPA1. A. Depletion of MAVS accelerates cellular senescence of human mesenchymal stem cells. B. MAVS deficiency compromises mitochondrial dynamics. C. A model illustrating the MAVS-OPA1 axis regulates mitochondrial homeostasis and human stem cell senescence. Credit: Research A recent study led…
The top biotech breakthroughs that defined 2023
As we look back at 2023 it is clear that the year has been marked by steady progress and notable breackthroughts in the biotech industry. From advancements in Alzheimer’s disease treatments to new approaches in cancer therapy, artificial intelligence (AI) progression, and obesity management, this year has seen important steps…
Researchers look for ways to lower neuroinflammation
Share on PinterestResearchers are looking for more effective ways to deliver a potential therapy against neuroinflammation to the brain. Image credit: Maskot/Getty Images. Small interfering RNAs can silence the machinery that translates certain mRNAs, meaning they can also be used to stop the production of some proteins. Researchers have looked…
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury | Military Medical Research
Animals C57BL/6-Tg (Pf4-icre) Q3Rsko/J (Pf4-Cre) mice were purchased from the Jackson Laboratory (Bar Harbor, ME, USA). B6;129-Tmem173tm1(flox)Smoc (Stingfl) mice were purchased from Shanghai Model Organisms Center, Inc. (Shanghai, China). C57BL/6J-Ifnar1em1(flox)Cya (Ifnar1fl) mice were purchased from Cyagen Biosciences (Guangzhou, China). Stingcko and Ifnar1cko mice were generated by crossing Pf4-Cre mice with…
Molecular characterization of a tetra segmented ssDNA virus infecting Botrytis cinerea worldwide | Virology Journal
Analysis of the multisegmented nature of BcssDV1 genome B. cinerea field isolates were previously obtained from infected grapes of vineyards of Italy and Spain and their mycovirome was determined [8]. A new ssDNA virus (BcssDV1, Genbank accession no. MN625247) was discovered and characterized. The sequence previously characterized of BcssDV1 (from…
UChicago Medicine experts showcase blood cancer research at 65th ASH Annual Meeting
Faculty and trainees from the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) joined the world’s largest hematology community to discuss the latest updates in blood cancers at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition held December 9-12, 2023 in San Diego and online. At the meeting,…
Characteristics of Amorphophallus konjac as indicated by its genome
Genome assembly and annotation The DNA sequencing data (1119.58 Gb, average 110× coverage) of the A. konjac sample were obtained using the Illumina Hiseq 2500 sequencer. A summary of the sequence data used for the assembly is presented in Table S1. The estimated genome size is 4,512,012,462 bp using 19-mer frequency distribution based…
Promoting Neuroscience Research with Creative Biolabs’ Neuronal Differentiation Technologies
PRESS RELEASE Published December 18, 2023 Creative Biolabs, a leading biotechnology company, is proud to announce the launch of its cutting-edge neuronal differentiation technologies, designed to propel scientific research in the fields of neurobiology, regenerative medicine, and drug discovery. New York, USA – December 18, 2023 – Advances in neuroscience…
Casgevy, sickle cell gene-editing therapy, favored for EU approval
A European Medicines Agency committee has issued a positive opinion on the gene-editing therapy Casgevy (exagamglogene autotemcel) in treating sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). The Committee for Medicinal Products for Human Use (CHMP) recommendation will be considered by the European Commission in making a final approval decision…
Darzalex Faspro combo of help with multiple myeloma diagnosis, transplant
Adding Darzalex Faspro (daratumumab and hyaluronidase) — a subcutaneous or under-the-skin formulation of Darzalex (daratumumab) — to a standard combination therapy regimen led to significantly better outcomes for people who are newly diagnosed with multiple myeloma and transplant eligible. That’s according to four-year data from the Phase 3 PERSEUS (NCT03710603) clinical…
FDA approved treatments use gene therapy to help patients with sickle cell disease
By Olivia Trani The U.S. Food and Drug Administration recently approved two gene therapies, Casgevy and Lyfgenia, to treat sickle cell disease in people ages 12 and older. One of the therapies, Casgevy, use a novel gene-editing technique called CRISPR/Cas9, which can modify a cell’s DNA at a targeted location…
Vertex (VRTX), CRISPR Get Positive CHMP Opinion for Gene-Therapy
Vertex Pharmaceuticals Incorporated VRTX announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (“EMA”) had adopted a positive opinion, recommending the conditional approval of Casgevy to treat severe sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). The CHMP’s recommendation, although not legally binding, will…
python – Different results PyTorch vs Libtorch
I am trying to calculate a disparity image for the same traced model in python and c++ but I am getting different outputs. I tried and follow the same steps in c++ as in python but it seems I missed something. I am using the mono_640x192 pretrained model. Here is…
2 Stocks Profiting from Unstoppable Trends That Can Make You Rich The Motley Fool
Sometimes trends are short-term, and as a long-term investor, you probably won’t want to pay too much attention to them. But some trends, because of their potential to change the way things are done for the better, are worth a second look – and even investment. Today, both artificial intelligence…
Illumina, Structure Therapeutics, Point news
Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Today, we see a small biotech on the verge of ending a rare-disease program thanks to FDA difficulties — and how that impacts patients. We fete the best of…
Gene Editor to Treat Blood Diseases
The European Medicines Agency (EMA) has recommended granting conditional marketing authorization for Casgevy (exagamglogene autotemcel) for the treatment of transfusion-dependent beta-thalassemia and severe sickle cell disease in patients 12 years or older who are appropriate candidates for hematopoietic stem cell transplantation but a suitable donor is not available. The treatment…
CHMP recommends gene therapy for beta thalassemia and sickle cell disease
The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended approval of Vertex Pharmaceuticals and CRISPR Therapeutics’ Casgevy (exagamglogene autotemcel) to treat transfusion-dependent beta thalassemia (TDT) and severe sickle cell disease (SCD). SCD and beta thalassemia are genetic conditions caused by errors in the gene…
Sickle cell triumph raises questions
In the realm of genetic manipulation, Crispr technology emerges as a double-edged sword. Enabling precise gene editing, it holds promise for eradicating diseases like sickle cell through treatments like Casgevy. Yet, with the power to shape the very fabric of life, ethical concerns loom large. While some foresee a future…
Vertex secures CHMP approval for Casgevy approval in Europe
Casgevy became first FDA-approved medicine to use CRISPR/Cas9 gene-editing technology. Image credit: Shutterstock/Nemes Laszlo. Vertex Pharmaceuticals has gained a positive opinion from the EMA’s CHMP for Casgevy (exa-cel), paving the way for European approval of the sickle cell gene therapy early next year. The CHMP will now send their recommendation…
Single-cell RNA-seq workflow
In this tutorial we walk through a typical single-cell RNA-seq analysis using Bioconductor packages. We will try to cover data from different protocols, but some of the EDA/QC steps will be focused on the 10X Genomics Chromium protocol. We start from the output of the Cell Ranger preprocessing software. This…
Sample Preparation Products For Next Generation Sequencing Market Size Report 2024-2031 | 113 Pages Report
(MENAFN– The Express Wire) Global “Sample Preparation Products for Next Generation Sequencing Market” report identifies important segments and dynamics, categorizing information to enhance investor comprehension with |113 pages| Medical Devices and Consumables| category report which provides insights into the concentration rate of raw materials in the Sample Preparation Products for…
DNA Sequencing Equipment Market Size, Share, Growth | Research Report [2031]
(MENAFN– The Express Wire) Global “DNA Sequencing Equipment Market” report identifies important segments and dynamics, categorizing information to enhance investor comprehension with |98 pages| Medical Devices and Consumables| category report which provides insights into the concentration rate of raw materials in the DNA Sequencing Equipment Market, the proportion of manufacturing…
Study finds revolutionary cancer vaccine simultaneously kills and prevents brain cancer
[Dec. 17, 2023: JJ Shavit, The Brighter Side of News] Dual action cell therapy is engineered to eliminate established tumors and train the immune system to eliminate the primary tumor and prevent cancer recurrence. (Credit: Creative Commons) In a bold effort to rewrite the story of cancer treatment, scientists are…
[PDF] A Scalable, Off-the-Shelf, and Cost-Effective NK Cell Manufacturing Platform for Developing NK Cell-Based Immunotherapy
Natural killer (NK) cells are innate lymphocytes that play a key role in the control of infection and malignancy. NK cells are potent killers of target cells and act in an MHC-independent manner, enabling their application as allogenic therapy for cancer. Human iPSCs are pluripotent with the ability to self-renew,…
Metagenome analyses identify human endogenous retrovirus-K113 (HML-2) subtype in glioblastoma
. 2023 Dec 15;133(24):e173959. doi: 10.1172/JCI173959. Item in Clipboard Amanda Macamo et al. J Clin Invest. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 Dec 15;133(24):e173959. doi: 10.1172/JCI173959. Item in Clipboard Cite Display options Display options Format AbstractPubMedPMID No abstract available Keywords: Brain cancer; Oncology; Virology. PubMed Disclaimer…
Metagenome analyses identify human endogenous retrovirus-K113 (HML-2) subtype in glioblastoma. Reply
. 2023 Dec 15;133(24):e176406. doi: 10.1172/JCI176406. Affiliations Expand Affiliations 1 Miller School of Medicine, Department of Neurological Surgery, University of Miami, Coral Gables, Florida, USA. 2 National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA. Item in Clipboard Vaidya Govindarajan et al. J Clin Invest. 2023. Show details Display…
Global Single Cell Sequencing Market Forecast, Report 2024-2031 | 109 Pages Report
(MENAFN– The Express Wire) Global “Single Cell Sequencing Market” report identifies important segments and dynamics, categorizing information to enhance investor comprehension with |109 pages| Medical Care| category report which provides insights into the concentration rate of raw materials in the Single Cell Sequencing Market, the proportion of manufacturing cost structure,…
Car Trim Market Size, Share | Growth, Report [2024-2031]
(MENAFN– The Express Wire) Global “Car Trim Market” report identifies important segments and dynamics, categorizing information to enhance investor comprehension with |119 pages| Automobile and Transportation| category report which provides insights into the concentration rate of raw materials in the Car Trim Market, the proportion of manufacturing cost structure, raw…
Biosensors | Free Full-Text | DNA Probes for Cas12a-Based Assay with Fluorescence Anisotropy Enhanced Due to Anchors and Salts
3.1. Design of Experiments To search optimal structures of ssDNA probes with anchors, we operated with the following assumptions: (1) the anchor should be an easily accessible compound, (2) it should be readily incorporated into the ssDNA probe, (3) it should provide a significant difference in FA before and after…
Preleukemic clonal evolution revealed using single-cell DNA sequencing and computational modelling
Abstract The acquisition of cancer driver mutations can predate diagnosis by decades. However, our understanding of the evolution that occurs in these early stages of cancer remains limited because most studies focus only on sequencing the malignant clone that “wins” the evolutionary race. The representation of driver mutations in the…
Challenges In The Management Of Cutaneous Lymphoma
New York, USA. Symptoms of early-stage cutaneous lymphoma often mimic those of non-malignant cutaneous malignancies such as psoriasis or atopic dermatitis, leading to misdiagnosis and missed opportunities for appropriate treatment.(1) While most patients with cutaneous lymphoma do not progress to advanced-stage, life-threatening disease, for the subgroup of patients who do,…
Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma
Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235–242. Article CAS PubMed Google Scholar Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie…
Vertex Receives CHMP Positive Opinion For The First CRISPR/Cas9 Gene-Edited Therapy CASGEVY
(RTTNews) – Vertex Pharmaceuticals Inc. (VRTX) announced Friday that the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for the conditional approval of CASGEVY (exagamglogene autotemcel [exa-cel]), a CRISPR/Cas9 gene-edited therapy, for the treatment of severe sickle cell disease (SCD) and…
PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis | Cancer Cell International
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi.org/10.3322/caac.21660. Article PubMed Google Scholar Hu G, Chong RA, Yang Q, Wei Y, Blanco…
How to land a scientific position even in a struggling economy
Scientists say they’re finding it increasingly difficult to find a new roles, but there are ways to boost the chances of job applications.Credit: Patrick T. Fallon/Bloomberg via Getty Challenging economic circumstances are affecting scientists’ job searches, with greater competition for limited posts. Nature’s first global survey of postdoctoral researchers revealed…
FDA Approves First Cell-Based Therapies for Treatment of Sickle Cell Disease | Goodwin
On December 8, 2023, the FDA approved the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older—Vertex’s CASGEVY and Bluebird’s LYFGENIA. SCD is a group of inherited blood disorders affecting approximately 100,000 people in the U.S. and inducing a median life…
Senior Bioinformatics Engineer / Software Developer| Science, Engineering & Life Science Recruitment, Jobs & Staffing | SRG
A Bioinformatics Engineer is required to join a small but rapidly expanding company – by joining early in the journey you will gain exposure to the various facets of start-up life and have a unique chance to contribute to the technology and influence company culture. As the company expands this…
Ema recommends approval of genetic scissors therapy for the first time News
For the first time, the European Medicines Agency Ema recommends the conditional approval of a therapy based on the Crispr genetic scissors technology. “Casgevy” is suitable for the treatment of sickle cell disease and beta thalassemia in patients aged twelve and over, said Ema in Amsterdam. Hereditary blood diseases are…
CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs
. 2023 Nov 30:11:1302448. doi: 10.3389/fcell.2023.1302448. eCollection 2023. Affiliations Expand Affiliations 1 Institute for Stem Cell Biology, RWTH Aachen University Medical School, Aachen, Germany. 2 Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany. Item in Clipboard Deepika Puri et al. Front Cell Dev Biol. 2023. Show details Display…
Research and Markets: MONJUVI (tafasitamab-cxix) Drug Insights and Market Forecasts, 2019-2022 and 2023-2032: Focus on 7MM – United States, Germany, France, Italy, Spain, United Kingdom, and Japan
The “MONJUVI Drug Insight and Market Forecast 2032” drug pipelines has been added to ResearchAndMarkets.com‘s offering. This “MONJUVI Drug Insight and Market Forecast 2032” report provides comprehensive insights about MONJUVI for Diffuse Large B-cell lymphoma (DLBCL) in the seven major markets. A detailed picture of the MONJUVI for DLBCL in…
Sickle Cell Disease Gene Therapies Approved by FDA Highlighting Potential of CRISPR/Cas9 Technologies
In a landmark decision last week, the US Food and Drug Administration (FDA) approved two treatments involving cell-based gene therapies. An agency within the US Department of Health and Human Services, the FDA assures the safety, effectiveness, and security of human and veterinary drugs, vaccines, and other biological products for…
Stk3 Mouse shRNA Plasmid (Locus ID 56274) Clinisciences
Product Data Locus ID 56274 Synonyms 0610042I06Rik; mess1; MST; Mst2; Mst3; Ste20 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components Stk3 – Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 56274). 5µg purified plasmid DNA per construct29-mer…
Vertex-CRISPR’s Casgevy Gets Positive EMA Panel Opinion, Approval Decision in Q1 2024
Pictured: European Medicines Agency sign on building/iStock, Lubo Ivanko Following in the footsteps of U.K. and U.S. regulators, a European Medicines Agency committee on Thursday endorsed Vertex Pharmaceuticals and CRISPR Therapeutics’ Casgevy, which is intended for the treatment of sickle cell disease and transfusion‑dependent beta thalassemia in Europe. EMA’s Committee…
First gene editing therapy to treat beta thalassemia and severe sickle cell disease
EMA has recommended approval of the first medicine using CRISPR/Cas9, a novel gene-editing technology. Casgevy (exagamglogene autotemcel) is indicated for the treatment of transfusion‑dependent beta thalassemia and severe sickle cell disease in patients 12 years of age and older for whom haematopoietic stem cell transplantation is appropriate and a suitable donor…
Formononetin | FGFR2 inhibitor | Axon 4067
All All Products Enzymes Receptors Ion Channels Research Areas Oxidoreductases Transferases Lyases Isomerases Ligases Nuclear Receptors Ligand-gated ATP-Sensitive Angiogenesis Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics Immunology Miscellaneous Pain & Inflammation Stem Cell Oxidases MAO Cys-loop, cationic Cis-Trans Isomerase CypA DNA Topoisomerase Synthetases…
How an immune response is driven by one lette
One-letter difference in our DNA determines whether BCG vaccine provides good protection against tuberculosis or not. Researchers at Radboudumc have elucidated how that one letter difference affects the activation and deactivation of the immune system. The discovery, published in Nature Genetics, not only provides more insight into interleukin-driven inflammatory responses,…
Tree size diversity is the major driver of aboveground carbon storage in dryland agroforestry parklands
Albrecht, A. & Kandji, S. T. Carbon sequestration in tropical agroforestry systems. Agric. Ecosyst. Environ. 1–3, 15–27 (2003). Article Google Scholar Nair, P. K. R. Agroforestry systems and environmental quality: Introduction. J. Environ. Qual. 40, 784–790 (2011). Article CAS PubMed Google Scholar Schroth, G. & McNeely, J. A. Biodiversity conservation,…
Approval of gene therapy ‘transformative’ in SCD
New regulatory decisions in the U.S. and the U.K. have made Casgevy (exagamglogene autotemcel) the first gene-editing therapy to be approved for adults and adolescents with sickle cell disease (SCD) who experience painful vaso-occlusive crises (VOCs). With these recent approvals, the therapy from Vertex Pharmaceuticals and CRISPR Therapeutics also became…
Subcutaneous Daratumumab is Safe and Tolerable in Multiple Myeloma
Bone marrow aspirate cytology of multiple myeloma: ©David A Litman – stock.adobe.com Findings from the phase 3 PERSEUS study (NCT03710603) presented at the 2023 ASH Annual Meeting showed that subcutaneous daratumumab (Darzalex) followed by autologous stem cell transplant (ASCT) and daratumumab, bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (D-VRd) consolidation and…
Fate Therapeutics Reports New Employee Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Fate Therapeutics, Inc. SAN DIEGO, Dec. 13, 2023 (GLOBE NEWSWIRE) — Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders, today announced that the Company granted a non-qualified stock…
Charpentier CRISPR patent gets good news from Japan
Life Sciences Intellectual Property Review (LSIPR) tracks the increasing challenges for intellectual property specialists in the rapidly evolving world of life sciences. From gene patents to stem cell research, we provide the very best news and analysis. To continue reading this article and to access 4,500+ articles, our digital magazines and special reports published for…
Evolution of lysine-specific demethylase 1 and REST corepressor gene families and their molecular interaction
The RCOR gene repertoire expanded in the ancestor of jawed vertebrates To understand the duplicative history of the RCOR genes, we reconstructed gene phylogenies with different taxonomic samplings. The first analysis aimed to understand the evolution of RCOR genes in vertebrates (Fig. 2), whereas in the second, our sampling effort included…
Vertex signs $100m CRISPR deal to use sickle cell treatment
Tada Images / Shutterstock.com More on this story Other related Biotech firm agrees licence deal days after its gene editing treatment gets landmark FDA approval | Patents owned by the Broad Institute protect technology sold via Editas Medicines. Life Sciences Intellectual Property Review (LSIPR) tracks the increasing challenges for intellectual property specialists…
New method tags cells with location coordinates for single-cell studies
Brain cells (each represented by a dot), categorized into seven cell types (each a different color), are spatially mapped in a 10 mm square region of the human prefrontal cortex. Credit: Russell AJC et al., Nature 2023, doi:10.1038/s41586-023-06837-4 When a scientist wants to study individual cells at the molecular level…
Programmable Aptasensor for Regulating CRISPR/Cas12a Activity
CRISPR-mediated aptasensors have gained prevalence for detecting non-nucleic acid targets. However, there is an urgent need to develop an easily customizable design to improve the signal-to-noise ratio, enhance universality, and expand the detection range. In this article, we report a CRISPR-mediated programmable aptasensor (CPAS) platform. The platform includes single-stranded DNA…
Texas Workforce Hit Again: Layoffs Continue as Two More Companies Trim Jobs | Ash Jurberg
Layoff Ripple: Two Texas Companies Join the Wave of Job Cuts This Week Each week, I update readers on layoffs in Texas, and unfortunately two more businesses have advised of job cuts. Under the Worker Adjustment and Retraining Notification Act, an employer with more than 100 full-time workers must provide…
Wheat Sequencing Consortium Awarded NSF Grant to Mine Wheat Diversity for Food Security
Newswise — The International Wheat Genome Sequencing Consortium (IWGSC) is starting a two-year project, with funding from the U.S. National Science Foundation (NSF), to mine an untapped genetic resource for wheat improvement by sequencing the genomes of ancient varieties representing the worldwide diversity of bread wheat. In this project –…
Feeder-cell alternatives for large-cell iPSC manufacturing
Cellular immunotherapy—for example, Chimeric Antigen Receptor (CAR)-T cell therapy—has shown great efficacy in treating various hematologic malignancies. CAR-T therapy has undergone notable changes, and several drugs have received regulatory approval for commercial use. Despite these achievements, substantial challenges remain in the widespread use of autologous CAR-T therapy, such as the…
New Embryo-Like Model Simulates Early Human Blood Production
12/13/2023 PITTSBURGH — University of Pittsburgh researchers have developed a new embryo-like model derived from adult cells that replicates key features of early human development, including the generation of blood cells. Described today in Nature, the new heX-Embryoid model provides a unique window into early human development, which has been shrouded in mystery because of…
Clinical Challenges: CAR-T or Bispecifics in Relapsed/Refractory DLBCL
T-cell engaging therapeutic approaches have significantly changed the treatment paradigm for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) in recent years. “They are, by a wide margin, the most impactful new therapies for all B-cell lymphomas, but especially DLBCL, in the last 40 years, if not ever,” said Joshua…
A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception
Identification of novel TAS1R family members We identified homologues of TAS1R genes that are included in public genome/transcriptome databases for diverse taxa of jawed vertebrates (Supplementary Table 1). Except for jawed vertebrates, TAS1R genes were not identified in any Deuterostomia reference genomes (lampreys, hagfishes, tunicates, lancelets, sea urchins, starfish, hemichordate,…
Loading R Packages In RStudio: A Step-By-Step Approach
Article Summary Box Preparing RStudio for package management is pivotal, involving setting up workspace directories and ensuring R version compatibility for optimal package functionality. In Understanding Package Libraries, the intricacies of library paths and package storage locations reveal strategies for streamlined package accessibility and organization. Advanced Techniques for Package Loading…
Different results Pytorch vs Libtorch – C++
Hello!I recently succeded to save a model from pytorch and load in libtorch.I am using the mono_640x192 pretrained model.I am trying to calculate the disparity map for a single picture, but I get different results in python compared to c++.I tried and followed to code in python to process the…
DNA Sequencing Technologies Market Report | Global Forecast From 2024 -2031
(MENAFN– The Express Wire) Global 92 Pages Updated Report of “DNA Sequencing Technologies Market” report also encompasses Size and Share analysis and trend analysis of |92 pages|Medical Care| category report shedding light on key opportunities within the rapidly growing international DNA Sequencing Technologies industry segments. DNA Sequencing Technologies Market Report…
A Breakthrough Study at University at Buffalo
Researchers at the University at Buffalo (UB) have made significant strides in understanding and potentially treating a rare kidney disease known as infantile cystinosis. This disease is characterized by a defect in the genesis of a crucial component of the kidney, which dramatically shortens the patient’s lifespan. However, through the…
Local sickle cell patient reacts to new treatment options
TAMPA, Fla. — The FDA recently approved two different gene therapies to treat sickle cell disease, and many doctors and patients living with the painful disease say this is a long time coming. What You Need To Know The two newly approved gene therapies each use a different method According to the FDA, in…