Tag: TCC

Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation

Ethics and animal welfare statement All infectious work with RESTV, including sample inactivation, was performed in the Containment Level 4 laboratory (CL4) in accordance with the policies and protocols outlined by the Canadian Science Centre for Human and Animal Health Institutional Biosafety Committee. All animal work was performed in strict…

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Bioconductor – DESeq2 (development version)

DOI: 10.18129/B9.bioc.DESeq2   This is the development version of DESeq2; for the stable release version, see DESeq2. Differential gene expression analysis based on the negative binomial distribution Bioconductor version: Development (3.19) Estimate variance-mean dependence in count data from high-throughput sequencing assays and test for differential expression based on a model…

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Solved Using the provided SNP IDs and primer sequence

Using the provided SNP IDs and primer sequence utilize dbSNP to find the appropriate sequences to help you determine the size of your expected PCR product. Hint: sometime you can use the free PCR primer programs to help you search sequences with your already designed primers should include: the gene…

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Final Multivariate Analysis from the Phase 3 MAGNITUDE Study Shows Trend Toward Improvement in Overall Survival in Patients with mCRPC with BRCA Alterations Treated with Niraparib and Abiraterone Acetate Plus Prednisone

Niraparib and abiraterone acetate plus prednisone combination therapy also showed clinically relevant improvement versus standard of care in time to symptomatic progression and time to cytotoxic chemotherapy MADRID, Oct. 22, 2023 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the final analysis (FA) of…

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Survival Benefit Shown With Niraparib Plus Abiraterone in BRCA+ mCRPC

Kim Nguyen N. Chi, MD, FRCPC Increased overall survival (OS) was demonstrated with niraparib (Zejula) plus abiraterone acetate (Zytiga) and prednisone (AAP) vs AAP alone in patients with BRCA1/2-mutated (BRCA+) metastatic castration-resistant prostate cancer (mCRPC), according to the phase 3 MAGNITUDE trials (NCT03748641) updated data presented at the ESMO Congress…

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Final Multivariate Analysis from the Phase 3 MAGNITUDE

Niraparib and abiraterone acetate plus prednisone combination therapy also showed clinically relevant improvement versus standard of care in time to symptomatic progression and time to cytotoxic chemotherapy1 BEERSE, BELGIUM, Oct. 22, 2023 (GLOBE NEWSWIRE) — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the final analysis…

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ncRNA | Free Full-Text | Long Non-Coding RNA TUG1 Gene Polymorphism and TUG1 Expression Level as Molecular Biomarkers of Systemic Lupus Erythematosus and Lupus Nephritis

1. Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide variety of manifestations ranging from mild cutaneous to organ failure as lupus nephritis (LN) and cardiopulmonary complications [1]. SLE is mainly present among young women, with a greater incidence in certain ethnic groups, such as Asian,…

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Temas para TCC Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples.

Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. AUTOR(ES) Langendijk, P S RESUMO Three 16S rRNA hybridization probes were developed and tested for genus-specific detection of Bifidobacterium species in the human fecal flora. Variable regions V2, V4, and V8…

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Temas para TCC Resistance to Linezolid: Characterization of Mutations in rRNA and Comparison of Their Occurrences in Vancomycin-Resistant Enterococci

Resistance to Linezolid: Characterization of Mutations in rRNA and Comparison of Their Occurrences in Vancomycin-Resistant Enterococci AUTOR(ES) Prystowsky, Jason FONTE American Society for Microbiology RESUMO To assess the potential for emergence of resistance during the use of linezolid, we tested 10 clinical isolates of vancomycin-resistant enterococci (VRE) (four Enterococcus faecalis,…

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Temas para TCC tRNA genes are found between 16S and 23S rRNA genes in Bacillus subtilis.

tRNA genes are found between 16S and 23S rRNA genes in Bacillus subtilis. AUTOR(ES) Loughney, K RESUMO There are at least nine, and probably ten, ribosomal RNA gene sets in the genome of Bacillus subtilis. Each gene set contains sequences complementary to 16S, 23S and 5S rRNAs. We have determined…

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Temas para TCC Characterization of universal small-subunit rRNA hybridization probes for quantitative molecular microbial ecology studies.

Characterization of universal small-subunit rRNA hybridization probes for quantitative molecular microbial ecology studies. AUTOR(ES) Zheng, D RESUMO Universal oligonucleotide hybridization probes targeting the small-subunit rRNA are commonly used to quantify total microbial representation in environmental samples. Universal probes also serve to normalize results obtained with probes targeting specific phylogenetic groups…

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Temas para TCC RNA Polymerase III Transcription Complexes on Chromosomal 5S rRNA Genes In Vivo: TFIIIB Occupancy and Promoter Opening

RNA Polymerase III Transcription Complexes on Chromosomal 5S rRNA Genes In Vivo: TFIIIB Occupancy and Promoter Opening AUTOR(ES) Costanzo, G. FONTE American Society for Microbiology RESUMO Quantitative analysis of multiple-hit potassium permanganate (KMnO4) footprinting has been carried out in vivo on Saccharomyces cerevisiae 5S rRNA genes. The results fix the…

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Temas para TCC Phylogenetic analysis of the coryneform bacteria by 5S rRNA sequences.

Phylogenetic analysis of the coryneform bacteria by 5S rRNA sequences. AUTOR(ES) Park, Y H RESUMO Nucleotide sequences of 5S rRNAs from 11 coryneform bacteria were determined. These were the type strains of Corynebacterium glutamicum, Corynebacterium xerosis, Brevibacterium linens, Arthrobacter globiformis, Cellulomonas biazotea, Aureobacterium testaceum, Curtobacterium citreum, Pimelobacter simplex, and Caseobacter…

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Step-by-Step Guide to Setup Pytorch for Your GPU on Windows 10/11

In this competitive world of technology, Machine Learning and Artificial Intelligence technologies have emerged as a breakthrough for developing advanced AI applications like image recognition, natural language processing, speech translation, and more. However, developing such AI-powered applications would require massive amounts of computational power far beyond the capabilities of CPUs…

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IJMS | Free Full-Text | The Impact of the CYP2D6 and CYP1A2 Gene Polymorphisms on Response to Duloxetine in Patients with Major Depression

Received: 16 July 2023 / Revised: 25 August 2023 / Accepted: 29 August 2023 / Published: 30 August 2023 Round 1 Reviewer 1 Report The manuscript “The impact of the CYP2D6 and CYP1A2 Gene Polymorphisms on Response to Duloxetine in Patients with Major Depression” addresses how some SNPs of these…

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Torch.cuda.is_available() is False – CUDA:12.2 – rtx 4070

TTTest July 28, 2023, 12:02pm 1 Machine learning newbie here, stuck on the first step of learning PyTorch of installing CUDA. I’ve been trying to get CUDA working on my system for the past day to no avail. I’ve created multiple environments then tried installing pytorch using the below config…

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python – PyTorch torch.cuda.is_available() returns False for Windows

First run nvidia-smi. This will give you your driver and what CUDA version you can support up to. e.g., for me, the top box says this: +—————————————————————————–+ | NVIDIA-SMI 527.41 Driver Version: 527.41 CUDA Version: 12.0 | |——————————-+———————-+———————-+ | GPU Name TCC/WDDM | Bus-Id Disp.A | Volatile Uncorr. ECC |…

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A geopositioned and evidence-graded pan-species compendium of Mayaro virus occurrence

Anderson, C. R., Downs, W. G., Wattley, G. H., Ahin, N. W. & Reese, A. A. Mayaro virus: a new human disease agent. II. Isolation from blood of patients in Trinidad, B.W.I. Am. J. Trop. Med. Hyg. 6, 1012–1016, doi.org/10.4269/ajtmh.1957.6.1012 (1957). Article  CAS  PubMed  Google Scholar  Causey, O. R. &…

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Recent FDA Actions: June 2023

FDA Approves Enfortumab Vedotin Plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma The FDA has granted accelerated approval to enfortumab vedotin-ejfv (Padcev) plus pembrolizumab (Keytruda) for patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin-containing chemotherapy.1 The regulatory decision was supported by data from the…

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The draft genome sequence of the Japanese rhinoceros beetle Trypoxylus dichotomus septentrionalis towards an understanding of horn formation

Hunt, T. et al. A comprehensive phylogeny of beetles reveals the evolutionary origins of a superradiation. Science 318, 1913–1916 (2007). Article  ADS  CAS  PubMed  Google Scholar  Crowson, R. A. The phylogeny of coleoptera. Annu. Rev. Entomol. 5, 111–134 (1960). Article  Google Scholar  Darwin, C. The Descent of Man, and Selection…

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Deletion of endothelial leptin receptors in mice promotes diet-induced obesity

Experimental animals The generation of mice with tamoxifen-inducible, Tie2.Cre-ERT2-mediated deletion of LepR in endothelial cells was described previously12,17. For Cre recombinase activation, mice (6 weeks-of-age) were fed tamoxifen citrate-containing rodent chow (Envigo; TD.130860) for 6 weeks49. Genomic DNA from the brain, lung, small intestine, subcutaneous adipose tissue (SCAT) and visceral adipose tissue…

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Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

Recombinant protein expression and purification NanoLuc is the tradename of an engineered deep-sea shrimp luciferase variant developed by Promega Corporation36. Genes encoding fusion proteins were inserted into pET-21d(+) vectors between NcoI and XhoI sites. IDO-Gal3 genetic and protein sequences are provided in Supplementary Information. Plasmids confer ampicillin resistance and were…

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Trends and prospects in mitochondrial genome editing

Mitochondria, double membrane-bound organelles referred to as the “powerhouses of the cell”, play an indispensable role in eukaryotic cells, as they are associated with metabolism1,2 and orchestrate a variety of other cellular functions, such as apoptosis, cell pluripotency, autophagy, calcium homeostasis, and innate immunity3,4,5,6,7,8,9. The mitochondrial genome is independent and…

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python – Pytorch can’t find gpu

I begin to learn ML on my windows11 machine. But torch can’t find my gpu. In [2]: device = torch.device(“cuda:0” if torch.cuda.is_available() else “cpu”) In [3]: device Out[3]: device(type=”cpu”) This is my nvidia-smi outputs +—————————————————————————————+ | NVIDIA-SMI 531.68 Driver Version: 531.68 CUDA Version: 12.1 | |—————————————–+———————-+———————-+ | GPU Name TCC/WDDM…

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Twist Bioscience and Aster Insights Partner on Launch of Next Generation Oncology Panel for Cancer Research

Comprehensive capture panel to enable enhanced bioinformatics-based oncology research SOUTH SAN FRANCISCO, Calif. & TAMPA, Fla.–(BUSINESS WIRE)– Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, and Aster Insights, a bioinformatics company with the most advanced, direct-patient,…

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PAI-1 4G/5G polymorphism in patients with DM & hypertension

Introduction Diabetes mellitus (DM) is a group of metabolic syndromes characterized by disorders of glucose metabolism, including type 1 DM, type 2 DM, gestational DM, and specific types of DM due to other causes. DM is closely associated with abnormal cardiac electrophysiological signal conduction and arrhythmias, whereby it triggers sudden…

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machine learning – pytorch cannot built running processes on Tesla V100-PCIE-32GB (type: (7, 0))

On remote server, PyTorch can access the GPU that can place variables and models on GPUs, but the GPU shows no running processes found on the GPU. Thu Apr 20 09:21:59 2023 +—————————————————————————–+ | NVIDIA-SMI 511.65 Driver Version: 452.39 CUDA Version: 11.0 | |——————————-+———————-+———————-+ | GPU Name TCC/WDDM | Bus-Id…

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M2GEN Rebrands to Aster Insights

Leading oncology bioinformatics company unveils new name, logo, and website as part of transformative rebranding initiative TAMPA, Fla., April 14, 2023 /PRNewswire/ — M2GEN, an oncology bioinformatics company with the most advanced lifetime-consented clinicogenomic data to accelerate medical product discovery, today announced it is rebranding, changing the company’s name to Aster…

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Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens

Search for creTA elements associating with I-F CRISPR-Cas Previously identified creTA genes all surround the cas6 gene of a type I or III CRISPR-Cas19. Yet, within the I-F CRISPR-Cas loci of Acinetobacter species, we did not find any creTA-like elements by searching the sequences surrounding csy4 (a subtype-specific cas6 gene)….

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Comprehensive benchmark and architectural analysis of deep learning models for nanopore sequencing basecalling | Genome Biology

Benchmark setup We first developed a basecalling benchmarking framework enabling new and existing basecalling algorithms to be easily compared. Moreover, our benchmark facilitates the study of individual components of basecallers, as different combinations of basecaller components can readily be evaluated. The framework is divided into two main components: (i) standardized…

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Urothelial Carcinoma Pipeline Assets and Comparative Analysis of Clinical and Non-Clinical Stage Products

PRESS RELEASE Published March 13, 2023 DelveInsight’s, “Urothelial Carcinoma Pipeline Insight, 2023,” report provides comprehensive insights about 40+ companies and 50+ pipeline drugs in the Urothelial Carcinoma pipeline landscape. It covers the Urothelial Carcinoma pipeline drug profiles, including Urothelial Carcinoma clinical trials and nonclinical stage products. It also covers the…

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Bioconductor – metaseqR2

DOI: 10.18129/B9.bioc.metaseqR2     An R package for the analysis and result reporting of RNA-Seq data by combining multiple statistical algorithms Bioconductor version: Release (3.11) Provides an interface to several normalization and statistical testing packages for RNA-Seq gene expression data. Additionally, it creates several diagnostic plots, performs meta-analysis by combinining…

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CUDA Toolkit v12.0 failed to compile every sample with .cu files on Windows 10 and Visual Studio 2022 – CUDA Setup and Installation

Build started…1>—— Build started: Project: bandwidthTest, Configuration: Debug x64 ——1>Compiling CUDA source file bandwidthTest.cu…1>1>D:\CUDA\v12.0\cuda-samples-12.0\Samples\1_Utilities\bandwidthTest>“D:\CUDA\v12.0\bin\nvcc.exe” -gencode=arch=compute_50,code=”sm_50,compute_50″ -gencode=arch=compute_52,code=”sm_52,compute_52″ -gencode=arch=compute_60,code=”sm_60,compute_60″ -gencode=arch=compute_61,code=”sm_61,compute_61″ -gencode=arch=compute_70,code=”sm_70,compute_70″ -gencode=arch=compute_75,code=”sm_75,compute_75″ -gencode=arch=compute_80,code=”sm_80,compute_80″ -gencode=arch=compute_86,code=”sm_86,compute_86″ -gencode=arch=compute_90,code=”sm_90,compute_90″ –use-local-env -ccbin “D:\VS\2022\Professional\VC\Tools\MSVC\14.34.31933\bin\HostX64\x64” -x cu -I./ -I…/…/…/Common -I./ -ID:\CUDA\v12.0/include -I…/…/…/Common -I”D:\git\vcpkg\installed\x64-windows\include” -ID:\CUDA\v12.0\include -G –keep-dir x64\Debug -maxrregcount=0 –machine 64 –compile -cudart static -Xcompiler “/wd 4819” –threads 0 -g…

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Molecular characterization and antimicrobial susceptibility profiles of Thai Mycoplasma synoviae isolates

Isolation of M. synoviae field isolates M. synoviae field isolates were obtained from approximately ninety flocks of registered commercial chicken farms, including breeder flocks, broiler flocks, and layer flocks in Thailand in 2020. Chickens were individually swabbed at the articular joint or the respiratory tract; choanal cleft, tra,chea and airsac;…

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Bioconductor – DESeq2

DOI: 10.18129/B9.bioc.DESeq2     This package is for version 3.10 of Bioconductor; for the stable, up-to-date release version, see DESeq2. Differential gene expression analysis based on the negative binomial distribution Bioconductor version: 3.10 Estimate variance-mean dependence in count data from high-throughput sequencing assays and test for differential expression based on…

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