Tag: TFAM
Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing
Oosthuizen T, Howes LM (2022) The development of forensic DNA analysis: new debates on the issue of fundamental human rights. Forensic Sci Int Genet 56:102606 Article CAS PubMed Google Scholar Nwawuba Stanley U et al (2020) Forensic DNA profiling: autosomal short tandem repeat as a prominent marker in crime investigation….
Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity
Jerby-Arnon, L.; Shah, P.; Cuoco, M. S.; Rodman, C.; Su, M. J.; Melms, J. C.; Leeson, R.; Kanodia, A.; Mei, S. L.; Lin, J. R. et al. A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade. Cell 2018, 175, 984–997.e24. Article CAS Google Scholar Li, X….
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction
Study design The overall goal of this study was to explore the molecular mechanisms of remdesivir-related cardiotoxicity in anti-COVID-19 therapy. We first performed the GPCR screening using major anti-COVID-19 drugs as ligands (n = 3 per GPCR). We validated the results of GPCR screening by concentration-response analysis and determined the EC50 and…
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature that involves movable joints. The set of features that take place during the development of the disease lead to consider OA as a severe disease of the whole joint as an organ.1–3 The aetiology of knee…
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Review doi: 10.1038/s12276-023-00965-7. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. jhk@catholic.ac.kr. 2 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. 3 Laboratory of Obesity and Aging Research,…
Key Amino Acid Residues of Mitochondrial Transcription Factor A Synergize with Abasic (AP) Site Dynamics To Facilitate AP-Lyase Reactions
Human mitochondrial DNA (mtDNA) encodes 37 essential genes and plays a critical role in mitochondrial and cellular functions. mtDNA is susceptible to damage by endogenous and exogenous chemicals. Damaged mtDNA molecules are counteracted by the redundancy, repair, and degradation of mtDNA. In response to difficult-to-repair or excessive amounts of DNA…
Almost no peak output after peakcalling of mtDNA with MACS2
Almost no peak output after peakcalling of mtDNA with MACS2 0 I am new to the CHIP-seq analysis. I am basically trying to call peaks using MACS 2 with the proccessed data of mitochondrial DNA only in bedgraph format given in the accession number GSE48176 under the link www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48176. I…
[E::idx_find_and_load] warning in htseq-count
[E::idx_find_and_load] warning in htseq-count 0 I am running the htseq-count but get the [E::idx_find_and_load] warning. The bam files were sorted with name but without index. It is not required for index when running htseq-count, correct? *CODE: htseq-count -f bam \ -s no \ -t exon \ -m union \ -i…
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice | Cell Communication and Signaling
Malhi GS, Mann JJ. Depression. Lancet. 2018;392:2299–312. Article Google Scholar Wang B, Zhang H, Cao X. Research progress of non-monoamine antidepressants. Stress Brain. 2021;1:128–44. Article Google Scholar Coccaro EF. New hope for patients with major depressive disorder? N Engl J Med. 2019;381:980–1. Article Google Scholar Cai N, Chang S, Li…
Origins and diversification of animal innate immune responses against viral infections
Harvey, E. & Holmes, E. C. Diversity and evolution of the animal virome. Nat. Rev. Microbiol. 20, 321–334 (2022). Article CAS Google Scholar Flajnik, M. F. & du Pasquier, L. Evolution of innate and adaptive immunity: can we draw a line? Trends Immunol. 25, 640–644 (2004). Article CAS Google Scholar …
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis | Journal of Neuroinflammation
Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8. doi.org/10.1097/00001199-200609000-00001. Article PubMed Google Scholar Cao HQ, Dong ED. An update on spinal cord injury research. Neurosci Bull. 2013;29:94–102. doi.org/10.1007/s12264-012-1277-8. Article PubMed Google Scholar O’Donnell MJ, Xavier D,…
As of July 2015, the VCFtools project has been moved to github! Please visit the new website here: vcftools.github.io/man_0112a.html
NAME SYNOPSIS DESCRIPTION EXAMPLES BASIC OPTIONS SITE FILTERING OPTIONS INDIVIDUAL FILTERING OPTIONS GENOTYPE FILTERING OPTIONS OUTPUT OPTIONS COMPARISON OPTIONS AUTHOR NAME VCFtools v0.1.12a − Utilities for the variant call format (VCF) and binary variant call format (BCF) SYNOPSIS vcftools [ –vcf FILE | –gzvcf FILE | –bcf FILE]…
Probing the Mammalian Mitochondrial Nucleoid
dc.contributor.author Rajala, Nina dc.date.accessioned 2015-04-29T04:47:49Z dc.date.available 2015-04-29T04:47:49Z dc.date.issued 2015 dc.identifier.isbn 978-951-44-9794-0 – dc.identifier.uri trepo.tuni.fi/handle/10024/96996 dc.description.abstract Mitokondrioiden tärkein tehtävä on energian tuottaminen. Mitokondriot ovat solujen hengityskeskuksia, joissa 90 % tarvitsemastamme energiasta tuotetaan oksidatiivisen fosforylaation kautta elektroninsiirtoketjua apuna käyttäen. Kun mitokondriot eivät toimi kunnolla, tuloksena voi olla energiakriisi, erityisesti lihaksissa, aivoissa ja…
Dissertations.se: MITOCHONDRIAL DNA REPLICATION
Showing result 1 – 5 of 29 swedish dissertations containing the words Mitochondrial DNA replication. Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA;…
Dissertations.se: INITIATION OF DNA REPLICATION
Showing result 1 – 5 of 43 swedish dissertations containing the words initiation of DNA replication. Author : Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication; Abstract : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and…
The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction,…
Dissertations.se: MITOCHONDRIAL CARDIOMYOPATHY
Showing result 1 – 5 of 9 swedish dissertations containing the words mitochondrial cardiomyopathy. Author : Gittan Kollberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase…
Korean red ginseng reduces ageing-related issues in postmenopausal women
Although no exact mechanism has been identified for the ageing process in women after menopause, several epidemiological studies have shown that there are many diseases related to ageing in postmenopausal women, such as type 2 diabetes and cardiovascular disease, both of which are closely linked to oxidative stress and chronic…
mitochondrial dna damage triggers an ifn mediated immune response
2.6 Mitochondrial Damage-Induced Mitochondrial DNA Release is Central to Chronic Kidney Disease-Induced Type-I-Interferon Response in Vascular Smooth Muscle Cells DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS-STING pathway. This is thought to be mediated by the presence 75 of leaked mitochondrial DNA…
