Tag: TFAM

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic…

Continue Reading Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

New Mechanism of mtDNA Release: Groundbreaking Discovery

A Groundbreaking Discovery: New Mechanism of mtDNA Release Scientists have recently discovered a breakthrough pathway for the release of mitochondrial DNA (mtDNA) during Herpes Simplex Virus-1 (HSV-1) infection or mitochondrial transcription factor A (TFAM) deficiency. This novel mechanism, distinct from previously established ones, does not involve BAK, BAX, or VDACs,…

Continue Reading New Mechanism of mtDNA Release: Groundbreaking Discovery

Sperm Cell Powerhouses Contain Almost No DNA

January 1, 2024 2 min read Scientists discover why fathers usually don’t pass on their mitochondria’s genome By Sneha Khedkar Credit: Kateryna Kon/Science Source Almost every human cell is powered by mitochondria, bean-shaped organelles that use oxygen to synthesize usable energy. These structures evolved billions of years ago from free-swimming…

Continue Reading Sperm Cell Powerhouses Contain Almost No DNA

The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases

Annesley SJ, Fisher PR (2019) Mitochondria in health and disease. Cells 8(7). doi.org/10.3390/cells8070680 Cannino G, Ferruggia E, Luparello C, Rinaldi AM (2009) Cadmium and mitochondria. Mitochondrion 9(6):377–384. doi.org/10.1016/j.mito.2009.08.009 Article  CAS  PubMed  Google Scholar  Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial control of genomic…

Continue Reading The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases

The effect of Coenzyme Q10 on mitochondrial biogenesis in mouse ovarian follicles during in vitro culture

doi: 10.1017/S0967199423000461. Online ahead of print. Affiliations Expand Affiliations 1 School of Biology, Damghan University, Damghan, Iran. 2 Institute of Biological Sciences, Damghan University, Damghan, Iran. Item in Clipboard Roya Harsini et al. Zygote. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1017/S0967199423000461. Online ahead of print. Affiliations 1…

Continue Reading The effect of Coenzyme Q10 on mitochondrial biogenesis in mouse ovarian follicles during in vitro culture

Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

Chronic Kidney Disease in the United States, 2021. www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html. Saran, R. et al. US renal data system 2019 annual data report: Epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 75, A6–A7 (2020). Article  PubMed  Google Scholar  Matsushita, K. et al. Epidemiology and risk of cardiovascular disease…

Continue Reading Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

A novel mouse model of mitochondrial disease exhibits juvenile-onset severe neurological impairment due to parvalbumin cell mitochondrial dysfunction

Conditional Tfam knockout in PV-expressing cells causes juvenile-onset of motor deficits and neurological impairment We mechanistically explored the hypothesis of whether selective PV+ cell mitochondrial dysfunction would be sufficient to induce a neurological phenotype reminiscent of human mitochondrial disease14 by creating a suitable in vivo mitochondrial disease model based on…

Continue Reading A novel mouse model of mitochondrial disease exhibits juvenile-onset severe neurological impairment due to parvalbumin cell mitochondrial dysfunction

Mechanism of sperm mtDNA elimination

Mechanism of sperm mtDNA elimination Premium accounts now available! Sign up and create a premium account. Read more Life Science Network Close Life Science Network This site uses cookies. Some cookies are essential to make the site work and others help us to improve our services.View Cookie settings or read…

Continue Reading Mechanism of sperm mtDNA elimination

Stressed mitochondria sound the alarm.

Immunology and Cell Biology (2015), 1–2 & 2015 Australasian Society for Immunology Inc. All rights reserved 0818-9641/15 www.nature.com/icb NEWS AND COMMENTARY mtDNA stress triggers interferon production Stressed mitochondria sound the alarm Michael J White and Benjamin T Kile Immunology and Cell Biology advance online publication, 10 March 2015; doi:10.1038/icb.2015.31 M…

Continue Reading Stressed mitochondria sound the alarm.

The activation of cGAS-STING in acute kidney injury

Introduction AKI, which is characterised by necroinflammation due to damage and necrosis of the kidney’s intrinsic cells,1 is a common clinical syndrome, occurring in 10–15% of hospitalized patients, whereas in the ICU this percentage is as high as 50%.2 The development of AKI is involved in the production of reactive…

Continue Reading The activation of cGAS-STING in acute kidney injury

The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles

Bosch E, De Vos M, Humaidan P. The future of cryopreservation in assisted reproductive technologies. Front Endocrinol (Lausanne). 2020;11:1–15. Article  Google Scholar  De Geyter C, Calhaz-Jorge C, Kupka MS, Wyns C, Mocanu E, Motrenko T, et al. ART in Europe, 2015: results generated from European registries by ESHRE†. Hum Reprod…

Continue Reading The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles

The Role of Mitochondrial DNA in Human Reproduction

This article explores new research that confirms the scientific understanding that mitochondrial DNA (mtDNA) is exclusively inherited from the mother. The study, published in the journal Nature Genetics, was a collaboration among Oregon Health & Science University and other institutions. Previously, it was believed that paternal mtDNA was eliminated after…

Continue Reading The Role of Mitochondrial DNA in Human Reproduction

Study reveals mature sperm lack intact mitochondrial DNA

New research sheds light on the fundamental scientific premise that mitochondrial DNA — the particular genetic code stored in the organelle that serves as the powerplant for every cell in the body — is exclusively passed down by the mother. The study, a collaboration among Oregon Health & Science University…

Continue Reading Study reveals mature sperm lack intact mitochondrial DNA

New Research Uncovers the Exclusive Maternal Inheritance of Mitochondrial DNA: Implications for Human Fertility and Germ Cell Therapy

New Research Confirms that Mitochondrial DNA is Exclusively Passed Down by the Mother Scientists from Oregon Health & Science University and other institutions have made a breakthrough discovery regarding mitochondrial DNA (mtDNA) inheritance. The study, published in the journal Nature Genetics, sheds light on the longstanding scientific principle that only…

Continue Reading New Research Uncovers the Exclusive Maternal Inheritance of Mitochondrial DNA: Implications for Human Fertility and Germ Cell Therapy

New Research Reveals Insights into Maternal Inheritance of Mitochondrial DNA

A recently published study in the journal Nature Genetics sheds light on the long-standing scientific principle that mitochondrial DNA (mtDNA) is exclusively passed down by the mother. The collaborative research, led by Oregon Health & Science University, provides new insights into the mechanisms behind this phenomenon. Mitochondrial DNA, found in…

Continue Reading New Research Reveals Insights into Maternal Inheritance of Mitochondrial DNA

Mature sperm lack intact mitochondrial DNA, study finds

Shoukhrat Mitalipov, Ph.D., director of the Center for Embryonic Cell and Gene Therapy at OHSU, and professor of obstetrics and gynecology, molecular and cellular biosciences, OHSU School of Medicine, OHSU Oregon National Primate Research Center. (OHSU/Christine Torres Hicks) New research provides insight about the bedrock scientific principle that mitochondrial DNA…

Continue Reading Mature sperm lack intact mitochondrial DNA, study finds

Molecular basis for maternal inheritance of human mitochondrial DNA

Ankel-Simons, F. & Cummins, J. M. Misconceptions about mitochondria and mammalian fertilization: implications for theories on human evolution. Proc. Natl Acad. Sci. USA 93, 13859–13863 (1996). Article  CAS  PubMed  PubMed Central  Google Scholar  Wallace, D. C. Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine….

Continue Reading Molecular basis for maternal inheritance of human mitochondrial DNA

New data on the safety of ‘three genetic parents’ therapy

2023-09-18 17:00:05 An investigation that is published in the magazine ‘Nature Genetics‘ provides information on the fundamental scientific principle that mitochondrial DNA (the distinctive genetic code embedded in the organelle that serves as the powerhouse of each cell in the body) is transmitted exclusively by the mother. The information is…

Continue Reading New data on the safety of ‘three genetic parents’ therapy

Research Reveals Mature Sperm Lacks Intact Mitochondrial DNA

New research provides insight about the bedrock scientific principle that mitochondrial DNA — the distinct genetic code embedded in the organelle that serves as the powerplant of every cell in the body — is exclusively passed down by the mother. The study, a collaboration among Oregon Health & Science University…

Continue Reading Research Reveals Mature Sperm Lacks Intact Mitochondrial DNA

DNA | Free Full-Text | TFAM in mtDNA Homeostasis: Open Questions

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of…

Continue Reading DNA | Free Full-Text | TFAM in mtDNA Homeostasis: Open Questions

Optimized bisulfite sequencing analysis reveals the lack of 5-methylcytosine in mammalian mitochondrial DNA

doi: 10.1186/s12864-023-09541-9. Affiliations Expand Affiliations 1 State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. shaozhenyu2017@sibcb.ac.cn. 2 Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical…

Continue Reading Optimized bisulfite sequencing analysis reveals the lack of 5-methylcytosine in mammalian mitochondrial DNA

Plausible Role of Mitochondrial DNA Copy Number in Neurodegeneration-a Need for Therapeutic Approach in Parkinson’s Disease (PD)

Review doi: 10.1007/s12035-023-03500-x. Online ahead of print. Affiliations Expand Affiliations 1 Centre for Neuroscience, Department of Biotechnology, Karpagam Academy of Higher Education (Deemed to Be University), Coimbatore, 641021, India. 2 Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India. 3 Department of Biomedical Sciences, School of…

Continue Reading Plausible Role of Mitochondrial DNA Copy Number in Neurodegeneration-a Need for Therapeutic Approach in Parkinson’s Disease (PD)

Ray of hope for mitochondrial diseases: protein’s surprising second role

A protein that packs massive DNA strands into tiny cells also moonlights as a cleaner of damaged genetic material. This discovery could help detect mitochondrial diseases, which can cause brain damage and organ failure.  TFAM acts as molecular scissors to cleave AP sites in mitochondria. (Linlin Zhao/UCR) DNA carries all…

Continue Reading Ray of hope for mitochondrial diseases: protein’s surprising second role

Moringa oleifera leaves extract ameliorates cardiotoxicity

Cyntia Gracesella Patintingan,1 Melva Louisa,2 Vetnizah Juniantito,3 Wawaimuli Arozal,2 Silmi Hanifah,1 Septelia Inawati Wanandi,4 Rajarajan Thandavarayan5 1Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 3Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, Agriculture Institute of Bogor,…

Continue Reading Moringa oleifera leaves extract ameliorates cardiotoxicity

IJMS | Free Full-Text | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity

Each cell contains many mitochondria, and each mitochondria contains several copies of mtDNA [11]. mtDNA is located in the mitochondrial matrix in close proximity to the electron transport chain, the major source of reactive oxygen species. Therefore, mtDNA is particularly susceptible to oxidation leading to mutations and the development of…

Continue Reading IJMS | Free Full-Text | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity

Unlocking the Anti-Aging Potential of Protein in Human Cells

Summary: Researchers have uncovered an anti-aging function in a protein, ATSF-1, found deep within human cells. This protein controls a delicate balance between the creation and repair of mitochondria, which produce energy and contribute to cell aging. By enhancing ATSF-1 function, cellular health was improved in a study using C….

Continue Reading Unlocking the Anti-Aging Potential of Protein in Human Cells

Extra header column stopping EMMAX (C), but not seen in input files

I’m using a C implementation of EMMAX for GWAS and am getting an error that I can’t get to the bottom of because I don’t know enough about C. I hope there’s a C expert who can take a quick look at this and let me know which of my…

Continue Reading Extra header column stopping EMMAX (C), but not seen in input files

Mitoepigenetics and gliomas: epigenetic alterations to mitochondrial DNA and nuclear DNA alter mtDNA expression and contribute to glioma pathogenicity

Review . 2023 May 30;14:1154753. doi: 10.3389/fneur.2023.1154753. eCollection 2023. Affiliations Expand Affiliations 1 Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, United States. 2 Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, United States. Item in Clipboard Review Clare I Grady et al….

Continue Reading Mitoepigenetics and gliomas: epigenetic alterations to mitochondrial DNA and nuclear DNA alter mtDNA expression and contribute to glioma pathogenicity

I-Mitochondrial DNA (mtDNA) Indlela Yokuphindaphinda, Izinto

Ikhaya » Microbiology » Ufuzo Advertisements HSP umgqugquzeli we-strand esindayo I-LSP ukukhanya strand umgqugquzeli MGME1 i-mitochondrial genome maintenance exonuclease 1 mtSSB I-mitochondrial enemicu eyodwa ye-DNA-binding protein NCR isifunda esingabhali ikhodi I-TAS ukulandelana okuhlobene nokuqedwa I-Mitochondrial DNA (mtDNA) iyi-molecule eyi-16.6 kilobase enemicu ephindwe kabili. Umucu owodwa we-DNA ye-mitochondrial inothe ngama-guanines, okuvumela…

Continue Reading I-Mitochondrial DNA (mtDNA) Indlela Yokuphindaphinda, Izinto

Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing

Oosthuizen T, Howes LM (2022) The development of forensic DNA analysis: new debates on the issue of fundamental human rights. Forensic Sci Int Genet 56:102606 Article  CAS  PubMed  Google Scholar  Nwawuba Stanley U et al (2020) Forensic DNA profiling: autosomal short tandem repeat as a prominent marker in crime investigation….

Continue Reading Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing

Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity

Jerby-Arnon, L.; Shah, P.; Cuoco, M. S.; Rodman, C.; Su, M. J.; Melms, J. C.; Leeson, R.; Kanodia, A.; Mei, S. L.; Lin, J. R. et al. A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade. Cell 2018, 175, 984–997.e24. Article  CAS  Google Scholar  Li, X….

Continue Reading Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

Study design The overall goal of this study was to explore the molecular mechanisms of remdesivir-related cardiotoxicity in anti-COVID-19 therapy. We first performed the GPCR screening using major anti-COVID-19 drugs as ligands (n = 3 per GPCR). We validated the results of GPCR screening by concentration-response analysis and determined the EC50 and…

Continue Reading Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis

Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature that involves movable joints. The set of features that take place during the development of the disease lead to consider OA as a severe disease of the whole joint as an organ.1–3 The aetiology of knee…

Continue Reading A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Review doi: 10.1038/s12276-023-00965-7. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. jhk@catholic.ac.kr. 2 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. 3 Laboratory of Obesity and Aging Research,…

Continue Reading Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Key Amino Acid Residues of Mitochondrial Transcription Factor A Synergize with Abasic (AP) Site Dynamics To Facilitate AP-Lyase Reactions

Human mitochondrial DNA (mtDNA) encodes 37 essential genes and plays a critical role in mitochondrial and cellular functions. mtDNA is susceptible to damage by endogenous and exogenous chemicals. Damaged mtDNA molecules are counteracted by the redundancy, repair, and degradation of mtDNA. In response to difficult-to-repair or excessive amounts of DNA…

Continue Reading Key Amino Acid Residues of Mitochondrial Transcription Factor A Synergize with Abasic (AP) Site Dynamics To Facilitate AP-Lyase Reactions

Almost no peak output after peakcalling of mtDNA with MACS2

Almost no peak output after peakcalling of mtDNA with MACS2 0 I am new to the CHIP-seq analysis. I am basically trying to call peaks using MACS 2 with the proccessed data of mitochondrial DNA only in bedgraph format given in the accession number GSE48176 under the link www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48176. I…

Continue Reading Almost no peak output after peakcalling of mtDNA with MACS2

[E::idx_find_and_load] warning in htseq-count

[E::idx_find_and_load] warning in htseq-count 0 I am running the htseq-count but get the [E::idx_find_and_load] warning. The bam files were sorted with name but without index. It is not required for index when running htseq-count, correct? *CODE: htseq-count -f bam \ -s no \ -t exon \ -m union \ -i…

Continue Reading [E::idx_find_and_load] warning in htseq-count

The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice | Cell Communication and Signaling

Malhi GS, Mann JJ. Depression. Lancet. 2018;392:2299–312. Article  Google Scholar  Wang B, Zhang H, Cao X. Research progress of non-monoamine antidepressants. Stress Brain. 2021;1:128–44. Article  Google Scholar  Coccaro EF. New hope for patients with major depressive disorder? N Engl J Med. 2019;381:980–1. Article  Google Scholar  Cai N, Chang S, Li…

Continue Reading The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice | Cell Communication and Signaling

Origins and diversification of animal innate immune responses against viral infections

Harvey, E. & Holmes, E. C. Diversity and evolution of the animal virome. Nat. Rev. Microbiol. 20, 321–334 (2022). Article  CAS  Google Scholar  Flajnik, M. F. & du Pasquier, L. Evolution of innate and adaptive immunity: can we draw a line? Trends Immunol. 25, 640–644 (2004). Article  CAS  Google Scholar …

Continue Reading Origins and diversification of animal innate immune responses against viral infections

Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis | Journal of Neuroinflammation

Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8. doi.org/10.1097/00001199-200609000-00001. Article  PubMed  Google Scholar  Cao HQ, Dong ED. An update on spinal cord injury research. Neurosci Bull. 2013;29:94–102. doi.org/10.1007/s12264-012-1277-8. Article  PubMed  Google Scholar  O’Donnell MJ, Xavier D,…

Continue Reading Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis | Journal of Neuroinflammation

As of July 2015, the VCFtools project has been moved to github! Please visit the new website here: vcftools.github.io/man_0112a.html

NAME SYNOPSIS DESCRIPTION EXAMPLES BASIC OPTIONS SITE FILTERING OPTIONS INDIVIDUAL FILTERING OPTIONS GENOTYPE FILTERING OPTIONS OUTPUT OPTIONS COMPARISON OPTIONS AUTHOR NAME VCFtools v0.1.12a − Utilities for the variant call format (VCF) and binary variant call format (BCF) SYNOPSIS vcftools [ –vcf FILE | –gzvcf FILE | –bcf FILE]…

Continue Reading As of July 2015, the VCFtools project has been moved to github! Please visit the new website here: vcftools.github.io/man_0112a.html

Probing the Mammalian Mitochondrial Nucleoid

dc.contributor.author Rajala, Nina dc.date.accessioned 2015-04-29T04:47:49Z dc.date.available 2015-04-29T04:47:49Z dc.date.issued 2015 dc.identifier.isbn 978-951-44-9794-0 – dc.identifier.uri trepo.tuni.fi/handle/10024/96996 dc.description.abstract Mitokondrioiden tärkein tehtävä on energian tuottaminen. Mitokondriot ovat solujen hengityskeskuksia, joissa 90 % tarvitsemastamme energiasta tuotetaan oksidatiivisen fosforylaation kautta elektroninsiirtoketjua apuna käyttäen. Kun mitokondriot eivät toimi kunnolla, tuloksena voi olla energiakriisi, erityisesti lihaksissa, aivoissa ja…

Continue Reading Probing the Mammalian Mitochondrial Nucleoid

Dissertations.se: MITOCHONDRIAL DNA REPLICATION

Showing result 1 – 5 of 29 swedish dissertations containing the words Mitochondrial DNA replication. Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA;…

Continue Reading Dissertations.se: MITOCHONDRIAL DNA REPLICATION

Dissertations.se: INITIATION OF DNA REPLICATION

Showing result 1 – 5 of 43 swedish dissertations containing the words initiation of DNA replication. Author : Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication; Abstract : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and…

Continue Reading Dissertations.se: INITIATION OF DNA REPLICATION

The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction,…

Continue Reading The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Dissertations.se: MITOCHONDRIAL CARDIOMYOPATHY

Showing result 1 – 5 of 9 swedish dissertations containing the words mitochondrial cardiomyopathy. Author : Gittan Kollberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase…

Continue Reading Dissertations.se: MITOCHONDRIAL CARDIOMYOPATHY

Korean red ginseng reduces ageing-related issues in postmenopausal women

Although no exact mechanism has been identified for the ageing process in women after menopause, several epidemiological studies have shown that there are many diseases related to ageing in postmenopausal women, such as type 2 diabetes and cardiovascular disease​, both of which are closely linked to oxidative stress and chronic…

Continue Reading Korean red ginseng reduces ageing-related issues in postmenopausal women

mitochondrial dna damage triggers an ifn mediated immune response

2.6 Mitochondrial Damage-Induced Mitochondrial DNA Release is Central to Chronic Kidney Disease-Induced Type-I-Interferon Response in Vascular Smooth Muscle Cells DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS-STING pathway. This is thought to be mediated by the presence 75 of leaked mitochondrial DNA…

Continue Reading mitochondrial dna damage triggers an ifn mediated immune response