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Tag: TIDE
Boosting Immune Response with Non-Viral Gene Electrotransfer
A groundbreaking study published in Nature Cancer has unveiled a novel approach to tumor treatment. By leveraging local intratumor delivery with electroporation of low levels of plasmids encoding molecules, researchers have discovered an antitumor effect that does not result in systemic toxicity. Upregulating MHC-I and PD-L1: The Keys to Unlocking…
Biotech job market 2024: what to expect?
The past year saw a string of pipeline cuts and downsizing plans strike the biotech job market. Have layoffs spooked young professionals looking for a way into the industry, and does the employment landscape seem to be looking up this year? Employment in the life sciences industry had hit a…
Amid second-largest wave of COVID infections in the US, Florida’s surgeon general calls to halt mRNA vaccines
On Friday, wastewater data from Biobot Analytics and the US Centers for Disease Control and Prevention (CDC) affirmed that the US has now reached its second-highest level of COVID-19 infections of the pandemic. It is anticipated that by midweek, rates of infections will reach 2 million per day with approximately…
Old convertible cars for sale near me
Catalytic converters are an important part of a car’s emission system, and they can be recycled for scrap metal. Selling catalytic converter scrap can be a lucrative business, but there are a few things to consider in order to maximize prof…1968 Oldsmobile 442 Beautiful Vintage Convertible! 75,894km Specs: Engine Size…
Smart glasses are becoming useful in a way I didn’t expect
Let’s be real. Most “smart glasses” you can buy today suck. At best, they’re useful in a handful of niche situations and, even then, most of them don’t do their job very well. Even the best smart glasses are pretty mid, but that tide is changing, and it’s changing fast….
Flooding, gusty winds forecast for Miami, Fort Lauderdale, Palm Beach. Secure holiday trim
The National Weather Service in Miami issued a flood watch Wednesday for large parts of South Florida while forecasters warned gusty winds plaguing the region over the next several days could blow away your holiday decorations. Flooding is possible in the coastal and metropolitan areas of Miami-Dade, Broward and Palm…
Flood watch issued for Miami, Fort Lauderdale and Palm Beach
Two men walk through a flood at West 14th Avenue and West 29 Street in Hialeah on Thursday, Nov. 16, 2023. Pedro Portal pportal@miamiherald.com The National Weather Service in Miami issued a flood watch Wednesday for large parts of South Florida while forecasters warned gusty winds could blow away your…
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma
CHEK2 expression increased in cancer tissues First, the expression levels of CHEK2 in different tumor types in the TIMER database were evaluated. All tumors except for chromophobe renal cell carcinoma (KICH) showed elevated levels of CHEK2 expression compared to normal cells (Fig. 1A). Similarly, CHEK2 protein expression was upregulated in all…
The coming AI-enabled pharma revolution
In today’s challenging economic climate, every company is tasked with achieving more with limited resources. During this timely roundtable discussion, The Coming AI-Enabled Pharma Revolution, sponsored by Boundless Life Sciences Group, industry leaders explored the transformative potential of AI to enhance clinical and commercial processes, boost productivity, maximize ROI and…
OpenAI’s gen AI updates threaten the survival of many open source firms
With several new updates announced at its first developer conference, OpenAI — the creator of ChatGPT and GPT-4 — could be threatening the survival of several open source software providers. The company released several updates, including a new Assistants API, new modalities, custom GPTs, a new store for models, and new pricing…
Haplotype and phylogenetic diversity using mitochondrial 12S rRNA gene marker in Bali cattle | Suselowati
Haplotype and phylogenetic diversity using mitochondrial 12S rRNA gene marker in Bali cattle T. Suselowati – Graduate School of Animal Science Faculty, IPB University, Indonesia R. R. Noor – Department of Animal Production and Technology, Faculty of Animal Science, IPB University, Indonesia *J. Jakaria – Department of Animal Production and…
AI regulation arrives, SBF goes down and gen AI lifts earnings outlooks
That was quick: It’s a wrap for Sam Bankman-Fried, whose jury took only about four hours to decide he’s guilty on all counts. Now, pending an appeal, the main question is how long he’ll be behind bars. SBF’s conviction was the capper for a busy week. Regulations finally came to…
An Interview with Fyodor Urnov
By Jonathan D. Grinstein, PhD Fyodor Urnov, PhD, is a pioneer in the field of genome editing and one of the scientists most invested in expanding the availability and utility of CRISPR-based therapies to the broadest possible population. He envisions a world in which genome editing can treat the nearly…
major antitrust cases in recent years
Antitrust laws are put in place to prevent unlawful activities like price fixing, as well as monopolies from forming, typically tied to big pharma. If these powerful companies were to swallow smaller biotechs in an attempt to fix prices, it would stifle competition, result in limited options for consumers, thereby…
Meta’s Q3 Blowout Shows It’s The Best AI Company You Didn’t Know About (NASDAQ:META)
Kelly Sullivan After a treacherous ride through 2022, Mark Zuckerberg has learned his lesson to not go against the tide with his “Metaverse at all costs” strategy, and instead directly address some of market’s hottest demands – namely, profitable growth and AI. And the stock (NASDAQ:META) has continued to build…
FitnessGenes DNA: at home testing for individuals
Revolutionise your health and athletics performances by gaining a greater insight into your own body A British biotechnology firm is aiming to turn the tide with an at-home DNA test that makes personalised food, sleep and exercise recommendations based on an individual’s unique genetic make-up to help people to live healthier, longer…
Identification of lactate regulation pattern on tumor immune infiltration, therapy response, and DNA methylation in diffuse large B-cell lymphoma
Background: Lactate, produced through glycolytic metabolism in the tumor microenvironment (TME), is implicated in tumorigenesis and progression in diverse cancers. However, the impact of lactate on the remodeling of the TME in diffuse large B-cell lymphoma (DLBCL) and its implications for therapy options remain unclear. Method: A lactate-related (LAR) scoring…
Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells
Credit: CC0 Public Domain Cancer immunotherapy drugs called PD-1 inhibitors are widely used to stimulate the immune system to fight cancer, but many patients either don’t respond or develop resistance to them. A new small-molecule drug candidate being tested in an early-stage clinical trial aims to improve patient responses to…
Vertex AI forecasting | Google Cloud Blog
Compared to the Vertex AI flagship deep learning forecasting model (Learn2Learn), the TiDE architecture provides a 10x training throughput improvement (and in some cases up to 25x). The prediction throughput is also improved substantially, ranging from 3x to 10x in common tasks. This upgrade allows completion of most training jobs…
Your favorite websites are at war against AI chatbots like ChatGPT
Generative AI is thought of as the technological evolution to ferry us into a new age. Any person who uses a chatbot such as ChatGPT or Google Bard might agree, but no new technology is without its vehement naysayers. The war going on between AI chatbots like ChatGPT and the…
Solved A PhD student leaving for vacation has asked an
A PhD student leaving for vacation has asked an undergraduate student to perform daily media changesfor his iPSCs while he is gone. The culture is happening in 12-well plates where a volume of 2 mL is optimal.On Saturday, when changing the media, the undergraduate decides to add 4 ml of…
Abundant Sulfitobacter marine bacteria protect Emiliania huxleyi algae from pathogenic bacteria
Ramanan R, Kim BH, Cho DH, Oh HM, Kim HS. Algae–bacteria interactions: evolution, ecology and emerging applications. Biotechnol Adv. 2016;34:14–29. Article CAS PubMed Google Scholar Falkowski PG, Fenchel T, Delong EF. The microbial engines that drive earth’s biogeochemical cycles. Science. 2008;320:1034–9. Article CAS PubMed Google Scholar Buchan A, LeCleir GR,…
DeepMind AI Hunts Down the DNA Mutations Behind Genetic Disease
Proteins are like Spider-Man in the multiverse. The underlying story is the same: each building block of a protein is based on a three-letter DNA code. However, change one letter, and the same protein becomes a different version of itself. If we’re lucky, some of these mutants can still perform…
A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae
In a recent study published in Scientific Reports, a group of researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein (MOMP) protein of Chlamydia pneumoniae (C. pneumoniae; Cpn) using immunoinformatics. They assessed the vaccine’s interaction with immune receptors and expressed it in silico on a baculovirus…
Scientists find evidence of sea star species hybridization
Scientists have long suspected two species of sea stars — commonly referred to as starfish — along rocky European and North American coastlines of crossbreeding in the cool waters of the North Atlantic Ocean. Now, according to recently analyzed genomic data, hybrid starfish are living and thriving, from the shores…
From a remote tribal hamlet in Idukki, emerges a Special Tahsildar
Life was a struggle for V. Shinu, who joined the government service as Special Tahsildar in charge of land acquisition for the National Highway in the Kasaragod collectorate recently. A member of Urali, a tribal community from a small hamlet at Vanchivayal inside the Periyar Tiger Sanctuary in Idukki, his…
Who is King County John Doe (2017)?
Summary In December 2017 and January 2018, the partial remains of an unknown individual washed ashore near Four Mile Rock in Seattle, Washington. Four Mile Rock is a twenty-foot tall glacially deposited rock located four nautical miles from an early Seattle landmark. It is located near Discovery Park on the…
TNFSF10, an autophagy related gene, was a prognostic and immune infiltration marker in skin cutaneous melanoma
Autophagy exerts a pivotal effect on skin cutaneous melanoma (SKCM). This study was aimed to investigate the expression of autophagy related genes (ARGs) in SKCM as well as its clinical value. Differentially expressed (DE) ARGs were downloaded from the intersection of SKCM data in GEPIA2 database and ARGs in Human…
AI Deep Dives Into Coral Reef Conservation
With coral reefs in rapid decline across the globe, researchers from the University of Hawaii at Mānoa have pioneered an AI-based surveying tool that monitors reef health from the sky. Using deep learning models and high-resolution satellite imagery powered by NVIDIA GPUs, the researchers have developed a new method for…
The Delights Of The Pfizer/Moderna Catfight
Authored by Robert Malone via The Brownstone Institute, I am a bit embarrassed to admit that I am taking a perverse pleasure in watching this catfight between Pfizer/BioNTech and Moderna play out. Not to gloat, but I find it validating and rather satisfying to watch these companies file lawsuits and…
Cloud giants eye a potential windfall in AI at the network edge
David Linthicum is enjoying a well-earned “I told you so.” Six years ago the chief cloud strategy officer at Deloitte Consulting LLP predicted that the then-fledgling edge computing market would create a significant growth opportunity for cloud computing giants. That went against a popular tide of opinion at the time…
Hope rises over use of gene therapy to reverse blindness
Year in, year out, several diseases, abnormalities and genetic conditions have left sufferers to lead unproductive lives, live with the stigma, pain and in some cases, meet their untimely death. Studies revealed that genetic diseases affect people all over the world. The World Health Organisation estimated that between 70 and…
Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system | BMC Biotechnology
Isolation of PFFs PFFs were isolated from the 30-day-old fetuses of a Large White pig purchased from Fujian Yongcheng Agricultrual & Animal Husbandry Science and Technology Group Co., Ltd (Jiangxi Province, China). Briefly, the sow was euthanized by intravenous injection of potassium chloride solution (100 mg/kg) under anesthesia by an intramuscular…
Phase 3 of Sibu flood mitigation plan to protect 308 hectares, 16,000 people
Abang Johari (second right) is briefed on the development of Sibu Flood Mitigation Plan Phase 3. Seen behind the Premier is Dr Sim. – Photo by Peter Boon. SIBU (Aug 8): The completion of Phase 3 of the Sibu Flood Mitigation Plan is expected to be able to protect an…
High-Efficiency Gene Disruption in Primary Bone Marrow-Derived Macrophages Using Electroporated Cas9-sgRNA Complexes
The IVT template is a 127 bp PCR product (Figure 1B). The full-length IVT product is a 98 nt RNA, which migrates similarly to a 70 bp double-stranded DNA fragment (Figure 1C). After electroporation, the cells should be >90% viable, with a total cell count of >70% of the starting…
The genome of antibiotic-producing colonies of the Pelagophyte alga Chrysophaeum taylorii reveals a diverse and non-canonical capacity for secondary metabolism
Keffer, J. L. et al. Geographic variability and anti-Staphylococcal activity of the chrysophaentins and their synthetic fragments. Mar. Drugs 10, 1103–1125 (2012). Article PubMed PubMed Central Google Scholar Lobban, C. S. & Tsuda, R. T. Revised checklist of benthic marine macroalgae and seagrasses of Guam and Micronesia. Micronesica 35–36, 54–99…
r – Trouble making a particular sampling schematic diagram using ggplot2 and ggforce
I’ve been trying to make a reproducible version of a diagram of the sampling scheme for a particular field project, mirroring this version that I made by hand in PowerPoint: Original sampling schematic figure Geom_mark_rect from ggforce has been super helpful for creating boxes around the collections of points. However,…
Metagenomic surveillance for bacterial tick-borne pathogens using nanopore adaptive sampling
Albertsen, M. Long-read metagenomics paves the way toward a complete microbial tree of life. Nat. Methods 20, 30–31 (2023). Article CAS PubMed Google Scholar van Dijk, E. L., Auger, H., Jaszczyszyn, Y. & Thermes, C. T. years of next-generation sequencing technology. Trends Genet. 30, 418–426 (2014). Article PubMed Google Scholar …
Phylogenomic analysis of transcriptomic sequences of mitochondria and chloroplasts of essential brown algae (Phaeophyceae) in China
Burger G, Nedelcu A M. 2012. Mitochondrial genomes of algae. Berlin: Springer Science & Business Media B V, 127-157 Burki F, Flegontov P, Oborník M, et al. 2012. Re-evaluating the green versus red signal in eukaryotes with secondary plastid of red…
The Century of Biology – Maddyness UK
Around the globe, scientists and engineers are harnessing the magnificent properties of living systems and organisms to conjure magic: cell-based meat; enzymes that convert waste into valuable minerals and chemicals; microbes that produce proteins with novel functions, and biofuels. What is driving this revolution? At a societal level, there is…
While Starting Up, Keep Your Passion Aside And See If The Idea Has Potential To Make Money: Sam Santhosh
Sam Santhosh, Founder of MedGenome Sam Santhosh is a self-made entrepreneur who has spent 20 years in the software industry followed by 15 years in biotech. He started his entrepreneurial career with US California Software Company Limited and took it public in India. He then wanted to go deep…
How the ALS Ice Bucket Challenge made a lasting impact
In the summer of 2014, the ALS Ice Bucket Challenge quite literally drenched the internet, quickly becoming what is now considered the largest social media movement in medical history. Seventeen million people uploaded videos of themselves to Facebook dumping buckets of ice water over their heads and challenging friends, family,…
Using Tumor Immune Dysfunction and Exclusion (TIDE)
Using Tumor Immune Dysfunction and Exclusion (TIDE) 0 I have multiple datasets with bulk RNA-seq and the metadata for response / no response to immune checkpoint blockade therapy. I want to use Tumor Immune Dysfunction and Exclusion, TIDE, in order to use the transcriptomic data, to predict response. In order…
In 30 years, NVIDIA died almost 3 times
“Run, don’t walk. Either you are running for food, or you are running from becoming food.” Jensen Huang’s recent speech to the graduating students of National Taiwan University (NTU) comes at a time right when NVIDIA is soaring high with its recent market cap valuation of close to $1 trillion….
Plasmid DNA Manufacturing To See Impressive Growth In Years Ahead
By Sharvari Rale, Fairfield Market Research The quest for the most effective disease treatments has become more urgent than ever. The global chronic disease burden is swelling at alarming rates, pointing to growing severity of the situation for the global healthcare system, economy, and public health. Prevalence of chronic conditions…
Google expands TensorFlow open-source tooling for accelerated machine learning development
Join top executives in San Francisco on July 11-12, to hear how leaders are integrating and optimizing AI investments for success. Learn More The big artificial intelligence (AI) news at Google I/O today is the launch of the company’s PaLM 2 large language model, but that’s not the only AI…
Gene editing: overhyped or unstoppable tide?
Only 10 years since Crispr made a splash as a possible therapeutic approach, the first product using Crispr/Cas9 gene editing is on the verge of approval. Vertex and Crispr Therapeutics’ exa-cel, for sickle cell anaemia and beta thalassaemia, has been filed with US and European regulators. Alongside this breakneck speed…
GitLab and Google Cloud partner to power generative AI-assisted DevSecOps features
DevSecOps company GitLab Inc. today announced an expansion of its partnership with Google Cloud to deliver new generative artificial intelligence-powered features for developers directly within its platform while maintaining security and privacy standards. Generative AI is the technology that underlies OpenAI LP’s ChatGPT chatbot and Google Bard. It’s capable of…
3 Cash-Rich Biotech Stocks to Bet on for the Long Haul
The Federal Reserve’s recent interest rate hikes mean banks charge much higher interest rates for loans. The interest on loans can be considered the price of borrowing more money. And since acquiring cash now costs more money, it’s becoming much more complicated for companies to invest. For biotech stocks, the…
Unlocking global supply chains
A technician at Applied DNA Sciences testing samples to trace the raw materials. JOHNNY MILANO /The New York Times At a cotton gin in the San Joaquin Valley, in California, a boxy machine helps to spray a fine mist containing billions of molecules of DNA onto freshly cleaned Pima cotton….
How AI and DNA are unlocking the mysteries of global supply chains
At a cotton gin in the San Joaquin Valley, in California, a boxy machine helps to spray a fine mist containing billions of molecules of DNA onto freshly cleaned Pima cotton. That DNA will act as a kind of minuscule bar code, nestling amid the puffy fibres as they are…
Anthony Joshua – Phase 3
The third phase in the career of the biggest heavyweight ticket seller in boxing begins this Saturday (DAZN, 2 PM EST). It could end up being the most interesting phase of Joshua’s career. Or could it play out as an epilogue? The first person who will get a chance to…
Women in STEM challenges and opportunities
In this article to celebrate International Women’s Day, we asked women in STEM for their comments on the challenges they have faced in their careers so far, and how solutions can emerge from these challenges. We get advice from Fiona McLaughlin, CSO, Avacta Therapeutics; Maureen Coleman, chairman, CN Bio; Debora…
Remains found in fishing line by duck hunter in Washington State in 1979 finally identified
Skeletal remains found in tangled fishing line by a duck hunter in Washington State in 1979 have finally been identified thanks to DNA testing 43 years later DNA testing showed that the remains belonged to 29-year-old Gary Lee Haynie They were first found in January, 1979, near Spencer Island, south…
Remains found in Snohomish County over 40 years ago identified
A set of human remains that were found in Snohomish County in 1979 have been identified as those of an Everett man who had gone missing, the county announced late last week. The remains were found Jan. 3, 1979, by a duck hunter on tide flats near Spencer Island, just…
After 44 years, Spencer Island John Doe is Identified
Summary In January 1979, a duck hunter discovered human remains entangles in fishing line on the tide flats near Spencer Island just south of Marysville, Washington. The Snohomish County Coroner’s Office called the decedent “John Doe (79-1)” under Coroner’s case number 79-1-7. The Snohomish County Sheriff’s Office responded to the…
Bioinformatics construction and experimental validation of a cuproptosis-related lncRNA prognostic model in lung adenocarcinoma for immunotherapy response prediction
Data collection and processing The RNA-sequencing data, clinical information and simple nucleotide variation of LUAD patients were retrieved from TCGA database (portal.gdc.cancer.gov/, accessed April 8, 2022). Nineteen cuproptosis-related genes (CRG) were mainly collected from previous study, including LIPT1, GLS, NFE2L2, NLRP3, LIAS, ATP7B, ATP7A, SLC31A1, FDX1, LIPT2, DLD, DLAT, PDHA1,…
Spatial and NGS Dominate Proceedings at AGBT 2022
Attending the Advances in Genome Biology and Technology (AGBT) meeting in June 2022 in Orlando, FL, was like drinking from a firehose of genomic information. Or rather, two firehoses. The first let loose a steady stream of information about progress in spatial biology. Speakers shared their excitement over new discoveries,…
Scientists reckon they will be able to bring the woolly mammoth back from extinction in four years
Scientists reckon they will be able to bring the woolly mammoth back from extinction in four years. (Image Credit: (colossal.com/mammoth/) The woolly mammoth (Mammuthus primigenius) was a legendary species of mammoth that went extinct roughly 10,000 years ago. They were one of the last in a line of mammoth species,…
IPA Reports Financial Results and Recent Business Highlights for Second Quarter Fiscal Year 2023
VICTORIA, British Columbia–(BUSINESS WIRE)–IPA (IMMUNOPRECISE ANTIBODIES LTD.) (the “Company” or “IPA”) (NASDAQ: IPA), an AI-driven biotherapeutic research and technology company, today announced financial results for second quarter fiscal year 2023, which ended October 31, 2022. “Our focus on accelerated revenue development and the sales integration of our in silico capabilities…
The Promise of RNA-Based Therapies
Published a day ago Submitted by CRB Decades of scientific progress in understanding the root cause of many formerly intractable diseases has opened up new treatment options, namely through RNA-based therapies. This second wave of biopharma, in which our understanding of the ways coding portions of our genome relate to…
Ozone API Hires New Head of Product To Lead Open Finance Development
Ozone API, developer of the leading standards-based open API software for Open Banking, is delighted to announce the appointment of Evghenii Malevanchuk as Head of Product. This key senior hire will bolster Ozone API’s international development team and support its delivery of world-class open API technology that enables banks to…
Patents on Measuring cfDNA to Detect Rejection of Transplanted Organs Held Invalid | Insights
When a person who has received an organ transplant experiences rejection, DNA from the transplanted organ is released into the bloodstream as the organ’s cells are attacked by the person’s immune system. The circulating DNA from the transplanted organ — referred to as cell-free DNA (cfDNA) — can be distinguished…
AIM brings innovations from labs to hospitals and masses
Human body like the Space is an endless frontier made even more complex by the irreversibility of life by the arrow of time. Similar to the mystery of origin of the Universe some problems in the human body are so complex, for example, the problem of qualia or the Hard…
bioinformatics vacancy
On the one hand, I really liked the diversity of the bioinformatics program, and, with a degree in bioinformatics, there are many possible career paths. Updated on 2 December 2021. Exact wages will depend on experience and the industry an individual works in. Working experience with structural antigen analyses and…
Bigelow Scientist On How Environmental DNA Could Help Maine Monitor Oceans
It’s called eDNA, the E stands for “environmental,” and the National Science Foundation is spending $20 million in Maine to see how it can be useful. Education and scientific institutions around the state are involved in the multiyear project, led by the University of Maine and the Bigelow Laboratory for…