Tag: XDR

Direct Detection of Fluoroquinolone Resistance in Sputum Samples from Tuberculosis Patients by High Resolution Melt Curve Analysis

WHO (2022) Global Tuberculosis Report. WHO (2022) WHO consolidated guidelines on tuberculosis, Module 4: Treatment- Drug-resistant tuberculosis treatment: 2022 update. WHO (2020) Meeting report of the WHO expert consultation on the definition of extensively drug-resistant tuberculosis. Jabeen K, Shakoor S, Hasan R (2015) Fluoroquinolone-resistant tuberculosis: implications in settings with weak…

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The genomic epidemiology of shigellosis in South Africa

Institue for Health Metrics and Evaluation. Global Burden of Disease. vizhub.healthdata.org/gbd-results/ 2019. Troeger, C. E. et al. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. Lancet Infect. Dis. 20, 37–59 (2020)….

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Apple M3 MacBook Pro teardown reveals its inner workings

Apple’s new M3 MacBook Pro range of laptops brings a significant advancement in computing technology, marking a new era for personal computing. The introduction of the M3, M3 Pro, and M3 Max chips within these devices is a leap forward, utilizing the industry’s first 3-nanometer technology. This groundbreaking move is…

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Where Cosmic Wonders and Tech Wackiness Collide

In a world where tech ‘game-changers’ are as common as memes, Apple has just dropped a bombshell- the new MacBook Pro line-up, featuring the magnificent M3 chips. So, let’s get ready as I am about to take you on a rollercoaster of information and some laughter as we dive into…

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BDQ resistance and molecular characterization of RR-TB

Enyu Tong,1,* Ying Zhou,1,* Zhengwei Liu,2 Yelei Zhu,2 Mingwu Zhang,2 Kunyang Wu,2 Junhang Pan,2 Jianmin Jiang1– 3 1School of Public Health, Hangzhou Normal University, Hangzhou, 311100, People’s Republic of China; 2Tuberculosis Control Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, People’s Republic of China; 3Key Laboratory of…

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Apple announces new 14-inch and 16-inch MacBook Pros with M3 chips

Today at the Scary Fast event, Apple announced updated 14-inch and 16-inch MacBook Pros with new M3 chips. These new chips deliver remarkable performance improvements over the previous M1 and M1 Pro/Max chips. The entry-level 14-inch MacBook Pro now features the M3 chip. Apple says it is up to 60%…

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Apple unveils new MacBook Pro featuring M3 chips

October 30, 2023 PRESS RELEASE Apple unveils the new MacBook Pro featuring the M3 family of chips, making the world’s best pro laptop even better 14-inch MacBook Pro with M3 now starts at $1,599 14- and 16-inch models with M3 Pro and M3 Max are available in a gorgeous new space black…

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Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis

Global clinical results A total of 50,723 M. tuberculosis isolates with WGS and drug susceptibility test data from 64 countries were analysed, and encompassed all major lineages (L4 48.3%, L2 27.6%, L3 11.8%, L1 9.1%) (Table 1, Fig. 1B). Lineage 2.2.1 (Beijing strain-type) is the most prevalent in four of six…

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Gromacs +cp2k installation – User discussions

GROMACS version: 2023.1 Hello. I am trying to compile gromacs-2023.1 with cp2k-2023.2, but I am not being able to link the fftwf3 library. So when I run the following command: cmake … -DBUILD_SHARED_LIBS=OFF -DGMXAPI=OFF -DGMX_INSTALL_NBLIB_API=OFF -DGMX_DOUBLE=ON -DGMX_FFT_LIBRARY=fftw3 -DFFTWF_LIBRARY=/home/edivaldo/cp2k/tools/toolchain/install/fftw-3.3.10/lib -DFFTWF_INCLUDE_DIR=/home/edivaldo/cp2k/tools/toolchain/install/fftw-3.3.10/include -DGMX_BLAS_USER=/home/edivaldo/cp2k/tools/toolchain/install/openblas-0.3.23/lib/libopenblas.a -DGMX_LAPACK_USER=/home/edivaldo/cp2k/tools/toolchain/install/scalapack-2.2.1/lib/libscalapack.a -DGMX_CP2K=ON -DCP2K_DIR=“/home/edivaldo/cp2k/lib/local/psmp” -DGMX_MPI=on I keep getting this warning:– The…

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GROMACS SYCL for Intel GPU – User discussions

GROMACS version: 2023.2GROMACS modification: Yes/NoHi,I’ve just install GROMACS with SYCL enabled, however, it seems like GROMACS cannot detect my GPU. My GPU is Intel Iris Xe Graphics, I’m using Ubuntu 22.04, CMake 3.27.4, and Intel oneAPI DPC++/C++ Compiler with MKL library 2023.2 for SYCL. Here it says SYCL is enabled:…

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Study finds surveillance system detected infection linked to eye drops months before outbreak declared

Credit: Unsplash/CC0 Public Domain An infectious diseases surveillance system created by University of Pittsburgh School of Medicine scientists and deployed at a UPMC hospital successfully flagged cases of a drug-resistant infection spread by eye drops months before national public health officials announced an outbreak. The findings, published today in The…

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Whole genome sequencing of drug resistance Mycobacterium tuberculosis from extra-pulmonary sites

Introduction Tuberculosis is a threat to human health caused by Mycobacterium tuberculosis that affected lung and other extra-pulmonary sites. There was an estimated 10.0 million people fell ill with TB, 1.2 million TB deaths among HIV-negative people, and an additional 251,000 deaths among HIV-positive people in 2018 (World Health Organization,…

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Whole genomic analysis of Mycobacterium tuberculosis

Introduction Tuberculosis (TB), caused by etiological Mycobacterium tuberculosis (Mtb), remains a public health worldwide and the leading cause of death from a single infectious agent until the COVID-19 pandemic.1 Previous studies revealed that M. tuberculosis originated in Africa and spread with human migration worldwide, it developed to a contemporary phylogeny…

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Antibiotics | Free Full-Text | Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Drug Resistance: A Retrospective Observational Study in Eastern China

1. Introduction Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). According to the “Global Tuberculosis Report” published by the World Health Organization (WHO) in 2022, 10.6 million new cases of TB worldwide were estimated in 2021, and 1.4 million people died from the disease. That year, 3.6%…

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Rapid detection of fluoroquinolone resistance in Mycobacterium tuberculosis using a novel multienzyme isothermal rapid assay

Global tuberculosis report 2022. Geneva: World Health Organization; 2022. licence: cc bY-Nc-sa 3.0 iGo. WHO operational handbook on tuberculosis. Module 4: treatment – drug-resistant tuberculosis treatment. Geneva: World Health Organization; 2020. Licence: CC BY-NC-SA 3.0 IGO. Chien JY, Chiu WY, Chien ST, Chiang CJ, Yu CJ, Hsueh PR. Mutations in…

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Drug resistance-associated mutations of M.TB

Introduction Tuberculosis (TB) is one of the most common causes of death and the leading cause of a single infectious agent.1 According to the 2022 Global TB Report of the World Health Organization (WHO), 10.6 million people were infected with TB in 2021, and although the annual number of deaths…

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Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster | BMC Infectious Diseases

Luo T, Comas I, Luo D, et al. Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese. Proc Natl Acad Sci USA. 2015;112:8136–41. Article  CAS  PubMed  PubMed Central  Google Scholar  Yin QQ, Liu HC, Jiao WW, et al. Evolutionary history and ongoing transmission of phylogenetic…

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A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia

Grimont PAD, W. F. X. Antigenic formulae of the Salmonella serovars, 9th ed. (World health organization collaborating center for reference and research on Salmonella, Insitut Pasteur, 2007). Gal-Mor, O., Boyle, E. C. & Grassl, G. A. Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ….

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Alcion Exits Stealth As ‘Modern AI-Driven Company’ Focused On Data Protection, Security, CEO Says

Storage News Joseph F. Kovar June 07, 2023, 01:20 PM EDT ‘You will be seeing a lot more work on the security side. We know very well how to do core backup and disaster recovery. … But we have also been spending a lot of time…

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Soniazid and ethionamide in Mycobacterium tuberculosis

Introduction Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death worldwide and caused 1.6 million deaths and 10.6 million new cases in 2021.1 Despite decades of efforts to adopt measures to control TB, achieving the goal of ending TB has been delayed due to a…

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Scientists identify mutations in DNA for early diagnosis of drug resistant bacteria for TB

Health care workers conducting a TB control awareness rally in Vijayawada. File | Photo Credit: K.V.S Giri Tuberculosis (TB) is a treatable disease, but drug resistance is now a major public health concern exacerbated by the emergence of multi and extensively drug-resistant TB. India has the highest burden of Multi-Drug…

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Working to tackle antibiotic resistant bacteria

The emergence of an XDR S. sonnei outbreak in the United Kingdom. A cgMLST dendrogram (midpoint rooted) of clinical isolates from the UK (n = 2,820) and genomic subtype references (n = 120) with the scale bar indicating distance in cgMLST alleles. Metadata tracks show patient and genomic features for isolates colored according to…

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Google Cloud Debuts Security-Focused Generative AI Platform

Security News Kyle Alspach April 24, 2023, 12:00 PM EDT The new Security AI Workbench is a set of generative AI tools that leverage a new security-specific large language model from Google. Google’s Next Generative AI In what Google Cloud is calling…

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Gromacs: src/gromacs/fileio Directory Reference

Directory dependency graph for fileio: This browser is not able to show SVG: try Firefox, Chrome, Safari, or Opera instead. Directories directory   tests   Files file   checkpoint.cpp   file   checkpoint.h   file   confio.cpp   file   confio.h   file   enxio.cpp   file   enxio.h  …

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Current role of application of Whole genome sequencing by NGS technology in drug resistant TB diagnosis and management, Health News, ET HealthWorld

By Dr Niranjan Patil New Delhi: Each DNA strand is made of 4 chemical units called nucleotide bases which compromise the GENETIC ALPHABET. These bases are Adenine(A), Guanine (G), Cytosine(C), and Thymine(T). The sequence/order of As, Gs, Cs, and Ts determines the meaning of the information encoded (also called as…

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Top Artificial Intelligence Companies to look out for in 2023

The market research firm IDC projected that the global AI market will reach a size of over half a trillion U.S. dollars by 2024.   Precedence research suggests that the AI market will grow to over 1.5 trillion U.S. dollars by 2030.   Artificial Intelligence (AI) has gripped the world entirely –…

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PAN-TB regimens to address growing TB drug resistance

By Dr. Charles Wells, head of therapeutics development at Gates Medical Research Institute As nearly one-quarter of the world’s population is presumed to be infected with Mycobacterium tuberculosis bacteria and are at risk for developing active tuberculosis (TB), the disease represents a major public health challenge globally.  As reported by…

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A 10-year microbiological study of Pseudomonas aeruginosa strains revealed the circulation of populations resistant to both carbapenems and quaternary ammonium compounds

P. aeruginosa bacterial strains Reference strains Four well-described and genome-available reference strains were used in the present study, ATCC27853 and ATCC15442, obtained from the American Type Culture Collection (ATCC), and PAO1 and PA14, from the collection of Institut Pasteur (Paris, France). Strain ATCC15442 is recommended for disinfectant susceptibility testing44, strain…

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Whole-genome sequencing-based analyses of drug-resistant Mycobacterium tuberculosis from Taiwan

Characteristics of the study population Among the 200 DR-TB cases, 146 (73.0%) cases were male, the median age was 66 (interquartile range = 55–78) years, 165 (82.5%) were new cases and 182 (91.0%) cases showed pulmonary TB (Table 1). The majority of DR-TB cases came from northern (74, 37.0%) Taiwan. Among the…

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P. aeruginosa retrieved from broiler chickens

Introduction Pseudomonas species are ubiquitous microorganisms that are retrieved from various origins, such as poultry, drinking water, domestic and wild animals, human cases, and different food products.1,2 Pseudomonas infections in poultry are of the highest significance as the infection might spread speedily among the poultry flocks resulting in elevated mortalities…

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Molecular epidemiology of CRKP | IDR

Introduction Klebsiella pneumoniae (Kp; K. pneumoniae) is an important hospital and community-acquired pathogen that primarily causes pneumonia, urinary tract infections, bloodstream-associated infections, meningitis, and pyogenic liver abscess.1–3 Carbapenem antibiotics represent the most important treatment for Enterobacteriaceae; however, with the widespread use of such antibiotics, carbapenem-resistant K. pneumoniae (CRKP) is increasingly…

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Rapid emergence of extensively drug-resistant Shigella sonnei in France

Antimicrobial susceptibility data of S. sonnei in France Our review of S. sonnei antimicrobial susceptibility data obtained between 2005 and 2021 (based on 7121 isolates received and confirmed at the French National Reference Center for E. coli, Shigella and Salmonella, FNRC-ESS, Institut Pasteur) revealed a sharp increase in the percentage…

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Whole-genome sequencing to characterize the genetic structure and transmission risk of Mycobacterium tuberculosis in Yichang city of China

Objective: The burden of both general and drug-resistant tuberculosis in rural areas is higher than that in urban areas in China. To characterize the genetic structure and transmission risk of Mycobacterium tuberculosis in rural China, we used whole genome sequencing to analyze clinical strains collected from patients in two counties…

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