Tag: xenografts

csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis | Parasites & Vectors

Human tissue samples The preoperative diagnosis of CS mainly relies on stool microscopy, enzyme-linked immunosorbent assay, or endoscopy. Fresh liver and intrahepatic bile duct specimens were collected from ICC patients with (CS-ICC group) and without (NC-ICC group) CS infection during partial hepatectomy at the First Hospital of Jilin University. Tumor tissues…

Continue Reading csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis | Parasites & Vectors

Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

Khan, S. et al. Role of recombinant DNA technology to improve life. Int. J. Genomics Proteomics 2016, 2405954 (2016). Google Scholar  Spolski, R., Li, P. & Leonard, W. J. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nat. Rev. Immunol. 18, 648–659 (2018). Article  CAS  PubMed  Google…

Continue Reading Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

mouse+human cells in 10x scRNA-seq

mouse+human cells in 10x scRNA-seq 1 Hi everyone, I’m analyzing 10x scRNA-seq data generated from xenografts (mouse + human tissues). I have the following workflow to label cells as either mouse or human: Align 10x scRNA-seq data to mouse+human combined genome using cellranger count. Use the file generated by cellranger…

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In silico study about the influence of electroporation parameters on the cellular internalization, spatial uniformity, and cytotoxic effects of chemotherapeutic drugs using the Method of Fundamental Solutions

Batista Napotnik T, Miklavčič D (2018) In vitro electroporation detection methods – an overview. Bioelectrochemistry 120:166–182. doi.org/10.1016/j.bioelechem.2017.12.005 Article  CAS  PubMed  Google Scholar  Kotnik T, Rems L, Tarek M, Miklavčič D (2019) Membrane electroporation and electropermeabilization: mechanisms and models. Annu Rev Biophys 48(1):63–91. doi.org/10.1146/annurev-biophys-052118-115451 Article  CAS  PubMed  Google Scholar  Rems L,…

Continue Reading In silico study about the influence of electroporation parameters on the cellular internalization, spatial uniformity, and cytotoxic effects of chemotherapeutic drugs using the Method of Fundamental Solutions

Biomedicines | Free Full-Text | Association between SMAD4 Mutations and GATA6 Expression in Paired Pancreatic Ductal Adenocarcinoma Tumor Specimens: Data from Two Independent Molecularly-Characterized Cohorts

1. Introduction Pancreatic ductal adenocarcinoma (PDAC) has one of the highest case-specific mortality rates of all cancers [1]. Although resection remains the only curative therapy for PDAC, improvements in long-term survival are attributable to advances in systemic treatment [2,3,4,5]. Currently, 5-fluorouracil-based (i.e., with irinotecan and oxaliplatin as FOLFIRINOX) or gemcitabine-based…

Continue Reading Biomedicines | Free Full-Text | Association between SMAD4 Mutations and GATA6 Expression in Paired Pancreatic Ductal Adenocarcinoma Tumor Specimens: Data from Two Independent Molecularly-Characterized Cohorts

The Hidden Mechanisms Behind Rapid Tumor Evolution: AR Amplification on Extrachromosomal DNA I Prostate Cancer

Read the Full Video Transcript Andrea Miyahira: Hi everyone, I’m Andrea Miyahira at the Prostate Cancer Foundation. Presenting today is Dr. Scott Dehm, a professor at the University of Minnesota on his recent paper, “Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer,” published…

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Houston, Texas (US) job with Baylor College of Medicine (BCM)

Successful candidates will be recent PhD graduates with high levels of curiosity and who are interested in making fundamental discoveries in understanding the molecular biology and developmental origins of pediatric brain tumors.Evaluates and analyzes data.Summarizes research findings and publish results in research journals. Develops and optimizes protocols for the lab…

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Postdoctoral Associate- Bioinformatics/Genomics – Houston, Texas (US) job with Baylor College of Medicine (BCM)

The successful candidate will have opportunities to generate, analyze and mine data using a variety of approaches, including single-cell and spatial genomic assays.Generates new data using advanced genomic tools and analyze/mine other available resources.Summarizes research findings, prepares manuscripts for publication and publishes results in peer-reviewed research journals.Maintains laboratory operations. Experience…

Continue Reading Postdoctoral Associate- Bioinformatics/Genomics – Houston, Texas (US) job with Baylor College of Medicine (BCM)

An Intrabody against B-Cell Receptor-Associated Protein 31 (BAP31) Suppresses the Glycosylation of the Epithelial Cell-Adhesion Molecule (EpCAM) via Affecting the Formation of the Sec61-Translocon-Associated Protein (TRAP) Complex

. 2023 Sep 30;24(19):14787. doi: 10.3390/ijms241914787. Affiliations Expand Affiliation 1 College of Life Science and Health, Northeastern University, 195 Chuangxin Road, Hunnan District, Shenyang 110819, China. Item in Clipboard Tianyi Wang et al. Int J Mol Sci. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 Sep 30;24(19):14787. doi:…

Continue Reading An Intrabody against B-Cell Receptor-Associated Protein 31 (BAP31) Suppresses the Glycosylation of the Epithelial Cell-Adhesion Molecule (EpCAM) via Affecting the Formation of the Sec61-Translocon-Associated Protein (TRAP) Complex

Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer

Mice strains Six- to eight-week-old (age), 20–25-g (weight), both male and female (sex) mice were used for tumor xenografts generation and in vivo efficacy studies as described in the text (see Table 3). Athymic Nude (Envigo) Foxn1nu/Foxn1+ or NOD.Cg Prkdcscid Il2rgtm1Wjl/SzJ also called NSG mice were used. All animal procedures were…

Continue Reading Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer

IJMS | Free Full-Text | The cGAS/STING/IFN-1 Response in Squamous Head and Neck Cancer Cells after Genotoxic Challenges and Abrogation of the ATR-Chk1 and Fanconi Anemia Axis

Received: 11 September 2023 / Revised: 28 September 2023 / Accepted: 29 September 2023 / Published: 4 October 2023 Round 1 Reviewer 1 Report This article proposes to investigate the role of the cGSAS/STING/IFN-1 signaling pathway in the induction of tumor immune responses following DNA-damaging anticancer therapies such as CDDP…

Continue Reading IJMS | Free Full-Text | The cGAS/STING/IFN-1 Response in Squamous Head and Neck Cancer Cells after Genotoxic Challenges and Abrogation of the ATR-Chk1 and Fanconi Anemia Axis

Silencing Epigenetic Complexes Re-sensitizes Drug-Resistant Cancer Cells

Lung cancers often become resistant to targeted drug therapies. Researchers discovered a way to overcome one type of epigenetic resistance. Targeted anti-cancer therapies dramatically improve patient outcomes in EGFR-mutant lung adenocarcinomas,1 but many tumors acquire resistance to these drugs over time. Because there are numerous ways in which cancers become…

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Tango Therapeutics to Highlight Preclinical Data on Precision Oncology Pipeline at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Tango Therapeutics, Inc. BOSTON, Sept. 18, 2023 (GLOBE NEWSWIRE) — Tango Therapeutics, Inc. (NASDAQ: TNGX), a clinical-stage biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, today announced that five abstracts have been selected for poster presentations at the AACR-NCI-EORTC International Conference on Molecular Targets…

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Chemoresistance pathways in DLBCL | Blood

In this issue of Blood, Zhou et al reveal the role of KLHL6 inactivation in chemoresistance in diffuse large B-cell lymphoma (DLBCL).1 KLH6 is a cullin-ring ubiquitin type 3 ligase and a central player in the ubiquitin proteasome system, a cellular system that targets proteins for subsequent degradation, thereby limiting their…

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Bioprosthetics Market is Growing at 11% CAGR to Top USD 16.30 Billon by 2033

PRESS RELEASE Published September 14, 2023 The global bioprosthetics market boasts a valuation of US$ 5.74 billion in 2023, and over the next decade, it is expected to demonstrate remarkable growth with an impressive Compound Annual Growth Rate (CAGR) of 11%. By the close of 2033, the market is projected…

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Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi.org/10.3322/caac.21660. Article  PubMed  Google Scholar  Khan MA, Hakeem AR, Scott N, Saunders RN. Significance…

Continue Reading Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer

Computational optimization of antibody humanness and stability by systematic energy-based ranking

Raybould, M. I. J. et al. Thera-SAbDab: the therapeutic structural antibody database. Nucleic Acids Res. 48, D383–D388 (2020). Article  CAS  PubMed  Google Scholar  Schroff, R. W., Foon, K. A., Beatty, S. M., Oldham, R. K. & Morgan, A. C. Jr Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy….

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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

SF3B1 MUT cells show selective sensitivity to PARP inhibitors To identify candidate therapeutic targets for cancers with SF3B1 hotspot mutations, we utilized the leukemia K562K700E (SF3B1K700E) and parental (SF3B1WT) isogenic cells1, to model one of the most prevalent SF3B1 hotspot mutations seen in patients8,19,20 (Fig. 1a,b and Supplementary Fig. 1a)….

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PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes

Salipante, S. J. & Horwitz, M. S. Phylogenetic fate mapping. Proc. Natl Acad. Sci. USA 103, 5448–5453 (2006). Article  CAS  PubMed  PubMed Central  Google Scholar  Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64–119…

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From the cancer research bench to the vascular disease bedside

From penicillin to CRISPR, the greatest scientific discoveries often have the humblest origin stories. Who knew that a little fungal contamination or a bacterial defense system would revolutionize human health and medicine? Pau Castel, a cancer researcher at New York University, has experienced this serendipity in his own lab. When…

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CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

General Lab Operation The assays were performed by experienced individuals throughout the course of the study. The study was performed using established laboratory protocols covering the processing, freezing, storage and thawing of cells as well as the staining procedure, data acquisition and gating strategy. Additional data beyond the data found…

Continue Reading CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

ICML 2023 Meeting: CFT7455 in NHL Preclinical Presentation

CFT7455: A novel IKZF1/3 degrader, demonstrates potent anti-tumor activity in peripheral and CNS models of non-Hodgkin’s lymphoma as a single agent or in combination with clinically approved agents Samantha Perino, R. Jason Kirby, Roman V. Agafonov, Prasoon Chaturvedi, Scott J. Eron, Andrew Good, June A. Hart, Minsheng…

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Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

Read the Full Video Transcript Andrea Miyahira: Welcome. I’m Andrea Miyahira and I’m the senior director of Global Research and Scientific Communications at the Prostate Cancer Foundation. Today I’m joined by Dr. Gavin Ha, an assistant professor at Fred Hutchinson Cancer Center and the PCF 2019 Young Investigator. Dr. Ha’s…

Continue Reading Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway | Stem Cell Research & Therapy

Microarray-based expression analysis and GEO database analysis The DLBCL-related miRNA expression profiles of GSE29493 and GSE40239 were retrieved from the Gene Expression Omnibus (GEO) database (www.ncbi.nlm.nih.gov/geo/). MiR-124’s pan cancer analysis is conducted through online websites (www.picb.ac.cn/dbDEMC/). Bioinformatics predicted NFATc1 as the target of miR-124-3p The miRbase (www.mirbase.org/), miRDB (mirdb.org), and…

Continue Reading Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway | Stem Cell Research & Therapy

Bioinformatics Tool for Tracking Tumor-Immune Interactions Could Be Useful for Guiding Therapy

NEW YORK – A bioinformatics tool developed by researchers at MD Anderson Cancer Center may help researchers find interactions between tumor-associated genes and immune checkpoints that are predictive of immunotherapy response. Immune checkpoints that are associated with tumor-related processes and immune phenotypes are known to be drivers of immune evasion…

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IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma

Differential expression analysis We downloaded GSE125361 (n = 48) microarray data from the Gene Expression Omnibus (GEO) database, which included 45 myeloma samples and 3 controls, for expression analysis of IL5RA in cancer16. Additionally, we analyzed the expression of IL5RA in smoldering myeloma (SMM) patients who progressed to active MM (n = 10) and…

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Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

Molecular profiling reveals common changes in matched pairs of HNSCC primary tumor and metastasis-derived cell lines Identification of both genetic and functional differences between primary and metastatic variants of HNSCC would be enabled by in vitro models derived independently from these sites from the same patient. Unfortunately, HNSCC tumor cells…

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Mice Model Market Research Report 2023: A $2.7 Billion

Dublin, May 12, 2023 (GLOBE NEWSWIRE) — The “Mice Model Market by Model Types & Services (Inbred Mice, Genetically Engineered Mice), Technology (Microinjection, Nuclear Transfer, CRISPR/CAS9), Application (PDx Models, Drug Discovery), End User (Pharma, Biotech, CROs, CDMOs) – Global Forecast to 2028” report has been added to ResearchAndMarkets.com‘s offering. The…

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Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation | Clinical Epigenetics

5-Azacytidine pretreatment resensitizes cisplatin-resistant DLBCL cell lines to cisplatin to varying degrees A platinum-based anti-neoplastic agent is an essential component of salvage regimens for aggressive lymphomas, for example, rituximab, gemcitabine, dexamethasone, and cisplatin (R-GDP) for relapsed/refractory DLBCL and Hodgkin lymphoma [21]. As a single agent in humans, cisplatin is administered…

Continue Reading Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation | Clinical Epigenetics

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

doi: 10.1158/2643-3230.BCD-22-0167. Online ahead of print. Andriana G Kotini #  1   2   3   4 , Saul Carcamo #  1   5 , Nataly Cruz-Rodriguez #  1   2   3   4 , Malgorzata Olszewska  1   2   3   4 , Tiansu Wang  1   2   3   4 , Deniz Demircioglu …

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Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting | DNA RNA and Cells

Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting Details Category: DNA RNA and Cells Published on Tuesday, 18 April 2023 10:14 Hits: 247 — CB-012 genome-edited armoring strategy significantly reduced tumor burden and improved overall survival in AML…

Continue Reading Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting | DNA RNA and Cells

Human Acute Myeloid Leukemia Reportedly Closely Mimicked for First Time by Transformative Models

Tisch Cancer Center scientists report that they have developed novel models of the deadliest blood cancer, acute myeloid leukemia (AML), creating a “transformative resource” to study this cancer and eventually its drug response and drug resistance, according to research presented at the annual meeting of the American Association of Cancer…

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Data of InnoCare’s Robust Oncology Pipelines Presented at the 2023 AACR Annual Meeting

News and research before you hear about it on CNBC and others. Claim your 1-week free trial to StreetInsider Premium here. BEIJING–(BUSINESS WIRE)– Data of InnoCare’s (HKEX: 09969; SSE: 688428) robust oncology pipelines were presented at the 2023 American Association for Cancer Research (AACR) Annual Meeting. Oral Presentation: ICP-490 is…

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Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting

Caribou Biosciences, Inc. — CB-012 genome-edited armoring strategy significantly reduced tumor burden and improved overall survival in AML xenograft models — — CB-012 IND-enabling studies ongoing; IND submission in r/r AML planned for H2 2023 — BERKELEY, Calif., April 17, 2023 (GLOBE NEWSWIRE) — Caribou Biosciences, Inc. (Nasdaq: CRBU), a…

Continue Reading Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting

Catamaran Bio Announces Preclinical Data from Allogeneic

Two allogeneic CAR-NK cell therapies demonstrate significant efficacy in tumor xenograft models Data underscore potential of TAILWIND® platform to create effective CAR-NK treatments for solid tumors BOSTON, April 11, 2023 (GLOBE NEWSWIRE) — Catamaran Bio, Inc., a biotechnology company developing off-the-shelf natural killer (NK) cell therapies to treat cancer, today…

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NIH 1999 In Vivo Skin Targeted Gene Therapy By Electroporation

In vivo transfer of genetic information to cells of the skin may offer a useful therapy for skin-specific indications as well as systemic diseases such as hemophilia. The skin presents a large, easily accessible target that contains cells such as keratinocytes that can provide secretory capability to the circulatory system….

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Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms

Knockdown of LFPRLR reduces splenic B-cell subsets in SLE-prone mice To investigate whether the PRL-LFPRLR axis raises the risk of initiation of B-cell malignancies, we compared SLE-prone MRL-lpr mice treated with either control SMO or LFPRLR SMO. Among SLE-prone models, we chose MRL-lpr mice because they accumulate genetic lesions indicative…

Continue Reading Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms

RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

RAGA regulates lung adenocarcinoma progression and macrophage phagocytosis We performed experiments to explore the role of RAGA in lung adenocarcinoma by in vitro cell culture and in vivo xenograft system. To this end, we generated RAGA knockdown A549 and H1299 cancer cells. In vitro cell proliferation assays showed that RAGA…

Continue Reading RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs

Summary of a Single-cell Guided Pipeline to Aid Repurposing of Drugs Using scRNA-seq data, ASGARD repurposes drugs for disease by fully accounting for the cellular heterogeneity of patients (Fig. 1, Formula 1 in “Methods” section). In ASGARD, every cell cluster in the diseased sample is paired to that in the normal…

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circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma

Abstract Circular RNAs have been reported to be widely involved in cancer cell tumorigenesis and drug resistance; here, the aim of this study was to investigate whether circRNA Integrin Subunit Alpha 7 (ITGA7) (circ_ITGA7) was associated with the tumor growth and radiosensitivity of colorectal cancer (CRC). We found that circ_ITGA7…

Continue Reading circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

Lai, L. et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295, 1089–1092. doi.org/10.1126/science.1068228 (2002). ADS  CAS  Article  PubMed  Google Scholar  Kuwaki, K. et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. 11, 29–31. doi.org/10.1038/nm1171 (2005). CAS  Article  PubMed  Google…

Continue Reading A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

Oncolytic Adenovirus with SPAG9 shRNA Driven by DD3 Promoter Improved the Efficacy of Docetaxil for Prostate Cancer

. 2022 Apr 30;2022:7918067. doi: 10.1155/2022/7918067. eCollection 2022. Affiliations Expand Affiliations 1 Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China. 2 Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China. Free PMC article Item in Clipboard Meng…

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N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance | Military Medical Research

Bioinformatics analyses revealed the involvement of m6A modification in cervical cancer progression To better understand whether and how m6A regulators contribute to cervical cancer progression, we first identified 9 m6A writers (WTAP, ZC3H13, METTL3, METTL14, METTL16, VIRMA, RBM15B, RBM15, and CBLL1), 15 m6A readers (FMR1, hnRNPA2B1, hnRNPC, YTHDF1/2/3, YTHDC1/2, LRPPRC,…

Continue Reading N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance | Military Medical Research

Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming

Background: Thymidine kinase 1 (TK1) is a cell cycle-dependent kinase that catalyzes the addition of a gamma-phosphate group to thymidine. The protumorigenic role of TK1 has been reported in various malignancies. However, the role of TK1 in skin cutaneous melanoma (SKCM) remains unclear. This study aimed to explore the molecular…

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RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Significance Hairpin pyrrole-imidazole (Py-Im) polyamides can be programmed to bind a broad repertoire of DNA sequences. Py-Im small molecules can be used to target cancer-specific coding regions and block transcription elongation. This transcription blockage by Py-Im cannot be rescued by transcription elongation factors, such as TFIIS. The mechanism by which…

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Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer b

Introduction Prostate cancer (PCa) is one of the most common genitourinary system malignant tumor in men worldwide. In Asian countries, many patients with PCa are often diagnosed at an advanced stage maybe mostly because of a large population base with relatively backward economic development and imperfect cancer screening system of…

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3 Questions on… Picking the Right Tumor Cell Models for Research

Technologies that have enabled this include tumoroids, and genome engineering techniques, such as CRISPR/Cas9. Patient-derived xenografts … Source link

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