Tag: xGEN

Case Study Reveals Novel Intragenic Deletion of the FXN Gene in Friedreich Ataxia

Ariadna Padró-Miquel, PhD In a recently published case report study of a 32-year-old man with typical clinical features of Friedreich ataxia (FA), parental sample testing led to the identification of a novel intragenic deletion. Overall, the report raises awareness about the potentially higher prevalence of intragenic deletions and highlights the…

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Key gene linked to male bias in autism, Tourette’s, and ADHD uncovered

Research has documented a strong male sex bias in attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and Tourette syndrome (TS). Among males, the hemizygous nature of chromosome X (Chr X) has been a known vulnerability factor. Still, the characterization of rare genetic variation in Chr X has not…

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IDT’s xGen cfDNA Archives – GEN

IDT’s xGen cfDNA Archives – GEN – Genetic Engineering and Biotechnology News genprowebdirectory Recently Featured Read the Digital Edition Scroll…

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Enduring Basics and Evolving Enzyme Kits

By MaryAnn Labant Next-generation sequencing (NGS) is increasingly employed to dive deeper into complex biological mechanisms in a myriad of disciplines. But as with most methodologies, the quality of the input material determines the quality of the resultant data. High-quality sample preparation is the foundation of NGS, and the choices…

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Scientists take next big step in understanding genetics of schizophrenia

Graphical Abstract. Credit: Cell Genomics (2023). DOI: 10.1016/j.xgen.2023.100404 Genetically speaking, we are individuals different from each other because of slight variations in our DNA sequences—so-called genetic variants—some of which have dramatic effects we can see and comprehend, from the color of our eyes to our risk for developing schizophrenia—a debilitating…

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Reanalysis of Iceman’s genome reveals dark skin, baldness and Anatolian ancestry

Since 2012, which is when Ötzi’s genome was sequenced for the first time, DNA sequencing technologies have advanced enormously. This new study reveals that compared to other contemporary Europeans, Ötzi’s genome had an unusually high proportion of genes in common with those of early farmers from Anatolia, that his skin…

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Salesforce Takes a Giant Leap with Generative AI

When it comes to companies heavily investing in the capabilities and advantages of generative AI, Salesforce undoubtedly takes the lead. Marc Benioff, co-founder and CEO of Salesforce even said that generative AI could possibly be the most important technology of any lifetime. In March, the San Francisco-based CRM leader became…

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New Products Posted to GenomeWeb: Qiagen, Integrated DNA Technologies, Revvity, More

Qiagen CGT Viral Vector Lysis Kit, Customized Biopharma dPCR Assay Design Service Qiagen has launched a new digital PCR kit and a service to support customers developing cell and gene therapy (CGT) applications. The CGT Viral Vector Lysis Kit enables a standardized workflow from cell lysates to perform absolute and precise quantification…

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SickKids scientists shine light on the complex genetics that underlie blood pressure regulation

Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide. While the human genome comprises coding and non-coding…

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Siblings with autism share more of dad’s genome, not mom’s

For decades, Cold Spring Harbor Laboratory scientists and collaborators have invested millions of dollars into deciphering the genetic causes of autism spectrum disorder (ASD). Their efforts have produced useful insights for diagnosticians, therapists, and educators, helping to change the way people think about this common neurodevelopmental disorder. Now, they’ve taken…

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Researchers develop a new powerful resource to study extracellular RNA

An international team led by researchers at Baylor College of Medicine with the National Institutes of Health Extracellular RNA Communication Consortium and the Bogdan Mateescu laboratory at the ETH Zürich and University of Zürich has developed a new powerful resource to study extracellular RNA (exRNA), a novel form of cell-to-cell…

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A New, Broader Genomic View

Instead of just piecing together short bits of a genome through short-read genomic sequencing, EMBL researchers used long-read nanopore sequencing to gain a more comprehensive understanding of DNA mutation connected to a cancer genome. Credit: Joana Gomes Campos de Carvalho/EMBL Researchers seeking to gain deeper insights into the relationship between…

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Powering Toxicogenomic Studies by Applying Machine Learning to Genomic Sequencing and Variant Detection

Alexandrov LB, Nik-Zainal S, Wedge DC et al (2013) Signatures of mutational processes in human cancer. Nature 500:415–421. doi.org/10.1038/nature12477 CrossRef  CAS  Google Scholar  Alioto TS, Buchhalter I, Derdak S et al (2015) A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun 6:10001. doi.org/10.1038/ncomms10001 CrossRef  CAS …

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Ultima Genomics and Integrated DNA Technologies to Enable Application Portfolio on Ultima Sequencing Platforms

NEWARK, Calif., Feb. 6, 2023 /PRNewswire/ — Ultima Genomics, Inc., a developer of a revolutionary new ultra-high throughput sequencing architecture, today announced a strategic collaboration with global genomics solutions provider Integrated DNA Technologies (IDT) to enable key next generation sequencing (NGS) applications on Ultima platforms. Together, the companies plan to…

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Integrated DNA Technologies Expands Access, Expedites Turnaround Time, for Minimal Residual Disease (MRD) Solutions for Cancer Research

CORALVILLE, Iowa–(BUSINESS WIRE)–To help researchers accurately measure circulating tumor DNA (ctDNA) from the most degraded and low-input samples, Integrated DNA Technologies today launched a complete MRD workflow for tumor-informed approaches. The launch expands access to IDT’s xGen MRD Hybridization Panel and xGen cfDNA & FFPE DNA Library Preparation Kit, which…

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